Bibliometric insights into the advancements and future directions of hypofractionated radiotherapy in breast cancer [0.03%]
文献计量揭示的乳腺癌低分割放射治疗的进展与未来方向
Wenping Ding,Shuo Liu,Huili Wang et al.
Wenping Ding et al.
Background: Radiotherapy is essential after breast cancer surgery to prevent local recurrence. However, conventional fractionation involves extended treatment courses that can strain healthcare resources. In recent years,...
The functional roles and therapeutic potential of protein palmitoylation in hepatocellular carcinoma [0.03%]
蛋白质棕榈酰化在肝细胞癌中的功能作用和治疗潜力
Fang Wei,Zi Qing Zhu,Yu Meng et al.
Fang Wei et al.
Objective: Protein palmitoylation is a reversible lipid post-translational modification that influences protein stability, membrane association, and signal transduction. Increasing evidence indicates that dysregulated pal...
Case report of adult-type diffuse high-grade glioma IDH-wildtype subtype E with secondary spinal leptomeningeal dissemination, prolonged survival and literature review [0.03%]
成人弥漫性高级别胶质瘤IDH野生型亚型E继发脊髓脑膜转移1例报告并文献复习
Adèle Meola,Romain Appay,Benoit Testud et al.
Adèle Meola et al.
Objectives: We report the case of an adult-type diffuse glioma with spinal leptomeningeal dissemination, corresponding to a new molecularly methylation class, identified as "Adult-type diffuse high-grade glioma, IDH-wildt...
SMARCA4 mutations drive metastatic progression and predict poor survival in breast cancer based on a real-world cohort study [0.03%]
基于真实世界队列研究的SMARCA4基因突变驱动乳腺癌转移进展及预示不良生存结果
Yanfang Yang,Yaoyang Guo,Mingyu Zhu et al.
Yanfang Yang et al.
To investigate the incidence, clinicopathological characteristics, and prognostic impact of SMARCA4 mutations in breast cancer, we conducted a retrospective cohort study using the MSK-CHORD database, enrolling 4,032 patients categorized int...
Long-term risk of second primary malignancy in young women with breast cancer receiving postoperative radiotherapy [0.03%]
接受术后放射治疗的年轻乳腺癌女性患继发性恶性肿瘤长期风险较高
Jingna Wu,Bo Gao,Yunuo Zhang
Jingna Wu
Background: Therapy for young women with breast cancer (YWBC) in early stage includes surgery, radiotherapy, and endocrinotherapy. Radiation exposure, including from postoperative radiotherapy (PORT), is known to increase...
Construction of a prognostic prediction model for diffuse large B-cell lymphoma patients based on ferroptosis-related LncRNAs [0.03%]
基于铁死亡相关LncRNA的DLBCL患者预后预测模型构建
Yirong Wang,Pengcheng Feng
Yirong Wang
Objective: To investigate the prognostic value of a model based on ferroptosis-related long non-coding RNAs (lncRNAs) for patients with diffuse large B-cell lymphoma (DLBCL). ...
CDK9 inhibitor A09-003 overcomes TRAIL resistance via dual Mcl-1 suppression in breast cancer cells [0.03%]
CDK9抑制剂A09-003通过在乳腺癌细胞中双重抑制Mcl-1克服TRAIL耐药性
Kyoung Mi Sim,Supyong Hwang,Sojung Park et al.
Kyoung Mi Sim et al.
Background: Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a main limitation in breast cancer therapy. Identifying effective sensitizers is crucial to overcome this hurdle. Cyclin-depende...
Molecular mechanisms and clinical impacts of sex differences in urologic cancers [0.03%]
泌尿系统癌症中性别差异的分子机制和临床影响
Pengcheng Fu,Dong Wen,Geliu Shuai et al.
Pengcheng Fu et al.
Urological cancers exhibit significant sex differences in incidence, treatment response, and prognosis, with males generally showing higher morbidity and mortality. This review systematically summarizes the underlying molecular and clinical...
A lipid nanoparticle-based peptide-proteolysis-targeting chimera degrades BCL6 for diffuse large B-cell lymphoma treatment [0.03%]
一种基于脂质纳米颗粒的肽蛋白水解靶向嵌合体降解BCL6以治疗弥漫性大B细胞淋巴瘤
Shiwei Liu,Xueying Gao,Xuan Ye et al.
Shiwei Liu et al.
B-cell lymphoma 6 (BCL6) is an attractive drug target for diffuse large B-cell lymphoma (DLBCL). This study aimed to create a lipid nanoparticle (LNP)-based peptide-proteolysis-targeting chimera (PROTAC), specifically BCL6-PROTAC, to develo...
Deciphering the potential pathogenic mechanisms of 3-BHA in ovarian cancer through integrated bioinformatics and machine learning strategies [0.03%]
基于整合生物信息学和机器学习策略解码3-BHA在卵巢癌中的潜在致病机制
Yifei Shi,Dong Niu,Chunhui Jin
Yifei Shi
Ovarian cancer (OC) remains a malignancy characterized by obscure risk factors and unfavorable prognosis. While 3-tert-butyl-4-hydroxyanisole (3-BHA) is suspected of exerting toxic effects on ovarian health, the precise molecular mechanisms...