Nivolumab and ipilimumab combination therapy for melanoma efficacy, safety and clinical integration in metastatic and adjuvant settings [0.03%]
尼伏单抗与易普利姆玛联合疗法治疗黑色素瘤：转移和辅助环境下的有效性和安全性及临床整合问题
Rechner Afuh,Patrick Ashinze,Suvam Banerjee et al.
Rechner Afuh et al.
Melanoma remains one of the most aggressive cutaneous malignancies, accounting for a disproportionate share of skin cancer-related mortality despite relatively lower incidence. Over the past decade, immune checkpoint inhibitors (ICIs) have ...
The impact of m6A modified cargo conveyed by exosomes on the tumor microenvironment [0.03%]
m6A修饰的外泌体递送cargo对肿瘤微环境的影响
Wang Yi,Qingfeng Shi,Jiahui Wu et al.
Wang Yi et al.
The dynamic evolution of tumor microenvironment (TME) is the core of cancer progression. N6-methyladenosine (m6A) modification and exosome transport are key layers of post-transcriptional gene regulation and intercellular communication, res...
Expression pattern, functional characteristics and prognostic significance of NLGN1 gene in nasopharyngeal carcinoma: a comprehensive multi-omics analysis [0.03%]
NLGN1基因在鼻咽癌中的表达模式、功能特征及预后意义的多组学综合分析
Yi Nan Liu,Yan Yan Fan
Yi Nan Liu
Background: Neuroligin 1 (NLGN1), as an important member of the cell adhesion molecule family, primarily participates in synapse formation and neuronal connection regulation. However, the role and clinical significance of...
Advanced liposomal nanoplatforms for flavonoid delivery: a mechanistic and comparative perspective in hepatocellular carcinoma [0.03%]
用于黄酮类药物输送的脂质体纳米平台在肝细胞癌中的作用：机制及比较研究视角
Poonam Lal,Jitendra Patel
Poonam Lal
Hepatocellular carcinoma (HCC) is a common and life-threatening type of liver cancer, and its treatment results are frequently restricted by late diagnosis, drug resistance, systemic toxicity, and limited specificity of traditional treatmen...
Institutional experience and pooled survival analysis of chemotherapy based multimodal management in poorly differentiated chordoma [0.03%]
放化疗综合治疗软骨肉瘤的临床经验及生存分析
Jingyu Xing,Hao Zhang,Zijie Yuan et al.
Jingyu Xing et al.
Background: Poorly differentiated chordoma (PDC) is an exceptionally rare bone tumor with aggressive behavior and early recurrence. Evidence on the role and integration of chemotherapy remains limited. We aimed to share o...
A case report of carotid body tumor with rare thoracic vertebral metastasis and literature review [0.03%]
罕见胸椎转移性颈动脉体瘤病例报告及文献复习
Fei Li,Jie Yang,Juan Zhang et al.
Fei Li et al.
Background: Malignant carotid body tumor (CBT), a type of carotid body paraganglioma (PGL), is defined by the presence of distant metastasis; histology alone cannot reliably distinguish benign from malignant CBT. We prese...
CCDC78 is required for prostate cancer cell growth and serves as a prognostic biomarker for high-risk disease [0.03%]
CCDC78对前列腺癌细胞生长是必需的，并且可以作为高危疾病预后的生物标志物
Liangzhen Zhu,Wenken Liang
Liangzhen Zhu
Background: As the second most common malignancy among men worldwide, prostate cancer is commonly diagnosed through PSA testing and puncture biopsy. However, these methods have limitations in risk assessment. Clinically, ...
Roles of m6A regulators in shaping methylation patterns and tumor microenvironment immune infiltration in colorectal cancer [0.03%]
m6A调控因子在塑造结直肠癌甲基化模式和肿瘤微环境免疫浸润中的作用
Chen-Qi Zhang,Jian-Wei Ma,Fei Xu et al.
Chen-Qi Zhang et al.
Recent studies have demonstrated that immune responses are subject to epigenetic regulation. However, the functional roles of RNA N6-methyladenosine (m6A) modification in infiltrating cells within the tumor microenvironment (TME) remain inc...
Development and verification of a lipotoxicity-related gene signature for predicting prognosis and immune landscape in colorectal cancer [0.03%]
开发和验证与脂毒性相关的基因特征用于预测结直肠癌的预后和免疫景观
Chenlu Xiong,Pinglian Liao,Jin Li
Chenlu Xiong
Background: Colorectal cancer (CRC), a lethal tumor of the intestine, has lipotoxicity, which exerts a significant influence on the onset and development of intestinal disorders. This study provides an in-depth evaluation...
Global trends in fertility-preserving treatment for endometrial cancer: a bibliometric analysis, 2005-2024 [0.03%]
2005-2024年子宫癌保留生育功能治疗的全球趋势：文献计量分析
Lei Chang,Wenping Lu,Lutian Gong et al.
Lei Chang et al.
Objective: To quantitatively map and visualize global research trends, key contributors, and thematic evolution in fertility-preserving treatment for endometrial cancer from 2005 to 2024. ...