Hepatocellular carcinoma-cholangiocarcinoma collision tumor with excellent therapeutic response: a case report and literature review [0.03%]
Zengpeng Sun,Yutao Wang,Chuang Peng et al.
Zengpeng Sun et al.
This article reports a rare case of a collision tumor composed of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC). The patient is a 54-year-old male with hepatitis B virus-related cirrhosis and three focal lesions l...
p53 expression and NLR could recognize distinct subtypes of lung adenocarcinoma with high expression of PD-L1 (TPS ≥ 50%), defined with 22C3 antibody [0.03%]
p53表达和NLR可识别PD-L1高表达(TPS ≥ 50%, 22C3定义)肺腺癌的亚型
Ming Li,Mengqi Huang,Yuchen Huang et al.
Ming Li et al.
Background: Lung adenocarcinoma (LUAD) with high expression of PD-L1 (TPS ≥ 50%) is a distinct subset of NSCLC and a potential immunotherapy candidate. An improved understanding of the heterogeneity of PD-L1-high LUAD pa...
Functional and mechanistic inactivation of immune hubs orchestrates tumor development and progression in lung adenocarcinoma [0.03%]
肺癌免疫中心的功能和机制失活在肺腺癌发生发展中的作用及机制研究
Abdullah Alghamdi,Mohammed Alissa
Abdullah Alghamdi
Background: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapies and immune che...
Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties [0.03%]
LGR4对癌症及其干细胞属性调控机制的研究进展
Jialei Yang,Jinye Zhao,Houchang Liu et al.
Jialei Yang et al.
Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor belonging to the G-protein-coupled receptor superfamily. LGR4 can be activated by ligands such as R-spondins (RSPOs), Norrin, and the ligand of the receptor a...
Identification of replication factor C subunit 4 as a potential therapeutic target in esophageal squamous cell carcinoma based on bioinformatic analysis and machine learning [0.03%]
基于生物信息学分析和机器学习鉴定DNA复制因子C亚基4作为治疗食管鳞癌的潜在靶点
Zhenzhen Yang,Cheng Chang,Na Gao et al.
Zhenzhen Yang et al.
Background: Esophageal squamous cell carcinoma (ESCC) is one of the highly lethal and aggressive malignant tumors worldwide. To effectively prevent and treat this disease, the search for novel molecular targets is of grea...
Comprehensive bioinformatics analysis of EXOSC family genes in lung adenocarcinoma [0.03%]
肺癌中EXOSC家族基因的生物信息学综合分析
Ning Li,Xiaolei Wang,Tingting Chu et al.
Ning Li et al.
The RNA exosome complex (EXOSC1-10) orchestrates 3'-5' RNA processing and decay, yet its family-wide landscape and clinical relevance in lung adenocarcinoma (LUAD) remain incompletely defined. Here, we conducted an integrative multi-omics a...
Integrating machine learning and structural analysis to decipher benzo[a]pyrene-induced bladder cancer networks [0.03%]
基于机器学习和结构分析解译苯并[a]芘诱导的膀胱癌网络
Xinzhao Zhao,Ruize Qin,Chengquan Shen et al.
Xinzhao Zhao et al.
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon from tobacco smoke, exhaust, and pollutants, is linked to bladder cancer (BLCA). We systematically analyzed GEO datasets to identify BaP-related differentially expressed genes (DEBRGs)...
NOTCH2NLA gene amplification is associated with poor prognosis in breast cancer [0.03%]
NOTCH2NLA基因拷贝数与乳腺癌预后不良有关
Yuchuan Wang,Ye Sang,Qianyi Dou et al.
Yuchuan Wang et al.
Recently, a high-frequency gain of the human-specific NOTCH2NL gene was found in anaplastic thyroid cancer, yet its amplification status in other cancers is still unknown. In our study, we discovered that NOTCH2NLA, a paralog of the NOTCH2N...
Comprehensive bioinformatics analysis targeting sphingosine-related genes in head and neck cancer [0.03%]
针对头颈鳞癌中的鞘氨醇相关基因的生物信息学分析
Masakazu Hamada,Yoshiaki Yura,Narikazu Uzawa
Masakazu Hamada
A comprehensive bioinformatics analysis of the expression of sphingosine-related genes and prognosis of patients with head and neck squamous cell carcinoma (HNSCC) was performed using TCGA data and TIMER. A keyword search using sphingosine ...
Interrater reliability of nutritional risk screening using NRS-2002 in hospitalized patients with cancer [0.03%]
NRS-2002营养风险筛查在肿瘤住院患者中的组间信度分析
Lu Zhang,Rong Guo,Yinyin Ou et al.
Lu Zhang et al.
Purpose: Malnutrition is common among hospitalized cancer patients and has been linked to adverse clinical outcomes. Accurate nutritional risk screening is essential for rapid nutritional intervention. Although the NRS-20...