Exploring key genes related to ferroptosis amino acid metabolism in lung adenocarcinoma based on transcriptome data [0.03%]
基于转录组数据探索肺癌腺癌铁死亡氨基酸代谢相关关键基因
Wen Li,Ruiyue Wu,Xi Chen et al.
Wen Li et al.
Lung adenocarcinoma (LUAD) is a highly aggressive cancer with limited treatment options. This study investigated key genes linking ferroptosis and amino acid metabolism in LUAD using bioinformatics and experimental validation. Analysis of T...
Clinical and biological implications of fragmented response in rectal cancer after neoadjuvant chemoradiotherapy [0.03%]
新辅助放化疗后直肠癌不完全缓解的临床和生物学意义
José M Azevedo,Diogo Relveiro,Matilde Gama et al.
José M Azevedo et al.
Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer. Tumour regression patterns after nCRT are heterogeneous, with current tumour regression grading (TRG) systems ...
Identification of FMR1 as a novel cancer prognostic and immunotherapy biomarker through renal cancer experimental validation and pan-cancer analysis [0.03%]
通过肾癌实验验证和泛癌分析鉴定FMR1作为新的癌症预后和免疫治疗生物标志物
Huaqing Yan,Fan Xu,Xiaobo Cui et al.
Huaqing Yan et al.
Background: FMR1, a gene classically linked to Fragile X syndrome, functions as a multifunctional RNA-binding protein regulating RNA metabolism. Emerging evidence indicates its role in modulating cancer progression and tu...
A novel prognostic zinc finger gene model for hepatocellular carcinoma via machine learning [0.03%]
基于机器学习的肝细胞癌锌指基因预后模型
Zutao Chen,Shuo Jiang,Binru Yang et al.
Zutao Chen et al.
Background: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with poor prognosis, and effective biomarkers for predicting immunotherapy response are lacking. Immune checkpoint blockade has advanced HCC treatme...
High RSPO3 protein expression serves as an independent poor prognostic factor and promotes malignant progression in breast cancer [0.03%]
高水平的RSPO3蛋白表达是乳腺癌不良预后的独立影响因素并促进恶性进展
Shuyun Jiang,Hongwei Ma,Zhanwei Du et al.
Shuyun Jiang et al.
Objective: To elucidate the expression pattern, clinical prognostic significance, and distribution characteristics of R-spondin 3 (RSPO3) within the tumor microenvironment (TME) of breast cancer (BC), to observe its effec...
Identification of exosome-related genes signature based on bioinformatics and machine learning for prognostic prediction in colorectal cancer [0.03%]
基于生物信息学和机器学习的外泌体相关基因标志物在结直肠癌预后预测中的作用
Kaisong Wang,Tingyu Chen,Yiqiang Chen et al.
Kaisong Wang et al.
Background: Colorectal cancer (CRC) is a prevalent malignant tumor with increasing incidence and mortality rates worldwide. Exosomes are secretory vesicles generated by the endosomal system within cells. Previous studies ...
Tumor location and morphological MRI features in relation to combined 1p/22q deletion in meningioma [0.03%]
脑膜瘤中肿瘤位置和形态磁共振影像特征与1p/22q复合缺失的关系研究
Alim Emre Basaran,Laura Wolter,Max Braune et al.
Alim Emre Basaran et al.
Background: Combined chromosomal 1p/22q deletion is associated with aggressive tumor biology and an increased risk of recurrence in meningiomas. Since C-IMPACT-NOW Update 8, this molecular alteration has gained relevance ...
Tumor-induced immune escape mechanisms and translational immunotherapeutic strategies [0.03%]
肿瘤诱导的免疫逃逸机制和转化型免疫治疗策略
Mohammad Yousefi,Mohammad Reza Farahpour,Nazila Alizadeh et al.
Mohammad Yousefi et al.
Tumor-induced immune evasion is a critical mechanism that promotes resistance to anticancer therapies and facilitates cancer progression. Notwithstanding the emergence of immunotherapies, especially immune checkpoint inhibitors (ICIs) and a...
A machine-learning-derived multi-cell death mode signature predicts melanoma prognosis and reveals an immune-cold tumor microenvironment [0.03%]
基于机器学习的多细胞死亡模式签名预测黑色素瘤预后并揭示免疫冷肿瘤微环境
Dan Wu,Yuze Zhou,Jiahong Fang et al.
Dan Wu et al.
Background: Regulated cell death programs influence melanoma progression and antitumor immunity, yet a robust prognostic model integrating multiple cell-death modalities remains limited. ...
The role of HBV in reprogramming liver cancer stem cells and shaping their plasticity and therapeutic vulnerabilities [0.03%]
HBV在肝癌干细胞重编程、塑造其可塑性及治疗弱点中的作用
Hanlin Gao,Zhuoyan Lei,Luye Wang et al.
Hanlin Gao et al.
Hepatitis B virus (HBV) infection remains a leading cause of hepatocellular carcinoma (HCC) worldwide, particularly in East Asia. Liver cancer stem cells (LCSCs) have emerged as crucial drivers of HCC initiation, metastasis, recurrence, and...