Reduced Usage of GLS Intronic Polyadenylation Promotes Cellular Senescence [0.03%]
GLS内含子多腺苷酸化使用量的减少会促进细胞衰老
Xueping Li,Yuxin Li,Dong Ding et al.
Xueping Li et al.
Alternative polyadenylation (APA) of mRNA is a widespread transcriptomic mechanism which fine-tunes gene expression and plays important roles in diverse biological processes. Of the different APA types, intronic polyadenylation is a prevale...
Ratiometric core/shell Nanosensors for Simultaneously Measuring Mitochondrial ATP Production and Oxygen Consumption in Living Cells [0.03%]
用于活细胞中同时测量线粒体ATP生成和耗氧的比率型核壳纳米传感器
Rui Jiang,Ying Lian,Enlai Yang et al.
Rui Jiang et al.
A ratiometric dual nanosensor for simultaneously measuring intracellular ATP and oxygen concentration was developed. The nanosensor had a unique core/shell nanostructure, and the hydrophobic oxygen sensitive probe and reference dye are phys...
Xinling Li,Kaili Xie,Qiaoli Wang et al.
Xinling Li et al.
Integrins mediate cell adhesion and transmit cellular chemical and mechanical signals bidirectionally. Abnormal activation of integrin signals drives tumor initiation, invasion, metastasis, and therapeutic resistance. Therefore, integrins a...
Zhonghua Qi,Peng Qi,Xiansen Jiang et al.
Zhonghua Qi et al.
Pancreatic cancer is a highly invasive and heterogeneous malignancy, with its incidence witnessed a global escalation in recent years. This tumor type is typically asymptomatic in its early stages, and the anatomical location of the pancrea...
Insights into Causal Associations of Lipid Traits and Lipid-modifying Drug Targets with Uric Acid and Risk of Gout [0.03%]
脂质特征和降脂药物靶点与尿酸和痛风风险的因果关联的见解
Chenfeng Zou,Bei Yang,Jiaying Zhang et al.
Chenfeng Zou et al.
Emerging lipid-modifying agents show potential but lack evidence for the management of uric acid and gout. We aimed to explore the causal effects of lipid traits, lipid-modifying drugs on uric acid levels and risk of gout. Two-sample MR ana...
Lipoprotein Subfractions Predict All-cause and Cardiovascular Mortality in CKD Patients Undergoing Hemodialysis: A Prospective Cohort Study Based on NMR Metabolomics [0.03%]
基于核磁共振代谢组学的前瞻性队列研究：脂蛋白亚组分预测透析CKD患者的全因死亡和心血管死亡
Qingxia Huang,Han Zhang,Ziyan Shen et al.
Qingxia Huang et al.
Lipoprotein metabolism is markedly altered in chronic kidney disease (CKD). Studies on the association between nuclear magnetic resonance (NMR) derived lipoprotein subfraction signature and mortality in CKD patients undergoing hemodialysis ...
Meiling Chu,Yan Zhang,Jie Chen et al.
Meiling Chu et al.
The impact of lipid metabolism on the development and prognosis of bone metastasis from breast cancer (BRCA) is currently unknown. Sequencing data of BRCA samples in this study were obtained from the University of California, Santa Cruz (UC...
Nuclear Magnetic Resonance-Based Metabolomics Reveals Systemic Metabolic Disarray in the Transition from Acute Kidney Injury To Chronic Kidney Disease [0.03%]
基于核磁共振代谢组学的系统代谢研究揭示急性肾损伤转慢性肾病的代谢紊乱机制
Lingxiao Wang,Xiuru Wang,Tingxiao Zou et al.
Lingxiao Wang et al.
Regulatory Mechanisms of Gut Homeostasis and Bone Metabolism Interplay in Osteoporosis [0.03%]
肠道稳态和骨代谢在骨质疏松症中的调控机制相互作用
Peng Qi,Xin Chen,Hao Liu et al.
Peng Qi et al.
Osteoporosis, a prevalent metabolic bone disorder characterized by reduced bone mass and compromised bone strength, poses a substantial socioeconomic burden worldwide due to its staggering global incidence. Individuals afflicted with osteop...