Lactylation modification regulates acute myeloid leukemia pathogenesis and immune microenvironment [0.03%]
乳酰化修饰调控急性髓系白血病的发生发展和免疫微环境
Ruixue Dai,Guodong Sui
Ruixue Dai
Causal relationship between blood metal levels and breast cancer risk: a Mendelian randomization study in East Asian populations [0.03%]
基于东亚人群的乳腺癌易感性与血液金属元素水平相关性的孟德尔随机化研究
Jingyi Zhang,Fu Xiong,Shucheng Hu et al.
Jingyi Zhang et al.
Object: Studies in European populations have shown an association between blood metal levels and cancer risk. This study aimed to investigate the causal relationship between breast cancer (BC) risk and blood metal levels ...
Global research trends and prospects related to telomerase within breast cancer: a bibliometric and visual analysis [0.03%]
全球肿瘤延长酶与乳腺癌研究趋势和前景的共引分析及可视化研究
Limeng Qu,Shirong Ding,Qian Long et al.
Limeng Qu et al.
Background: Telomerase plays a crucial role in the early diagnosis, prognosis, and treatment of breast cancer. However, no comprehensive bibliometric analysis has been conducted to explore its research trends. This study ...
Exploring the TRIM15 protein interaction network as a drug target using machine learning in pancreatic cancer [0.03%]
利用机器学习在胰腺癌中探索TRIM15蛋白质相互作用网络作为药物靶点
Kübra Sena Bas Topcu,Kubra Temiz,Ercan Cacan
Kübra Sena Bas Topcu
Evaluating the carcinogenic potential and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human stomach using organoids and bulk sequencing data: a multi-machine learning approach combined with computational simulation [0.03%]
利用类器官和批量测序数据评估2,3,7,8-四氯二苯并-对-二恶英在人类胃中的致癌潜力及分子机制：结合计算机模拟的多机器学习方法研究
Youfu Tian,Dede Ma,Ke Yan et al.
Youfu Tian et al.
Objective: This study investigates the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the pathogenesis of gastric cancer and its associated molecular mechanisms, particularly the interaction between TCDD and key ...
Deep learning model outperforms traditional models in clinical data-based prognostic prediction for adult-type diffuse glioma [0.03%]
深度学习模型在基于临床数据的成人弥漫性胶质瘤预后预测中优于传统模型
Xiaopeng Li,Chongshun Zhao,Yanpeng Xia et al.
Xiaopeng Li et al.
Objective: This study aims to systematically compare traditional statistical methods and machine learning approaches for survival prediction in adult-type diffuse glioma (ADG), evaluating their performance, interpretabili...
Identification of potential bladder cancer drug targets through Mendelian randomization and molecular docking [0.03%]
利用孟德尔随机化和分子对接鉴定潜在的膀胱癌药物靶点
Chengwei Bi,Kexun Li,Yong Yang et al.
Chengwei Bi et al.
Bladder cancer is a common and lethal malignancy with high treatment costs due to frequent recurrence and prolonged therapy. Despite therapeutic advances, many patients develop drug-resistant metastatic disease, underscoring the need for ne...
Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study [0.03%]
基于孟德尔随机化研究探索肠道菌群、循环炎症蛋白与结直肠神经内分泌肿瘤的因果关联
Jie Cui,Tie-Jun Wang,Yue-Chen Zhao et al.
Jie Cui et al.
The gut microbiota may influence the occurrence and development of colorectal neuroendocrine tumors (CR-NETs), with inflammatory mediators potentially playing an important intermediary role. However, the current research evidence is insuffi...
Prognostic and therapeutic response prediction in glioblastoma multiforme using a lactylation-associated gene signature [0.03%]
基于乳酰化相关基因特征的胶质母细胞瘤预后及治疗反应预测模型
Huan Zhu,Guanjun Li,Tingting Li et al.
Huan Zhu et al.
Background: Glioblastoma (GBM) is a highly aggressive brain tumor characterized by immunosuppressive tumor microenvironment and metabolic reprogramming. Dysregulated lactate metabolism has been observed in the glioma micr...
Identification of FGF14-AS2/MPP2 axis as prognostic biomarkers in colorectal cancer based on CeRNA network [0.03%]
基于CeRNA网络的FGF14-AS2/MPP2轴作为结直肠癌预后生物标志物的鉴定
Rongrong Zhou,Zhineng Zeng,Ying Xu et al.
Rongrong Zhou et al.
Background: Colorectal cancer (CRC) remains a major global health challenge due to its high morbidity and mortality, even with recent advancements in diagnosis and treatment. Increasing evidence suggests that competitive ...