Amino acid metabolic reprogramming drives pathogenesis and therapy in hematologic malignancies [0.03%]
氨基酸代谢重组驱动血液系统恶性肿瘤的发生和发展及治疗反应
Dexiang Ren,Rong Liu,Wei Li et al.
Dexiang Ren et al.
Hematological malignancies exhibit distinct patterns of amino acid metabolic reprogramming, which support uncontrolled proliferation, immune escape, and therapy resistance. Rather than merely fueling biosynthesis, amino acid metabolism intr...
Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth [0.03%]
结肠直肠癌细胞源性外泌体通过诱导癌症相关成纤维细胞的代谢重组促进结肠直肠癌生长
Guopeng Pan,Zexiong Cheng,Yiwei Wang et al.
Guopeng Pan et al.
Urea cycle (UC) dysfunction drives tumorigenesis and poor prognosis, yet its role in tumor-stroma crosstalk is unclear. Here we show that colorectal cancer (CRC) cells reprogram UC metabolism in cancer-associated fibroblasts (CAFs) via CRC-...
Neddylation related gene signature for prognostic biomarkers in colorectal cancer with integrated bioinformatics and experimental analysis [0.03%]
结直肠癌泛素化相关基因预后标志物的生物信息学及实验研究
Li Zhou,Lujuan Pan,Haisheng Lan et al.
Li Zhou et al.
CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation [0.03%]
circFAT1(e2)通过调控MYBL2介导的细胞增殖充当miR-30e-5p海绵抑制胶质瘤进展
Zengjin Liu,Shewei Guo,Yahui Bai et al.
Zengjin Liu et al.
Introduction: Gliomas present formidable challenges due to their aggressive nature and limited treatment efficacy. This study examines the roles of circFAT1(e2) and the MYB gene family, particularly MYBL2, in glioma etiol...
The analysis of TOP2A as a potential target for predicting the prognosis of brain glioma in the TCGA database and in single-center study [0.03%]
对TCGA数据库和单中心数据中TOP2A作为胶质瘤预后预测标志物的分析研究
Tingting Shen,Lei Sheng,Hua Zhan et al.
Tingting Shen et al.
A Mendelian randomization-based risk model using aging-related genes for prognosis in lung adenocarcinoma [0.03%]
基于衰老相关基因的孟德尔随机化风险模型在肺腺癌预后中的应用
Shaowen Feng,Xiaowang Liu,Huiqin Yang et al.
Shaowen Feng et al.
Background: Aging-related genes (ARGs) are prognostic markers in cancers, but their role in lung adenocarcinoma (LUAD) remains unclear. Investigating ARGs in LUAD may provide valuable insights for clinical diagnosis and t...
Prediction of regional lymph node metastasis in rectal cancer: a novel model based on transrectal contrast-enhanced ultrasound [0.03%]
基于经直肠对比增强超声的新型模型预测直肠癌区域淋巴结转移
Qin Huang,Hua Zhuang,Yuan Luo et al.
Qin Huang et al.
Background: Regional lymph node metastasis (RLNM) is a crucial prognostic factor for rectal cancer (RC). Accurate preoperative assessment of lymph node status assists clinicians in identifying high-risk patients and formu...
A pancancer analysis reveals the oncogenic role of glutaminase 1 (GLS1) in tumor metabolism and immune evasion: a bioinformatics analysis [0.03%]
泛癌分析揭示谷氨酰胺酶1(GLS1)在肿瘤代谢和免疫逃逸中的致癌作用：生物信息学分析
Jianjun Liu,Shikai Hong,Kangsheng Gu
Jianjun Liu
Background: Metabolic reprogramming is a significant factor that regulates the function and differentiation of immune cells, thereby influencing the progress of the immune response. The intricate interplay between glutami...
A bibliometric study on microenvironment-mediated drug resistance in interventional liver cancer treatment [0.03%]
肝癌介入治疗中微环境介导的药物抗性主题的 bibliometric 分析研究
Qiang Wang,Xu Feng,Guo Xiao et al.
Qiang Wang et al.
Background: Microenvironment-driven drug resistance is a principal barrier to durable response after transarterial chemoembolisation, ablation or radioembolisation for hepatocellular carcinoma, yet the global structure of...
CXCL10 promotes non-small cell lung cancer (NSCLC) progression by modulating the phosphate to urate ratio (PUR) [0.03%]
CXCL10通过调节磷酸与尿酸比率(PUR)促进非小细胞肺癌(NSCLC)进展
Yonglun Zhang,Qian Li
Yonglun Zhang
This study aims to explore the causal relationships and mechanisms between NSCLC-related genes, metabolites, and NSCLC using Mendelian Randomization (MR). The study employed differential gene expression analysis, two-sample MR analysis, and...