Large-scale Searching for Causal Relationships of Body Mass Index Bridged Modifiable Lifestyle Factors on Colorectal Cancer Risk: A phenome-Wide Mendelian Randomization Study [0.03%]
基于表型的孟德尔随机化研究：大规模搜索身体质量指数介导的可改变的生活方式因素与结直肠癌风险之间的因果关系
Ming Shao,Wei Wang,Huiqin Li et al.
Ming Shao et al.
Currently, mendelian randomization (MR) has played an important role in studying causality. However, due to the unique role of third-party variables, false positive conclusions may arise in the process of causal inference. We aimed to asses...
Inulin-Type Hexasaccharide Improves Vascular Dementia by Modulating Sphingomyelin Lipid Metabolism [0.03%]
半乳糖碳水化合物改善血管性痴呆中鞘氨醇脂质代谢作用机制研究
Jiayao Liu,Jinghuan Wang,Jialin Zhao et al.
Jiayao Liu et al.
Vascular dementia (VaD) is the second most common type of dementia lacking effective treatments. Inulin-type hexasaccharide (IHS) extracted from traditional Chinese herbal medicine BaJiTian (Morinda officinalis) has antidepressant effects i...
Plasma MicroRNA and Protein Signature Associated with Obesity in the Chinese Han Population Using MicroRNA Omics and Proteomics Analysis of 1026 Subjects [0.03%]
汉族人肥胖相关血浆microRNA和蛋白质标志物的筛选及验证研究
Yun-Xia Xie,Jian-Ge Qiu,Zhao-Hui Yang et al.
Yun-Xia Xie et al.
Overweight and obesity have become major health risks around the world. The risk factors and mechanisms for overweight and obesity are not fullyunderstood. It is critical to establish reliable factors associated with overweight and obesity....
Human Cardiac Organoids Reveal Anti-Fibrotic Therapeutic Potential of JAK1/2 Inhibition Following Cryogenic Injury [0.03%]
冷冻损伤后人心脏类器官揭示JAK1/2抑制的抗纤维化治疗潜力
Bo Yang,Yiyun Liang,Yulu Chen et al.
Bo Yang et al.
Causal Associations of Red Cell Distribution Width with Rheumatoid Arthritis and Congestive Heart Failure: A Phenome-Wide Mendelian Randomization Study [0.03%]
红细胞分布宽度与类风湿性关节炎和充血性心力衰竭的因果关联：表型广泛的孟德尔随机化研究
Jing Lei,Zhenqiu Liu,Renjia Zhao et al.
Jing Lei et al.
Red cell distribution width (RDW) has been reported to be associated with many diseases, but there is no conclusive evidence for any causal relationship. This study aims to explore to determine the causal effects of high RDW on health with ...
Novel Metabolomic and Adiposity Markers Improve Prediction of Obstructive Sleep Apnea: A Prospective Analysis in the China Human Phenobank [0.03%]
新型代谢组学和肥胖标志物可改善对中国人体表型库受试者阻塞性睡眠呼吸暂停预测的能力：前瞻性分析结果
Yudan Wu,Yihan Ba,Chen Chen et al.
Yudan Wu et al.
Identification of High-Performing Blood Metabolite Biomarkers of Lung Cancer in a Chinese Population [0.03%]
在中国人群中鉴定高绩效血液代谢物肺癌生物标志物
Zhenpu Chen,Lun Zhang,Kaining Mao et al.
Zhenpu Chen et al.
Lung cancer is the world's leading cause of cancer deaths. Early detection through low-cost metabolite screening approaches could reduce lung cancer mortality. Here we report the results of a large-scale, quantitative metabolomics study aim...
High-Intensity Sports Participation Induces Itch-Associated Sensitive Skin [0.03%]
高强度体育运动参与诱发敏感性皮肤及瘙痒症状
Yanqing Liu,Fushuo Li,Xinyuan Zhang et al.
Yanqing Liu et al.
Association of Serum Elements and Urinary Arsenic Species with Esophageal Cancer Risk in a Low Metal Exposure Area: A Case-Cohort Study in China [0.03%]
中国低金属暴露地区血清元素和尿砷物种与食管癌风险的病例队列研究
Qingling Su,Zesen Gao,Yan Wu et al.
Qingling Su et al.
The role of multiple elements in esophageal cancer (EC) remains unclear, especially in low-level metal exposure area. To investigate the causal relationship between elements and EC risk, we conducted a case-cohort study nested within the Ta...
Protein Neddylation Beyond Tumor Cells is a Vital Modulator of Anticancer Immunity [0.03%]
蛋白 neddylation 在肿瘤细胞之外的作用是抗癌免疫的重要调节因子
Mengna Xu,Weixiao Liu,Fan Liu et al.
Mengna Xu et al.
Protein neddylation modification involves transfer of neural precursor cell expressed developmentally downregulated protein 8 (NEDD8), a ubiquitin-like protein, to substrates through a three-step enzymatic cascade mediated by NEDD8-activati...