Revealing the promising therapeutic targets and prognostic markers of primary mediastinal large B-cell lymphoma [0.03%]
揭示原发性纵隔大B细胞淋巴瘤的治疗靶点及预后标志物
Yuge Liu,Shuai Li,Chen Zhang et al.
Yuge Liu et al.
Primary mediastinal large B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma, which has been considered to be a separate subtype different from diffuse large B-cell lymphoma (DLBCL). PMBCL has unique molecular signatures characterized...
Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort [0.03%]
埃及队列中HLA-I和-II等位基因与丙型肝炎相关性肝病进展之间的关联映射
Mai M Lotfy,Noura A A Ebrahim,Mohamed El-Kassas et al.
Mai M Lotfy et al.
Background and aim: Host genetic factors, particularly human leukocyte antigen (HLA) polymorphisms, play a crucial role in determining the immunological outcome of Hepatitis C virus (HCV) infection. These genetic variatio...
Chuanbao Zhang,Runping Hou,Yangyang Wang et al.
Chuanbao Zhang et al.
Background: Lung adenocarcinoma brain metastasis (LUAD-BM) is a leading cause of cancer-related mortality, yet the genomic determinants driving brain tropism and reliable predictive biomarkers remain poorly defined. ...
Multidimensional immune ecological subtyping identifies RUNX1 as a prognostic factor in uveal melanoma [0.03%]
多维免疫生态分型识别RUNX1作为眼脉络膜黑色素瘤的预后因素
Wen-Qing Yan,Yan Li,Xiao-Yi Qin et al.
Wen-Qing Yan et al.
Uveal melanoma (UVM) is an aggressive intraocular malignancy with a high risk of metastasis but few effective therapies. However, current molecular classification systems do not completely reflect the immune-stromal interactions underlying ...
The global clinical trial landscape of lung cancer cellular therapy current status trends and scientific challenges [0.03%]
全球肺癌细胞疗法临床试验格局现状、趋势和科学挑战
Chang Song,Dong-Sheng Lu,Chun-Yan Zhao et al.
Chang Song et al.
Objective: This study aims to review the development trends of clinical trials for lung cancer cellular therapy systematically, analyze the spatiotemporal distribution, research entities, cell types, target selection quan...
Protein expression profiling of lenvatinib-resistant liver cancer cells and identify B4GALT4 as a critical drug resistance molecule [0.03%]
仑伐替尼耐药肝癌细胞的蛋白质表达谱分析及鉴定关键耐药分子B4GALT4
Xueqin Wu,Yinglian Pan,Jianghan Pu et al.
Xueqin Wu et al.
Lenvatinib is the primary targeted drug for hepatocellular carcinoma(HCC). However, the development of drug resistance significantly hinders its therapeutic efficacy. The present study aimed to identify new target molecules of lenvatinib-re...
Exosomal circVANGL1 promotes cisplatin resistance in osteosarcoma cells by regulating the miR-145-5p/E2F3 axis [0.03%]
外泌体circVANGL1通过调节miR-145-5p/E2F3轴促进骨肉瘤细胞顺铂耐药性
Fan Mo,Hao Wang,Qi Xie et al.
Fan Mo et al.
Background and objectives: Osteosarcoma (OS) is a malignant bone tumor originating directly from bone tissue, predominantly affecting adolescents. Cisplatin (DDP)-based chemotherapy is commonly used in the treatment of OS...
Correction: Mitochondrial-mediated apoptosis as a therapeutic target for FNC (2'-deoxy-2'-b-fluoro-4'-azidocytidine)-induced inhibition of Dalton's lymphoma growth and proliferation [0.03%]
校正：线粒体介导的细胞凋亡作为FNC（2'-脱氧-2'-b-氟-4'-叠氮胞苷）诱导Dalton淋巴瘤生长和增殖抑制的治疗靶点
Naveen Kumar,Sanjeev Kumar,Alok Shukla et al.
Naveen Kumar et al.
Published Erratum
Discover oncology. 2026 May 6;17(1):704. DOI:10.1007/s12672-026-05021-0 2026
Kehong Wei,Qing Gao,Chaoliang Xu et al.
Kehong Wei et al.
Background: Brain metastasis from colorectal cancer (CRC) remains a highly lethal disease. However, the molecular mechanisms driving CRC brain metastasis are not fully characterized. ...
Systematic analyses to explore kinase gene set-based signature in glioma, in which WEE1 contributes to tumor progression [0.03%]
系统分析胶质瘤中的激酶基因组特征，WEE1促进肿瘤进展
Duanni Zhang,Xiaodong Li,Ping Mao et al.
Duanni Zhang et al.
Objectives: Despite the close association with patient clinical outcomes, dysregulated kinases in gliomas are not commonly used as clinical indicators. We aimed to identify a kinase-related gene signature for glioma patie...