Expression of PIEZO1 in lung adenocarcinoma correlates with PD-L1 expression, cell migration, and poor prognosis: an exploratory study [0.03%]
PIEZO1在肺腺癌中的表达与PD-L1表达、细胞迁移及不良预后相关：一项探索性研究
Hongyan Xu,Pengcheng Zou,Yang Gao et al.
Hongyan Xu et al.
Background and aims: Lung adenocarcinoma (LUAD) treatment is challenging process. and the function of PIEZO1, a mechanically sensitive ion channel has not been systematically determined. In this study we aimed to explore ...
Prevalence and pattern of cancers among patients attending Al-Hayat Hospital in Boorama, Somaliland [0.03%]
索马里兰布尔马阿赫亚特医院就诊患者的癌症流行病学和模式研究
Abdirashid S Yusuf,Abdihakim Mohamed H Ali
Abdirashid S Yusuf
Background: Cancer is a growing public health concern in developing nations, yet data from many regions, including Somaliland, remains scarce. The absence of population-based cancer registries means that hospital-based st...
Bioinformatic analysis reveals the potential association of ESRP1 with the splicing of cytoskeleton-associated genes in doxorubicin-resistant MCF7 breast cancer cells [0.03%]
生物信息学分析揭示ESRP1可能与阿霉素耐药MCF7乳腺癌细胞骨架相关基因的可变剪接有关
Jing Zhang,Libin Chen,Qingling Song et al.
Jing Zhang et al.
Background: Breast cancer remains one of the most prevalent malignancies among women, with doxorubicin resistance posing a significant challenge that undermines treatment success and survival outcomes. Aberrant alternativ...
Cancer-associated fibroblasts as a target in head and neck squamous cell carcinoma: bridging mechanisms to therapy with drugs, adjuvants, and nanotechnology [0.03%]
癌症相关成纤维细胞作为头颈鳞癌治疗靶点：从机制到药物、辅助疗法及纳米技术治疗
Mohammed Asiri,Hazem Zabebaha,Uday Abdul-Reda Hussein et al.
Mohammed Asiri et al.
The tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous cellular landscape in which cancer cells, stromal cells, immune cells, and their secreted mediators collectively sustain a dynamic e...
Pan-cancer integrative profiling of immune-related lncRNAs unveils tumor microenvironment subtypes and prognostic biomarkers [0.03%]
泛癌免疫相关长链非编码RNA的综合分析揭示了肿瘤微环境亚型和预后生物标志物
Yun Wang,Guohua Zhu
Yun Wang
Background: Long non-coding RNAs (lncRNAs) have been widely implicated in modulating immune pathway activity and immune cell infiltration to influence cancer outcomes. However, only a few immune-related lncRNAs have been ...
Evaluating the value of neoadjuvant radiotherapy in patients with breast cancer [0.03%]
评估新辅助放疗在乳腺癌患者中的价值
Wenyan Dong,Yao Pan,Zhenglong Wu et al.
Wenyan Dong et al.
Background: The benefits of preoperative neoadjuvant radiotherapy (NART) for breast cancer are not conclusive and there are no well-established guidelines for NART. We aimed to analyze the difference in survival benefit b...
A novel model for assessing lymph node metastasis and the immune microenvironment in breast cancer by integrating digital pathology images and transcriptomics [0.03%]
一种新颖的模型：通过整合数字病理图像和转录组学评估乳腺癌淋巴结转移和免疫微环境
Yongliang Sha,Huijie Zhuang,Yiqiu Wang et al.
Yongliang Sha et al.
Background/aims: Accurate prediction of the lymph node status is essential for clinical decision-making in breast cancer. This work aimed to develop a multimodal deep learning model that integrates gene expression data wi...
Development and validation of a four-gene prognostic signature derived from disulfidptosis- and cuproptosis-related genes in oral squamous cell carcinoma [0.03%]
基于二硫化依赖性和铜死亡依赖性基因的口腔鳞状细胞癌预后标志物的开发与验证
Yao Yao,Xiaoshan Li,Ziyan Pang et al.
Yao Yao et al.
Background: Disulfidptosis and cuproptosis are recently identified forms of regulated cell death whose component genes may harbor prognostic information in oral squamous cell carcinoma (OSCC). However, no validated multi-...
Antitumor effect of dipyridamole mediated by inhibiting the interaction between platelets and tumor cells [0.03%]
二氢吡啶醇通过抑制血小板与肿瘤细胞相互作用的抗肿瘤效果
Jie Xue,Jianzhao Deng,Hongwei Qin et al.
Jie Xue et al.
Dipyridamole is a well-known antithrombotic and a vasodilator. It is used to treat cerebrovascular and cardiovascular diseases owing to its antiplatelet effects. Platelets play a key role in thrombosis and hemostasis, and after cancer cells...
Basement membrane related genes in lung adenocarcinoma prognostic risk model based on single cell and bulk RNA sequencing and tumor microenvironment modulation [0.03%]
基于单细胞和批量RNA测序的肺腺癌基底膜相关基因预后风险模型及肿瘤微环境调控作用研究
Jianan Yang,Liang Wu,Hongjuan Gong et al.
Jianan Yang et al.
Background: The heterogeneity of lung adenocarcinoma (LUAD) makes it challenging to fully comprehend its development. Basement Membrane (BM) promotes cell polarity and has a function in cell development. ...