Ferroptotic resistance involved in PTEN-loss prostate cancer progression [0.03%]
PTEN缺失促进前列腺癌发生发展中的铁死亡抵抗机制研究
Yaoyao Jing,Donghui Xing,Zhigang Zhao et al.
Yaoyao Jing et al.
Ferroptosis, a newly recognized form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a pivotal role in cancer development. Herein, we investigated the mechanisms of ferroptotic resistance mediated by...
Shikha Kumari,Sanjay Ghosh,Achim Doerner
Shikha Kumari
Targeting human diseases using antibodies is a rapidly evolving area of research that could transform healthcare. Currently, various diseases, including cancer, are treated by immunotherapy using the IgG class of antibodies. Recently, effor...
Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma [0.03%]
N2b扁桃体鳞癌同侧放射治疗的患者报告结果
Chike O Abana,Adam S Garden,G Brandon Gunn et al.
Chike O Abana et al.
Background: Previous studies have reported excellent disease control and survival in patients with well-lateralized, American Joint Committee on Cancer (AJCC)-7 T1-2N2b tonsillar squamous cell carcinoma (SCC). The reduced...
Factors associated with herbal medicine use among patients with cancer attending a tertiary hospital in Southwestern Uganda: a cross-sectional study [0.03%]
乌干达西南部一所三级医院就诊的癌症患者使用草药的相关因素：一项横断面研究
Samuel Michael Nono,Julius Kyomya,Casim Umba Tolo et al.
Samuel Michael Nono et al.
Background: Herbal medicine use among patients with cancer is prevalent particularly in low- and middle-income countries. However, concerns about safety and potential interactions with chemotherapy emphasize the need to u...
Research progress on chronic stress stimulation and gastric cancer metastasis [0.03%]
慢性应激刺激与胃癌转移的研究进展
Juntao Chen,Yanling Zhang,Tianyou Zhang et al.
Juntao Chen et al.
Gastric cancer remains a major clinical challenge due to its propensity for metastasis and poor five-year survival rates. Emerging evidence implicates chronic psychological stress as a critical promoter of tumor dissemination. Stress signal...
Identification of ITGA2 as a methylation-regulated oncogene through a CeRNA network in papillary thyroid carcinoma [0.03%]
通过CeRNA网络鉴定ITGA2在乳头状甲状腺癌中的甲基化调控致癌基因作用
Guoliang Wu,Xinyu Wang,Yiming Zhu et al.
Guoliang Wu et al.
Objective: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. This study aimed to construct a competing endogenous RNA (ceRNA) network to identify potential molecular targets and validate their bio...
Integration of Mendelian randomization and transcriptome wide association studies for causal gene identification in ovarian cancer genetic architecture [0.03%]
结合孟德尔随机化和转录组相关性研究鉴定卵巢癌遗传结构中的因果基因
Qin Yang,Zurui Zeng,Jie Wang et al.
Qin Yang et al.
Background: Ovarian cancer remains one of the most lethal gynecological malignancies with limited understanding of its genetic architecture and causal mechanisms. While genome-wide association studies have identified nume...
Epigenomic characterization and therapeutic challenges of melanoma arising in giant nevi in pediatric patients [0.03%]
儿童患者的巨大色素痣源性黑色素瘤的表观基因组特征及其治疗挑战
Evelina Miele,Sabrina Rossi,Alessandra Stracuzzi et al.
Evelina Miele et al.
Background: Congenital giant melanocytic nevi (CGMN) are rare melanocytic proliferations present at birth, associated with an increased risk of pediatric malignant melanoma (MM). Melanomas arising within CGMN are uncommon...
Overexpression of Sterol Regulatory Element-binding Transcription Factor 2 is associated with an adverse prognosis in cytogenetically normal acute myeloid leukemia [0.03%]
Sterol调节元件结合转录因子2过度表达与遗传学正常急性髓系白血病不良预后相关
Ruoqi Shan,Jiachi Wang,Ping Chen et al.
Ruoqi Shan et al.
Background: Cytogenetically normal acute myeloid leukemia (CN-AML), the most heterogeneous subgroup, requires molecular markers for effective management. Recent studies have highlighted abnormal lipid metabolism as a crit...
Decoding the cholesterol-apoptosis axis in HCC: a machine learning-based multi-omics integration and single-cell transcriptomic analysis [0.03%]
基于机器学习的多组学整合和单细胞转录组分析揭示肝癌中的胆固醇-凋亡轴
Yang Li,Jun Shi,Aiqing Zhao et al.
Yang Li et al.
Liver hepatocellular carcinoma (LIHC), a predominant form of primary hepatic malignancy, demonstrates a progressively escalating global incidence, imposing substantial health and economic burdens on patients and society. Early diagnosis rem...