Non-WNT/non-SHH medulloblastoma in siblings: case report and literature review [0.03%]
非WNT/非SHH型髓母细胞瘤家族病例报告及文献复习
Meng Huang,Jian Li,Bo Liu et al.
Meng Huang et al.
Purpose: Medulloblastoma (MB), a malignant cerebellar embryonal tumor, is predominantly sporadic, with rare familial cases linked to germline mutations in SUFU, PTCH1, TP53, and APC, primarily driving WNT and SHH molecula...
Identification of candidate susceptibility genes for cutaneous malignant melanoma through integrated multi-method analysis [0.03%]
通过多方法综合分析鉴定皮肤恶性黑色素瘤易感基因候选基因
Ping Zhou,Xin Jiang,Wanchun Wang et al.
Ping Zhou et al.
Background: Cutaneous malignant melanoma (CMM) is a deadly skin cancer with genetic basis. Although genome-wide association studies (GWAS) have identified various risk loci, their functional consequences remain largely un...
Decreased IL20RA expression serves as a predictor of unfavorable prognosis in endometrial cancer [0.03%]
IL20RA表达降低可作为子宫内膜癌不良预后的预测指标
Yue-Feng Liu,Dan Li,Ke Shi et al.
Yue-Feng Liu et al.
Objective: Overexpression of interleukin-20 receptor A (IL20RA) has been implicated in promoting tumor growth, metastasis, and unfavorable prognosis of various malignancies. However, its role in endometrial cancer (EC) re...
Prognostic value of anoikis- and epithelial-mesenchymal transition-related genes and development of a prognostic risk model in thyroid cancer [0.03%]
用于甲状腺癌预后预测的悬浮应激和上皮间质转化相关基因的预后价值及预后风险模型的建立
Kai-Fang Xiang,Ling Wang,Yan Wu et al.
Kai-Fang Xiang et al.
Hsa_circ_0062522 affects the progression and tamoxifen resistance of estrogen receptor-positive breast cancer by targeting miR-3163 [0.03%]
Hsa_circ_0062522通过靶向miR-3163影响雌激素受体阳性乳腺癌的进展和托瑞米芬耐药性
Yan Bian,Yanjun Ma,Yinxiang Xu et al.
Yan Bian et al.
Background: Multiple circRNAs are abnormally expressed in breast cancer (BC), which may be involved in tumor progression and promote anti-tumor drug resistance. ...
Association of LAMA3 expression with perineural invasion and chemoresistance in pancreatic ductal adenocarcinoma [0.03%]
LAMA3表达与胰腺导管腺癌的神经周围浸润及化疗耐药之间的关系
Yang Yang,Yongqiang Chen,Xiaohong Wang et al.
Yang Yang et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a common type of malignant tumor of the pancreas with high aggressiveness and low prognosis. Due to the insidious early symptoms of pancreatic adenocarcinoma, patient...
Genetic evidence for causal association between platelet count and glioma risk through Mendelian randomization analysis [0.03%]
孟德尔随机化分析提供的血小板计数与胶质瘤风险因果关联的遗传证据
XiaoYong Han,Mengyan Chen,Zhisheng Ji et al.
XiaoYong Han et al.
Background: Glioma is the most common primary brain tumor in adults, with glioblastoma (GBM) being the most aggressive subtype. The causal relationship between platelet count and glioma risk remains unclear. This study ai...
Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study [0.03%]
基于孟德尔随机化研究探索脑脊液中338种代谢物在原发性脑恶性肿瘤发病风险中的作用
Hengqiu He,Rongxin Liao,Xue Wu et al.
Hengqiu He et al.
Introduction: Cerebrospinal fluid (CSF) metabolites are implicated in various neurological disorders, but their relationship with primary brain malignancies remains unclear. This study aims to use a two-sample Mendelian r...
Multi-omics analysis reveals PIAS family gene dysregulation as a driver of head and neck squamous cell carcinoma (HNSC) progression and therapeutic vulnerability [0.03%]
多组学分析揭示PIAS家族基因失调作为头颈鳞状细胞癌(HNSC)进展和治疗弱点的驱动因素
Mumtaz Hussain,Mehreen Ishfaq,Syeda Amber Hameed et al.
Mumtaz Hussain et al.
Background: Head and neck squamous cell carcinoma (HNSC) stand as one of the most fatal malignancies worldwide. The intricate nature of this disease has contributed to a limited understanding of its diagnostic and prognos...
Potential function of miRNA as a diagnostic biomarker for human ovarian cancer [0.03%]
微小核糖核酸作为卵巢癌诊断生物标志物的潜能
Furong Liu,Zihao An,Chao Tang et al.
Furong Liu et al.
Ovarian cancer (OC), a common gynecological malignancy, seriously threatens the lives and health of women. Though several serological markers are used for the early diagnosis of OC, most have low specificity and sensitivity. Micro-RNAs (miR...