Integrating single-cell transcriptomics and machine learning reveals 4-aminobiphenyl exposure signatures and novel diagnostic biomarkers in bladder cancer [0.03%]
单细胞转录组学和机器学习的结合揭示联苯胺暴露膀胱癌特征及新型诊断生物标志物
Yangyang Xu,Xiujia Wang,Xinxin Wang et al.
Yangyang Xu et al.
Background: Bladder cancer ranks among the top four most common malignancies in men worldwide. Despite therapeutic advancements, metastatic cases remain associated with dismal survival rates, highlighting the critical imp...
Inflammation related proteins and PLCG1 may contribute to papillary thyroid carcinoma risk through a potential regulatory axis [0.03%]
炎症相关蛋白和PLCG1可能通过潜在的调控轴促进乳头状甲状腺癌发病风险
Shi-Qi Wang,Miao Yang,De-Wei Rao et al.
Shi-Qi Wang et al.
Background: Papillary thyroid carcinoma (PTC) is usually indolent, but a subset of patients shows aggressive behavior. Understanding protein-level mechanisms is essential for identifying new therapeutic targets. ...
Occult breast cancer with CSF TBA positivity and abnormal involuntary movements [0.03%]
occult乳腺癌合并脑脊液TBA阳性及异常不自主运动
Wenyan Zhang,Yajie Liu,Jin Zhen
Wenyan Zhang
Occult breast cancer (OBC) is a rare and special type of breast cancer. The initial symptom is an enlarged axillary lymph node. Paraneoplastic neurological syndromes (PNS) are a group of syndromes that are caused by malignant tumors and dam...
Web-based explainable machine-learning tool for predicting five-year recurrence of colorectal cancer after curative resection: multicentre retrospective cohort study [0.03%]
基于网络的解释型机器学习工具用于预测根治性切除术后五年内结直肠癌复发：多中心回顾性队列研究
Chi-Sheng Chen,Tai-Han Lin,Hsing-Yi Chung et al.
Chi-Sheng Chen et al.
Objective: The World Health Organization identifies colorectal cancer as the third-most diagnosed malignancy and second leading cause of cancer-related mortality worldwide. Up to 30% of patients relapse within 5 years pos...
Collaboration networks and knowledge structure in cancer and cellular senescence research (2000-2025): a bibliometric perspective [0.03%]
基于文献计量的癌症和细胞衰老研究中的合作网络与知识结构（2000-2025）
He Zhu,Shuangjia Pan,Yujia Zhou et al.
He Zhu et al.
Cancer is a leading cause of death worldwide, posing substantial public health challenges. Cellular senescence, a stress-induced cell fate characterized by stable cell-cycle arrest and a hypersecretory state, plays dual roles in tissue repa...
CircPPP1CB subtype, hsa_circ_0007439, promotes nasopharyngeal carcinoma progression by upregulating KRT1 [0.03%]
环状RNA circPPP1CB亚型（hsa_circ_0007439）通过上调角蛋白KRT1促进鼻咽癌进展
Fei Li,Ting Xu,Rui Sun et al.
Fei Li et al.
Background: Nasopharyngeal carcinoma (NPC) is characterized by pronounced metastatic and invasive properties. Emerging research has elucidated that circular RNAs (circRNAs) are intricately associated with the pathogenesis...
Integration of exosome-related genes and differential expression analysis reveals potential biomarkers for prostate cancer [0.03%]
外泌体相关基因集的整合及差异表达分析揭示前列腺癌潜在生物标志物
Shengnan Huang,Chunyan Hu,Zhongqi Guo et al.
Shengnan Huang et al.
Background: Prostate cancer (PCa) is a prevalent malignancy in men, with exosomes playing a key role in tumor microenvironment and disease progression, yet their molecular mechanisms remain unclear.This study aims to iden...
Dual inhibition of ATR and PARP reverses acquired PARP inhibitor resistance in triple negative breast cancer [0.03%]
血管内皮生长因子受体和多聚ADP核糖聚合酶联合抑制逆转三阴性乳腺癌获得性的多聚ADP核糖聚合酶抑制剂耐药性
Gamze Guney Eskiler,Ayten Haciefendi,Kayhan Ozdemir et al.
Gamze Guney Eskiler et al.
Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) have attracted significant attention in triple negative breast cancer (TNBC) treatment. However, the acquired or de novo PARP inhibitor resistance limits treatment success. Ataxia telang...
RANBP1 promotes immune evasion in triple-negative breast cancer by suppressing T cell infiltration via the miR-769-5p/PRUNE2 axis [0.03%]
RANBP1通过miR-769-5P/PRUNE2轴抑制T细胞浸润促进三阴性乳腺癌免疫逃逸
Pengxia Song,Xianglin Liu,Huiping Qiu et al.
Pengxia Song et al.
Background: T cell dysfunction in the tumor microenvironment (TME) is a major obstacle to effective immunotherapy in triple-negative breast cancer (TNBC). The molecular mechanisms underlying T cell exclusion remain poorly...
Conditional survival prediction in elderly patients with hormone receptor positive locally advanced breast cancer using a competing risks model [0.03%]
竞争风险模型在激素受体阳性局部晚期乳腺癌老年患者中预后预测的作用
Jun Zhang,Yunyun Zhao,Wenhui Wang
Jun Zhang
Purpose: Conditional survival (CS) analysis reveals dynamic changes in long-term survival, offering cancer survivors more accurate prognosis. We aimed to develop a prognostic model for elderly patients with hormone recept...