Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy [0.03%]
多组学和代谢通量模型揭示巨噬细胞CYP27A1衍生的26-羟基胆固醇驱动免疫抑制和癌症恶性肿瘤形成
Jinfen Wei,Bin Yu,Na Wang et al.
Jinfen Wei et al.
Emerging evidence indicates that aberrant cholesterol metabolism in macrophages plays a role in tumorigenesis, however, how specific metabolites released by macrophages influence immunosurveillance and along with their potential as therapeu...
Clinical outcomes of immune checkpoint inhibitor based therapy in NRG1 fusion positive non small cell lung cancer a retrospective study [0.03%]
NRG1重排阳性非小细胞肺癌免疫检查点抑制剂治疗的临床疗效回顾性研究
Xiyun Yan,Xiyan Fu,Zhanghui Long et al.
Xiyun Yan et al.
Background: Although immune checkpoint inhibitors (ICIs) have contributed to significant advances in the treatment of lung cancer, there is a lack of research investigating their efficacy in patients with non-small-cell l...
Association between serum uric acid levels and gastric cancer risk: a systematic review, integrated meta-analysis, and bioinformatics analysis [0.03%]
血清尿酸水平与胃癌风险之间的关联：系统评价、综合 Meta 分析及生物信息学分析
Xi Zhang,Xiao-Shu Jin,Xue-Xia Gao et al.
Xi Zhang et al.
Objective: Uric acid (UA) is the end product of purine metabolism. Numerous studies have reported an association between serum UA levels and the risk of several solid tumors, but its association with gastric cancer (GC) r...
Comprehensive identification of three key genes and three key DNA methylation CpG sites associated with prognosis and prediction in colon adenocarcinoma [0.03%]
结肠腺癌预后和预测相关的三个关键基因和三个关键DNA甲基化CpG位点的全面识别
Yu-Xian Liu,Xingjie Chen,Wenjia Wang et al.
Yu-Xian Liu et al.
Colon adenocarcinoma (COAD) is a common cancer with high incidence and mortality rates worldwide. DNA methylation has a significant impact on the occurrence and development of COAD. However, the regulatory and prognostic effects of DNA meth...
Multi-omics pan-cancer analysis reveals heterogeneous BCAA metabolism and its impact on the tumor immune microenvironment and prognosis [0.03%]
多组学泛癌分析揭示支链氨基酸代谢的异质性及其对肿瘤免疫微环境和预后的影响
Jinqin Qian,Fuhao Wang,Liqun Zhou et al.
Jinqin Qian et al.
Background: Reprogramming of branched-chain amino acid (BCAA) metabolism is a metabolic hallmark of cancer that fuels tumor progression. However, a comprehensive understanding of its pan-cancer heterogeneity and its cross...
Engineered immune cells and extracellular vesicles target tumour microenvironment barriers in solid tumour immunotherapy [0.03%]
工程化免疫细胞和细胞外囊泡在实体肿瘤免疫治疗中克服肿瘤微环境障碍
Xiaowei Zhou,Shixin Chen,Junbo Liang
Xiaowei Zhou
Adoptive cell therapy (ACT) for solid tumours frequently fails because the tumour microenvironment (TME) imposes multiple, overlapping barriers, including stromal exclusion, suppressive myeloid networks, inhibitory cytokines and metabolites...
A bibliometric map of C. elegans in cancer research from 2005 to 2025 [0.03%]
2005-2025年线虫模式生物体在癌症研究中的文献计量地图分析
Yulin Song,Zhenyu Zhu,Yan Daijun et al.
Yulin Song et al.
Background: Cancer continues to pose a significant global health challenge, with numerous tumors still being identified at advanced stages despite considerable advancements in therapeutic interventions and imaging methodo...
Predictive value of apparent diffusion coefficient, plasma levels of placental growth factor and glial fibrillary acidic protein, and their combinations for patients with recurrent glioblastoma [0.03%]
表观扩散系数、血浆胎盘生长因子及胶质纤维酸性蛋白预测值及联合预测值在复发胶质母细胞瘤患者中的价值
Yujin Yin,Shuiming Deng,Zhiqiang Zhang et al.
Yujin Yin et al.
Objective: Glioblastoma (GB) is the deadliest primary brain tumor, largely due to inevitable recurrence of the disease after partial surgical resection or resistance to drug treatments. The study aimed to evaluate the pre...
Metformin in endometrial cancer from metabolic regulation to precision therapeutics [0.03%]
从代谢调节到精准治疗的二甲双胍在子宫内膜癌中的作用
Yile Jin,Na Li
Yile Jin
Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with incidence rising in parallel with obesity, insulin resistance, and type 2 diabetes (T2DM). EC exhibits characteristic metabolic vulnerabilities, ...
Adipocytes in cancer a metabolic paradox and the dawn of novel therapeutics [0.03%]
脂肪细胞在癌症中的作用：一个代谢悖论和新型治疗的曙光
Zhuoran Fang,Danni Zhu,Teng Yang et al.
Zhuoran Fang et al.
In recent years, the dual regulatory role of adipocytes in the tumor microenvironment (TME) has emerged as a critical focus in cancer research. Advances in the fields of metabolic biology and tumor immunology have shown that adipocytes play...