Chunmiao Luo,Fuxing Qin,Dunwei Yao et al.
Chunmiao Luo et al.
Background: Kinesin family member 23 (KIF23) is a microtubule-dependent motor protein essential for cytokinesis, organelle transport, and signaling pathway regulation. Its dysregulation contributes to both tumorigenesis a...
PSMB1 screened by CRISPR-CAS9 promoted breast cancer progression via PI3K-AKT-mTOR signaling [0.03%]
Lu-Wen Chen,Jing Ning,Yong-Qiang Ye et al.
Lu-Wen Chen et al.
Background: Breast cancer is a threat to women's health worldwide. Recent studies have focused on the role of differentially expressed genes in tumors. PSMB1 has been reported to play an important role in tumors, however,...
A prognostic exosome-related mRNAs risk signature correlates with the immune microenvironment in breast cancer [0.03%]
Duntao Su,Bida Peng,Wei Peng et al.
Duntao Su et al.
Background: Breast cancer (BC) represents one of the most prevalent malignancies among women worldwide. Despite substantial advances in diagnostic and therapeutic modalities and pharmacological interventions in recent yea...
Integrated single-cell and bulk RNA-seq analysis reveals an NK-cell-related immune landscape and a prognostic signature for hepatocellular carcinoma [0.03%]
Yanxia He,Zhumei Luo
Yanxia He
Background: Hepatocellular carcinoma (HCC) is characterized by high heterogeneity and poor prognosis. Despite the importance of natural killer (NK) cells in innate immunity, their role in the HCC microenvironment remains ...
Andrea Martina Guida,Luigi Eduardo Conte,Antonella Paone et al.
Andrea Martina Guida et al.
Iatrogenic rectovaginal fistula (RVF) following total mesorectal excision for rectal cancer is an uncommon but profoundly disabling complication, imposing major physical, functional, sexual, and psychosocial burdens. Its pathogenesis is mul...
Identification of MARCKSL1 as an independent prognostic biomarker and analysis of its potential regulatory network in hepatocellular carcinoma [0.03%]
Hui Li,Wentao Zhang,Jiawen Zhao et al.
Hui Li et al.
Hepatocellular carcinoma (HCC) represents a major contributor to cancer-associated mortality globally. Due to the frequently asymptomatic early course and high proportion of late-stage detection, patient outcomes remain unsatisfactory, unde...
Translational prioritization of strategies to overcome poly ADP-ribose polymerase inhibitor resistance in breast cancer based on systematic review of preclinical evidence [0.03%]
Kezhen Shen,Lei Cai
Kezhen Shen
Background: Resistance to poly ADP-ribose polymerase (PARP) inhibitors has emerged as a major obstacle to durable clinical benefit in breast cancer. While multiple preclinical strategies have been proposed, there is a lac...
Exosome-mediated post-transcriptional oncogene regulation as a novel cancer therapeutic strategy [0.03%]
Bunty Sharma,Kawaljit Singh Kaura,Ranjay Kumar Choudhary et al.
Bunty Sharma et al.
Exosomes are tiny vesicles (30-150 nm in size) secreted by nearly every cell type that have lately emerged as essential regulators of intercellular communication and gene expression in cancer. They accommodate bioactive cargos such as miRNA...
Yi Huang,Zhicheng Tang,He Xu et al.
Yi Huang et al.
Background: Drug resistance in renal cell carcinoma (RCC) poses a major challenge to effective treatment. RCC drug resistance is primarily driven by genetic mutations, angiogenesis, immune suppression, metabolic reprogram...
Seolah Lee
Seolah Lee
Purpose: This report expands the known clinical phenotype of anti-Ri (ANNA-2)-associated paraneoplastic syndrome to include isolated neocortical involvement. ...