Artificial intelligence and multi-omics revealed the authentic regulation of ADP-ribosylation in modulation Treg/Th17 ecosystem and multi-target therapeutic strategy enrichment for HBV+ Hepatocellular Carcinoma patients [0.03%]
人工智能和多组学揭示了ADP-核糖基化在调节HBV+肝细胞癌患者Treg/Th17生态系统中的真正作用及丰富多重靶点的治疗策略
Zijing Lin
Zijing Lin
Objective: Dysregulation of Protein post-translation(PTM) and Treg/Th17 balance contribute to the progression of Hepatocellular Carcinoma(HCC) patients. Our study aims to investigate the ADP-ribosylation mechanisms in reg...
Multi-cohort integration and machine learning identify CPVL as a novel oncogenic driver in gastric cancer [0.03%]
多队列整合和机器学习识别出CPVL是胃癌中的一个新的致癌驱动基因
Xin Li,Jiahan Chen,Hongpen Tian et al.
Xin Li et al.
Background: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, and the prognosis of advanced GC remains poor. Systematic identification of robust biomarkers through multi-cohort integration...
Circ_0001313 promotes an immunosuppressive tumor microenvironment through GM-CSF-associated granulocytic myeloid cell activation in colorectal cancer [0.03%]
circ_0001313通过GM-CSF相关的粒细胞髓样细胞活化促进结直肠癌免疫抑制性肿瘤微环境形成
Ya Liu,Longfei Liu,Yingping Quan et al.
Ya Liu et al.
Background: Circ_0001313 is upregulated in colorectal cancer (CRC) and has been implicated in tumor progression, but its role in remodeling the immune microenvironment remains incompletely defined. This study investigated...
Pan-cancer prioritization of CCDC69 reveals an immune-enriched and therapeutically sensitive breast cancer phenotype [0.03%]
泛癌优先考虑CCDC69揭示了免疫丰富且易于治疗的乳腺癌表型
Yi Chen,Boyang Li,Jinghao Pan et al.
Yi Chen et al.
Background: Coiled-coil domain-containing protein 69 (CCDC69) has been implicated in tumor biology, but its pan-cancer immunogenomic context and relevance to breast cancer remain insufficiently defined. ...
Single-cell reanalysis highlights the MIF-PTGDR axis as a candidate immunoregulatory program in hepatocellular carcinoma [0.03%]
单细胞重新分析揭示MIF-PTGDR轴是肝细胞癌候选免疫调节程序
Dingzhi Liu,Lang Yan,Huiya Chen et al.
Dingzhi Liu et al.
Background: Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies worldwide, and immune evasion is a major determinant of tumor progression and therapeutic resistance. The tumor microenvironment (TME)...
Integrated single-cell RNA sequencing and mendelian randomization reveals the role of resting regulatory T cells in skin melanoma prognosis [0.03%]
整合单细胞RNA测序和孟德尔随机化揭示休止调节性T细胞在皮肤黑色素瘤预后中的作用
Yadong Wang,Ti Guo,Caidie Zhang et al.
Yadong Wang et al.
Background: Cutaneous melanoma (SKCM) is an aggressive malignancy with poor prognosis. Recent studies have shown that immune cells in the tumor microenvironment, particularly resting regulatory T cells (Resting Treg), pla...
Preoperative systemic inflammatory markers (SII, PLR, MRR) as potential indicators of axillary lymph node metastasis in early-stage breast cancer [0.03%]
术前系统性炎性标志物（SII、PLR、MRR）作为早期乳腺癌腋窝淋巴结转移潜在指示器的效果研究
Haofeng Wang,Beimin Gao,Haiyan Zhao et al.
Haofeng Wang et al.
Background: Axillary lymph node metastasis (ALNM) in a pivotal prognostic indicator in breast cancer. Systemic Immune-Inflammation Index (SII), Platelet-to-Lymphocyte Ratio (PLR), and Monocyte-to-Red blood cell Ratio (MRR...
Xuezhong Zhang,Wen Xu,Xiaolei Wang et al.
Xuezhong Zhang et al.
Background: MEX3D, a member of the MEX3 RNA-binding protein family, has emerged as a potential regulatory molecule in cancer. However, its role across different tumor types remains largely unexplored. ...
Metabolic reprogramming regulates macrophage polarization to impact ovarian cancer progression [0.03%]
代谢重组调控巨噬细胞极化影响卵巢癌进展
Meng Zhang,Haizhou Fang,Shuangshuang Yang et al.
Meng Zhang et al.
Metabolic reprogramming and macrophage polarization exhibit a tightly regulated reciprocal interplay, wherein the modulation of energy metabolic pathways and signaling networks directly dictates the functional phenotype and immune responses...
Elucidating the pathway activity and prognostic significance of diverse regulatory cell death patterns in pancreatic ductal adenocarcinoma [0.03%]
阐明胰腺导管腺癌中各种调控性细胞死亡模式的途径活性和预后意义
Lingling Jin,Yanwen Chen,Jiazheng Sun et al.
Lingling Jin et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a five-year survival rate below 10%. Regulatory cell death (RCD) plays a critical role in tumor progression and therapy response, yet its prognostic implications...