Integration of 117 machine learning algorithms and single-cell transcriptomics identifies macrophage polarization and ER stress signatures for cancer prognosis and precision therapy [0.03%]
整合117种机器学习算法和单细胞转录组学鉴定用于癌症预后和精确治疗的巨噬细胞极化及内质网应激特征
Shengrong Long,Kewei Xiao,Zhipeng Hao
Shengrong Long
Background: Macrophage polarization and endoplasmic reticulum (ER) stress play critical yet incompletely understood roles in cancer progression and therapeutic resistance. ...
Integrating single-cell RNA and bulk RNA sequencing data to identify prognostic genes associated with pyrimidine metabolism in triple-negative breast cancer by machine learning algorithm combinations [0.03%]
基于机器学习算法组合整合单细胞RNA和批量RNA测序数据，以识别三阴性乳腺癌中与嘧啶代谢相关的预后基因
Xue Gong,Yubo Du,Huanyu Zhang et al.
Xue Gong et al.
Background: Pyrimidine metabolism plays a crucial role in DNA synthesis and cell proliferation and is associated with the development of various cancers. However, their prognostic value in triple-negative breast cancer re...
A patient-derived organoid model identifies TP53-dependent gemcitabine sensitivity in spinal chordoma [0.03%]
一种患者衍生类器官模型识别出TP53依赖性吉西他滨敏感性在脊柱软骨肉瘤中的作用
Panpan Hu,Shengxin Zeng,Juncai Lei et al.
Panpan Hu et al.
Background: Chordoma is a rare malignant bone tumor with limited effective systemic treatment options. Conventional chemotherapy generally shows minimal benefit, highlighting the need for predictive preclinical models to ...
Integrative proteomics and metabolomics advance early cancer detection and targeted therapy with emerging technologies and clinical applications [0.03%]
整合蛋白质组学和代谢组学利用新兴技术与临床应用促进早期癌症检测及靶向治疗
Shayesteh Shakarami,Nisreen M Saleh,Farshad Zare et al.
Shayesteh Shakarami et al.
Early detection and personalized therapy remain central challenges in modern oncology. Recent advancements in proteomics and metabolomics have unlocked powerful strategies for identifying molecular alterations associated with cancer onset, ...
Identification of tolerogenic dendritic cells-related prognostic biomarkers in Wilms tumor via machine learning integration [0.03%]
基于机器学习整合识别Wilms瘤中与耐受性树突状细胞相关的预后生物标志物
Xiaolan Sun,Yaqing Gao,Kexin Meng et al.
Xiaolan Sun et al.
Wilms tumor (WT) is the most common pediatric kidney cancer. Tolerogenic dendritic cells (TolDCs) promote tumor immune evasion in the tumor microenvironment. Therefore, establishing a TolDC-based prognostic model for WT holds significant cl...
Research on the role and mechanism of FAT4 in the development and progression of tumor and non-tumor diseases [0.03%]
FAT4在肿瘤与非肿瘤疾病发生发展中的作用及机制研究
Lingli Zhong,Renshan Wang,Yidie Li et al.
Lingli Zhong et al.
FAT4 (FAT Atypical Cadherin 4), a member of the atypical cadherin family, represents the human ortholog of Drosophila Fat (Ft) and functions as a positive regulator of planar cell polarity in the Drosophila wing. It serves various functions...
Development and validation of an interpretable prognostic model for bladder cancer based on lactylation associated genes using SHAP analysis [0.03%]
基于SHAP分析的乳酰化相关基因膀胱癌预后模型的建立与验证
Yongqi Wang,Xiao Yu
Yongqi Wang
Objective: The high recurrence rate and poor clinical outcomes of bladder cancer (BLCA) underscore the urgent need for novel biomarkers to guide precision medicine. Focusing on lactylation-a novel epigenetic modification...
Comprehensive analysis of ATF3 as a diagnostic and prognostic biomarker from pan-cancer to clear cell renal cell carcinoma [0.03%]
ATF3作为泛癌及透明细胞肾细胞癌诊断和预后标志物的全面分析
Hao Ling,Guangmei Wu,Yanzhu Hu
Hao Ling
Background: ATF3 was found to play a complex role in various cancers; however, its systematic function in kidney renal clear cell carcinoma (KIRC) and across pan-cancer contexts remained incompletely understood. ...
Single-cell transcriptomics reveals ADRB1 as a key immune checkpoint regulating T cell exhaustion in lung cancer and its prognostic value in lung cancer [0.03%]
单细胞转录组揭示肾上腺素受体ADRB1在肺癌中调节T细胞耗竭的关键免疫节点作用及其在肺癌预后中的价值
Zhanqi Cao,Fan Su,Xinjie Dun et al.
Zhanqi Cao et al.
Background: Lung cancer, LUAD, and LUSC are both among the leading causes of cancer-related deaths. T cell exhaustion within the tumor microenvironment compromises the immune response and limits the benefits of immune che...
Radiotherapy-based multimodal treatment in advanced NSCLC with spinal infiltration: a case series of seven unfavorable patients [0.03%]
以放射治疗为基础的多模式治疗伴脊柱浸润的晚期NSCLC：七例不利患者系列报道
Linda Agolli,Bastian Eul,Diethard Prüfer et al.
Linda Agolli et al.
Background: Locally advanced non-small cell lung cancer (LA-NSCLC) with spinal invasion presents a rare but challenging clinical scenario. Radical surgical approaches, though potentially curative, are often not feasible d...