Xinlong Huang,Yafei Huang,Xiangcong Wei et al.
Xinlong Huang et al.
Exosomes are nanoscale extracellular vesicles secreted by cells via endosomal pathways. They mediate intercellular communication by transporting bioactive molecules, including proteins, lipids, and nucleic acids. During tumorigenesis, exoso...
Predicting of survival in metastatic melanoma patients under anti-PD-1 monotherapy using genomic mutation and copy number variation [0.03%]
基于基因组突变和拷贝数变异的转移性黑色素瘤患者抗PD-1单药治疗生存预测研究
Yu Wang,Wei Tang,Yuanyuan Wang et al.
Yu Wang et al.
Background: Although PD-1 inhibitors have significantly reduced metastatic melanoma patients' mortality, only a small proportion of these patients actually benefit. We aim to develop some parsimonious predictive models fo...
Peptides as integrative modulators for clinical prognosis and targeted therapy in pancreatic cancer [0.03%]
肽作为整合调节物在胰腺癌临床预后和靶向治疗中的作用
Bhawana Yadav,Shiva Prasad Kollur,Amena Ali et al.
Bhawana Yadav et al.
Pancreatic cancer remains a formidable global health challenge, ranking as the twelfth most common malignancy yet claiming an outsized toll with dismal 5-year survival rates 13.3%, largely due to late-stage diagnosis and limited therapeutic...
Oncogenic signaling pathways in ameloblastoma and their implications for precision based therapy [0.03%]
成釉细胞瘤的致癌信号通路及其对精准治疗的意义
S Boukssim,H Soualem,L Benjelloun
S Boukssim
Ameloblastoma is an odontogenic epithelial tumor characterized by a paradoxical clinical behavior. Although histologically benign and typically non-metastatic, it demonstrates aggressive local growth, extensive bone destruction, and a high ...
Disrupting the CBFβ-SMMHC-RUNX1 oncogenic protein-protein interaction in inv(16) AML: from fusion biology to targeted therapy [0.03%]
从融合生物学出发靶向治疗inv（16）急性髓系白血病中的CBFβ-SMMHC-RUNX1致癌蛋白-蛋白相互作用
Emadeldin M Kamel,Sally Mostafa Khadrawy,Mohamed A M Ali et al.
Emadeldin M Kamel et al.
Core-binding factor (CBF) leukemias, including inv(16) AML, involve RUNX1/CBFβ chromosomal rearrangements that generate oncogenic fusion proteins. In inv(16) AML, the CBFβ-SMMHC fusion (CBFB-MYH11) dominantly perturbs RUNX1 by sequesterin...
Association of CA12 with calcification in ER+/HER-2 negative breast cancer [0.03%]
CA12与ER+/HER-2阴性乳腺癌钙化的关联研究
Yuxuan Zhu,Qin Du,Yiyang Ma et al.
Yuxuan Zhu et al.
Background: Calcification in breast cancer is closely associated with ER+/HER2- breast cancer, and identifying key molecular markers is crucial for early diagnosis and treatment. ...
A multicenter study identifies an immune inflammatory and nutritional prognostic signature in intrahepatic cholangiocarcinoma [0.03%]
一项多中心研究在肝内胆管癌中鉴定出一种免疫炎症和营养预后特征
Jie Tang,Benjie Xu,Yun Tao et al.
Jie Tang et al.
Background: Immune dysfunction, systemic inflammation, and malnutrition are closely associated with tumor progression and prognosis in intrahepatic cholangiocarcinoma (ICC). This multicenter retrospective study aimed to e...
Integrated single-cell and bulk transcriptomic analyses unveil a necroptosis-related prognostic model and its association with tumor microenvironment remodeling in gastric cancer [0.03%]
整合单细胞和批量转录组分析揭示了胃癌中与坏死相关预后模型及其对肿瘤微环境重塑的关联
Yuanshuai Li,Wenting Pan,Xiaomin Ying et al.
Yuanshuai Li et al.
Background: Necroptosis has emerged as a critical regulator in tumor progression and therapeutic response, yet its prognostic significance and influence on the tumor microenvironment (TME) in gastric cancer (GC) remain po...
Stereotactic body radiotherapy and other locoregional therapies for hepatocellular carcinoma in patients with cirrhosis: real-world treatment allocation, BCLC-stratified outcomes, and prognostic determinants [0.03%]
立体定向身体放射治疗和其他局部区域性疗法在肝硬化患者的肝细胞癌治疗中的应用：实际分配、BCLC分层结果和预后决定因素
Cyriac Abby Philips,Tharun Tom Oommen,Jose Paul et al.
Cyriac Abby Philips et al.
Background and aims: Stereotactic body radiotherapy (SBRT) has emerged as a treatment option for hepatocellular carcinoma (HCC) in patients ineligible for thermal ablation or surgery. However, real-world evidence on how p...
Association between ranitidine use and thyroid cancer based on FAERS and VigiAccess databases [0.03%]
基于FAERS和VigiAccess数据库的雷尼替丁用药与甲状腺癌关联分析
Qingli Shen,Zhonghua Fu,Zhengchao Xia et al.
Qingli Shen et al.
Purpose: The potential carcinogenic risk of ranitidine has sparked widespread controversy, and its relationship with thyroid cancer remains unclear. This study aimed to evaluate the disproportionality signal for thyroid c...