Role of non-coding RNAs in radiotherapy sensitivity in non-small cell lung cancer [0.03%]
非编码RNA在非小细胞肺癌放射敏感性中的作用
Peipei Yang,Rui Chen,Huijuan He
Peipei Yang
Lung cancer (LC) is consistently the leading cause of cancer-related deaths worldwide. Radiotherapy is a crucial means of treating LC, and about 60-70% of LC patients require radiotherapy. However, radiotherapy resistance remains a signific...
Development and explanation of a machine learning model for identifying non-localized early-onset T1 colorectal cancer [0.03%]
一种识别非局部早期发病T1结直肠癌的机器学习模型的研发与解释
Yin Zhang,Fuzhou Han,Mingyu Zheng et al.
Yin Zhang et al.
Background: For patients with early-onset T1 colorectal cancer (CRC), it is crucial to perform radical resection with minimal tissue damage. This study aims to develop and elucidate a machine learning model for the identi...
SLIT2 inhibits lung adenocarcinoma progression by suppressing epithelial-mesenchymal transition [0.03%]
SLIT2通过抑制上皮间质转化来抑制肺腺癌进展
Zhimeng Chen,Hu Chen,Yuan Cui et al.
Zhimeng Chen et al.
Lung adenocarcinoma (LUAD), the most common subtype of lung cancer, is a major contributor to worldwide cancer deaths. Although the slit guidance ligand (SLIT) protein family is implicated in both normal biological processes and disease sta...
Multi-omics analysis reveals different cholesterol metabolism subtypes in colorectal cancer [0.03%]
多组学分析揭示结直肠癌中不同的胆固醇代谢亚型
Yu Sun,Deyang Kong,Huiru Zhang et al.
Yu Sun et al.
Background: Cholesterol metabolism (CM) plays a critical role in the progression of colorectal cancer (CRC), yet its molecular and immunological implications remain incompletely understood. Therefore, we aimed to identify...
Machine learning multiomics Deciphers GRHL2 associated tumor microenvironment evolution guiding precision therapeutics in breast cancer [0.03%]
机器学习多组学解析乳腺癌中GRHL2相关肿瘤微环境演进指导精准治疗
Jingjing Zhao,Zhengkuo Wei,Jun Tang et al.
Jingjing Zhao et al.
Grainyhead-like 2 (GRHL2) has been implicated in various cancers, but its role in breast cancer (BRCA) remains poorly understood. This study aims to comprehensively characterize the prognostic and immunological significance of GRHL2 in BRCA...
Single-cell transcriptomic analysis reveals the heterogeneity and functional characteristics of macrophage subpopulations in colon cancer [0.03%]
单细胞转录组分析揭示结直肠癌巨噬细胞亚群的异质性和功能特征
Jiazheng Zhao,Baochun Wang,Xiao Li et al.
Jiazheng Zhao et al.
Background: Colon cancer remains one of the leading causes of cancer-related mortality globally. Tumor-associated macrophages (TAMs) are key contributors to tumor progression within the tumor microenvironment (TME). Howev...
Exploring targeted therapies against RFPL3 for non-small cell lung cancer with lymph node metastasis [0.03%]
针对伴淋巴结转移的非小细胞肺癌的RFPL3靶向治疗研究
Chuan Lin,Yi Jiang,Fei Xu
Chuan Lin
Background: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide, marked by its aggressive nature and high likelihood of metastasis. The precise function of ret finger protein...
Integrated multi-omics analysis identifies key biomarkers associated with post-translational modifications and RNA methylation in clear cell renal cell carcinoma [0.03%]
整合多组学分析识别出与透明细胞肾细胞癌中翻译后修饰和RNA甲基化相关的关键生物标志物
Taisen Pang,Yongzhi He,Jie Liao et al.
Taisen Pang et al.
Background: This study aimed to identify clinically relevant molecular signatures and biomarkers associated with post-translational modifications (PTMs) and RNA methylation in clear cell renal cell carcinoma (ccRCC) by in...
Prediction of prognostic biomarkers for hepatocellular carcinoma and immune microenvironment infiltration based on single-cell sequencing and RNA-Seq integration [0.03%]
基于单细胞测序和RNA-seq数据集成的肝癌预后生物标志物及其免疫微环境浸润预测研究
Yiyan Zhai,Xuan Fan,Peiying Lu et al.
Yiyan Zhai et al.
Objective: Early diagnosis and prognostic evaluation of hepatocellular carcinoma (HCC) remain significant challenges in clinical management. This study aims to identify prognostic biomarkers in HCC and to explore their im...
CEBPB emerges as a key regulatory factor in human cancers through diverse molecular mechanisms and clinical implications [0.03%]
CEBPB通过多种分子机制和临床意义在人类癌症中成为关键调节因子
Anbang He,Cunjin Wu,Dan Xia et al.
Anbang He et al.
CCAAT/enhancer-binding protein beta (CEBPB) is a critical transcription factor for cellular differentiation, inflammation, and metabolism. Recent studies have highlighted its dual role in tumorigenesis, functioning as both an oncogenic driv...