Constructing and investigating a disulfidptosis-associated LncRNA signature for prognostic prediction in gastric cancer [0.03%]
构建和研究胃癌中与半胱氨酸蛋白酶激活的细胞凋亡相关的长链非编码RNA特征用于预后预测
Namei Li,Zhongyi Tong,Xiaoling She
Namei Li
Background: Gastric cancer (GC) prognosis remains poor, necessitating reliable biomarkers. Disulfidptosis represents a promising therapeutic frontier. This study aimed to construct a prognostic model based on disulfidptos...
Immune microenvironment and its influence on CAR-T treatment outcomes in B-NHL [0.03%]
免疫微环境及其对B细胞非霍奇金淋巴瘤CAR-T治疗效果的影响
Danyang Li,Zhonghua Fu,Rui Liu et al.
Danyang Li et al.
B-cell non-Hodgkin's lymphoma (B-NHL) is a highly heterogeneous tumor. Currently, CAR-T cells have been widely used in the treatment of B-cell lymphomas, with a complete response rate reaching 40%-60%. More and more studies have shown that ...
Interpretable machine learning models for bladder cancer overall survival prediction development and external validation via SEER database and Chinese cohort analysis [0.03%]
基于SEER数据库和中国人群数据的膀胱癌总生存预测模型的构建及外部验证研究
Saimaitikari Abudoubari,Abudouresuli Tuersun,Sailidan Mutailipu et al.
Saimaitikari Abudoubari et al.
Objective: We developed interpretable machine learning(ML) models to predict overall survival in bladder cancer patients. This approach aims to improve the interpretability and transparency of our modeling results. ...
ELK3 promotes cisplatin resistance in ovarian cancer via regulating CHD4 gene expression [0.03%]
ELK3通过调节CHD4基因表达促进卵巢癌耐药性
Qihua Peng,Kaho Leung,Yixuan Sun et al.
Qihua Peng et al.
Background: Cisplatin resistance remains a major obstacle in the treatment of ovarian cancer (OC). Although ELK3, an ETS transcription factor, has been implicated in chemoresistance across various cancers, its specific ro...
PRAS40 enhances glycolysis by facilitating G6PI/PGK1/LDHA complex assembly in colorectal cancer [0.03%]
PRAS40通过促进G6PI/PGK1/LDHA复合体组装增强结直肠癌糖酵解作用
Tianhua Zhang,Chengfei Zhang,Yukun Hao et al.
Tianhua Zhang et al.
Colorectal cancer (CRC) is the third most common malignant tumor worldwide, while its underlying pathogenic mechanisms remain inadequately understood. Glycolysis reprogramming represents a key metabolic hallmark of CRC, the mechanism of whi...
Disappearance of histone H3F3A mutation in metastatic giant cell tumor of bone during long term follow up [0.03%]
长期随访过程中骨巨细胞瘤转移灶中出现H3F3A基因突变缺失
Takashi Ariizumi,Naoki Oike,Yudai Murayama et al.
Takashi Ariizumi et al.
Background: Giant cell tumor of bone (GCTB) is a locally aggressive tumor that rarely metastasizes, although a small subset undergoes malignant transformation. H3F3A driver mutations have been recognized as characteristic...
The pyroptosis and inflammatory response-related long noncoding RNA signature as a novel prognostic biomarker of head and neck squamous cell carcinoma [0.03%]
头颈鳞状细胞癌的焦亡和炎性反应相关长链非编码RNA标志物作为新型预后生物标志物
Xian Xu,Qian Liu,Siyuan Liu et al.
Xian Xu et al.
Background: Head and neck squamous cell carcinoma (HNSCC) represents a significant malignancy arising from mucosal epithelia. Pyroptosis, a gasdermin-mediated programmed necrotic cell death mechanism, has emerged as a cri...
DLX6-AS1 promotes the progression of Wilms tumor by sponging miR-195-5p to upregulate KIF23 in Wilms tumor cells [0.03%]
DLX6-AS1通过海绵吸附miR-155-5p来上调KIF23从而促进wilms肿瘤的进展
Jiawei Chen,Guowei Li,Luqiu Chen et al.
Jiawei Chen et al.
Background: Wilms tumor (WT) is a frequently diagnosed cancer in pediatric patients. DLX6-AS1 contributes to the emergence of several cancers. Nonetheless, the role of DLX6-AS1 in WT remains unclear. This study aimed to e...
Metabolomic profiling of exhaled breath condensate identifies a novel biomarker panel for detecting thyroid and breast cancer [0.03%]
呼出气冷凝物代谢组学鉴定出一组新型生物标志物用于检测甲状腺癌和乳腺癌
Fangning Gao,Yawen Yu,Mao Sun et al.
Fangning Gao et al.
Background: The non-invasive detection of cancer via exhaled breath condensate (EBC) represents a promising frontier in oncology. This study explores the metabolic profiles of EBC to identify biomarkers for the early dete...
RBM43 promotes glioma aggressiveness and shapes the immune microenvironment through macrophage polarization [0.03%]
RBM43通过巨噬细胞极化促进胶质瘤的侵袭性并重塑免疫微环境
ZiLong Tan,DaPeng Wang,XiaoLong Tang et al.
ZiLong Tan et al.
Objective: To investigate the expression pattern of RBM43 in glioma and evaluate its prognostic significance, with particular attention to its association with the glioma immune microenvironment. ...