Regulatory roles of LncRNAs in colorectal cancer immune evasion: current concepts and future perspectives [0.03%]
长链非编码RNA在结直肠癌免疫逃逸中的调控作用：当前概念及未来展望
YuHan Wang,YiShan Li,Peng Huang et al.
YuHan Wang et al.
Colorectal cancer (CRC) remains a major global health challenge, ranking as the second leading cause of cancer-related mortality due to late-stage diagnosis and limited effective treatments. Long non-coding RNAs (lncRNAs) have emerged as cr...
Quercetin suppresses endometrial cancer stem cells via ERα-mediated inhibition of STAT3 signaling [0.03%]
槲皮素通过雌激素受体介导的信号转导及转录激活蛋白3信号通路抑制作用抑制子宫内膜癌干细胞
Ou Tang,Ling Yang,Zhenyu Cheng et al.
Ou Tang et al.
Background: Quercetin, a secondary metabolite derived from plants with both medicinal and edible values, has demonstrated potential in cancer treatment, including endometrial carcinoma. However, its anti-tumor effect on c...
Mechanisms of synergistic regulation of the tumor microenvironment by fibroblasts and keratinocytes in esophageal squamous cell carcinoma [0.03%]
食管鳞状细胞癌中成纤维细胞和角质形成细胞协同调节肿瘤微环境的机制研究
Yujie Weng,Rong Jia,Pengfei Ning
Yujie Weng
Background: Esophageal squamous cell carcinoma (ESCC) is a highly invasive malignant tumor, and its tumor microenvironment (TME) plays a pivotal role in disease progression and treatment resistance. As key components of t...
Causal association between rheumatoid arthritis and pancreatic cancer: a bidirectional two-sample Mendelian randomization study [0.03%]
双向两样本孟德尔随机化研究类风湿关节炎与胰腺癌的因果关系
Jujie Li,Hao Hua,Luyao Fu
Jujie Li
Objective: Elucidating the causal relationship between rheumatoid arthritis (RA) and pancreatic cancer (PC) remains methodologically challenging due to limitations inherent in observational studies. This study applied a b...
Association between weight loss and survival outcomes in patients with colorectal cancer: a meta-analysis [0.03%]
体重减轻与结直肠癌患者生存结果之间的关系：一项荟萃分析
Guofang Wang,Ziyan Liu,Dandan Gong et al.
Guofang Wang et al.
Background: Weight reduction is a common clinical feature observed in patients with colorectal cancer and often reflects underlying tumor burden or nutritional status. This meta-analysis aims to systematically synthesize ...
The role of liquid biopsy in the management of concurrent Hodgkin lymphoma and ovarian carcinoma treated with nivolumab [0.03%]
nivolumab治疗伴发霍奇金淋巴瘤和卵巢癌的管理中液体活检的作用
Veronika Hanáčková,Jan Grohmann,Helena Urbánková et al.
Veronika Hanáčková et al.
The simultaneous occurrence of Hodgkin lymphoma (HL) and ovarian carcinoma (OC) is rare and presents unique challenges in diagnosis and treatment. Circulating tumour DNA (ctDNA) offers a minimally invasive method for detecting minimal resid...
Integrative SMR and single cell & spatial analysis reveals the spatial heterogeneity and prognostic value of CASP9-mediated apoptotic pathways in clear cell renal cell carcinoma [0.03%]
整合SMR和单细胞及空间分析揭示CASP9介导的凋亡通路在透明细胞肾细胞癌中的空间异质性和预后价值
Zijie Yu,Xinghan Yan,Wenchuan Shao et al.
Zijie Yu et al.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer and remains a clinical challenge due to its frequent resistance to therapy and poor prognosis in advanced stages....
Multi-omics study of prognostic models and molecular networks related to ovarian cancer [0.03%]
与卵巢癌相关的预后模型和分子网络的多组学研究
Piaopiao Bian,Shaoyan Liu,Wei Zhang et al.
Piaopiao Bian et al.
Objective: Ovarian cancer (OV) is considered the most lethal gynecological cancer in women. Despite significant advancements in treatment and risk-stratification methods, these approaches remain far from ideal. This study...
Inflammation-driven prognostic model and immune landscape profiling in osteosarcoma [0.03%]
骨肉瘤的炎症驱动型预后模型及免疫图谱分析
Rongquan Zhang,Xueliang Zhou,Chenxiao Shen
Rongquan Zhang
Background: Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults, and its prognosis remains poor, particularly in metastatic cases. Chronic inflammation within the tumor microenviro...
Efficacy and safety of anlotinib maintenance therapy in limited-stage small cell lung cancer [0.03%]
安罗替尼治疗局限期小细胞肺癌的有效性和安全性
Sha Li,Zhonghua Chen,Jie Lv et al.
Sha Li et al.
Background: Effective maintenance therapy options after first-line chemoradiotherapy for limited-stage small cell lung cancer (LS-SCLC) remain limited. Anlotinib, a multi-target tyrosine kinase inhibitor, was evaluated fo...