Exosomal 3'tiRNA-PheGAA and interleukin-6 as novel biomarkers for non-invasive detection of NSCLC [0.03%]
外泌体3'tiRNA-PheGAA和白细胞介素-6作为非侵入性检测NSCLC的新型生物标志物
Ning Yuan,Qun Zhang,Jing Shi et al.
Ning Yuan et al.
Background: Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related mortality worldwide. However, the diagnostic sensitivity and specificity of commonly used tumor markers, such as carcinoem...
Songli Ju,Lu Tao,Xuyan Li et al.
Songli Ju et al.
Osteosarcoma typically arises during adolescence, posing a significant challenge. Despite comprehensive treatment strategies encompassing surgery, radiation therapy, and chemotherapy, which can notably enhance long-term survival rates among...
Lactate-associated transcriptomic alterations and malignant phenotypes in colorectal cancer [0.03%]
乳酸相关的转录组改变和结直肠癌恶性表型的关系研究
Shujuan Li,Shiwei Feng,Xuanna Li et al.
Shujuan Li et al.
Lactate, an energy source and metabolic by-product, has been implicated in cancer progression, but its role in colorectal cancer (CRC) remains incompletely understood. This study investigated the clinical significance, biological effects, a...
A tumor microenvironment-focused signature based on m6A and lactylation modification predicts prognosis and immunotherapy response in hepatocellular carcinoma [0.03%]
基于m6A和乳酰化修饰的肿瘤微环境聚焦型标志物可预测肝细胞癌预后及免疫治疗响应能力
Shaohui Zhang,Jianhua Liu,Jun Guan et al.
Shaohui Zhang et al.
This study aims to investigate the role of lactylation and m6A modification-related genes in the tumor microenvironment and immunotherapy for hepatocellular carcinoma (HCC) patients. RNA-sequence data and corresponding clinical information ...
Barriers to fertility preservation among cancer patients in the Middle East and North Africa (MENA) region: a scoping review [0.03%]
中东和北非地区癌症患者生育力保存的障碍：一项综述研究
Gerald Amandu Matua,Eilean Rathinasamy Lazarus,Joshua Kanaabi Muliira et al.
Gerald Amandu Matua et al.
Introduction: Advances in cancer care have increased survival and demand for quality cancer survivorship care. Among survivors of reproductive age, the sequelae of gonadotoxic cancer treatments such as infertility present...
Mechanistic investigation of artesunate against head and neck squamous cell carcinoma through network pharmacology and experimental validation [0.03%]
网络药理学和实验验证指导的青蒿琥酯对头颈鳞癌的作用及机制研究
Lei Wei,Dan He,LiFeng Jia et al.
Lei Wei et al.
Background: Artesunate (ART), a semisynthetic derivative of artemisinin, has demonstrated antitumor activity in multiple malignancies; however, its cytotoxic activity and underlying mechanisms in head and neck squamous ce...
Liu Sumei,Forouzan Bahmani
Liu Sumei
The immunological synapse, a highly organized cell-cell junction, is an important fulcrum for effective T-cell-mediated killing of cancer cells. In multiple myeloma, however, therapeutic resistance reflects multiple interacting layers, incl...
Cuproptosis as a novel predictor of immunotherapy response and shapes the immune landscape in pan-cancer analysis [0.03%]
铜死亡作为预测免疫治疗反应的新标志物并重塑泛癌免疫图谱
Yitong Pan,Xiaodi Hu,Jun Cheng
Yitong Pan
The heterogeneity of cancer renders its response to immunotherapy elusive, warranting the identification of robust biomarkers for evaluation. As a form of recently defined regulated cell death (RCD), cuproptosis is driven by copper-dependen...
Pembrolizumab induced life threatening adrenal crisis in a patient with recurrent adrenocortical carcinoma after unilateral adrenalectomy [0.03%]
帕博利珠单抗致一侧肾上腺切除后复发性肾上腺皮质癌患者生命垂危的肾上腺危象
Benmo Xu,Chengbin Lu,Sinan Yang et al.
Benmo Xu et al.
A 58-year-old female patient with recurrent left adrenal cortical carcinoma following surgery developed severe nausea, vomiting, anorexia, and hypovolemic shock, accompanied by profound hyponatremia, approximately 2 weeks after receiving pe...
The role of the miR-200a-5p/NFIA axis in the progression and clinical prognosis of non-small cell lung cancer [0.03%]
miR-200a-5p/NFIA轴在非小细胞肺癌进展和临床预后中的作用
Xu Wang,Mingli Zhao,Jinping Li et al.
Xu Wang et al.
Purpose: Non-small cell lung cancer (NSCLC) is characterized by a remarkably high mortality rate in clinical settings. This study aims to explore the mechanism of the miR-200a-5p/NFIA (nuclear factor I/A) axis in NSCLC an...