Beyond Mendelian Inheritance: Genetic Buffering and Phenotype Variability [0.03%]
超越孟德尔遗传性：基因缓冲与表型差异性
Andrea Rossi,Zacharias Kontarakis
Andrea Rossi
Understanding the way genes work amongst individuals and across generations to shape form and function is a common theme for many genetic studies. The recent advances in genetics, genome engineering and DNA sequencing reinforced the notion ...
CYP2C9*3 Increases the Ibuprofen Response of Hemodynamically Significant Patent Ductus Arteriosus in the Infants with Gestational Age of More Than 30 Weeks [0.03%]
CYP2C9*3基因多态性致晚期胎龄婴儿动脉导管未闭重症发生率增加及布洛芬疗效提高的研究
Xiang Chen,Yuxi Chen,Tiantian Xiao et al.
Xiang Chen et al.
Hemodynamically significant patent ductus arteriosus (hsPDA) is a severe condition in newborns. Ibuprofen is an effective treatment to reduce the severe complications and the need for surgical treatment. Several single-nucleotide polymorphi...
A Comprehensive Review of High Throughput Phenotyping and Machine Learning for Plant Stress Phenotyping [0.03%]
植物逆境表型的高通量表型和机器学习综合述评
Taqdeer Gill,Simranveer K Gill,Dinesh K Saini et al.
Taqdeer Gill et al.
During the last decade, there has been rapid adoption of ground and aerial platforms with multiple sensors for phenotyping various biotic and abiotic stresses throughout the developmental stages of the crop plant. High throughput phenotypin...
Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in Drosophila melanogaster [0.03%]
果蝇大脑特异性HDAC6基因敲低引起免疫抑制改善衰老表型
Yingying Zhao,Hongwen Xuan,Chao Shen et al.
Yingying Zhao et al.
HDAC6 is involved in several biological processes related to aging-associated diseases. However, it was unknown whether HDAC6 could directly regulate lifespan and healthspan. We found that HDAC6 knockdown induced transcriptome changes to at...
Recent Progresses in Electrochemical DNA Biosensors for MicroRNA Detection [0.03%]
电化学生物传感器检测微小核糖核酸的研究进展
Lulu Zhang,Wenqiong Su,Shuopeng Liu et al.
Lulu Zhang et al.
MicroRNAs (miRNAs), as the small, non-coding, evolutionary conserved, and post-transcriptional gene regulators of the genome, have been highly associated with various diseases such as cancers, viral infections, and cardiovascular diseases. ...
Systematic Genome-Wide Profiles Reveal Alternative Splicing Landscape and Implications of Splicing Regulator DExD-Box Helicase 21 in Aggressive Progression of Adrenocortical Carcinoma [0.03%]
系统基因组学特征揭示肾上腺皮质癌中剪接调节因子DExD-box螺旋酶21的剪接景观及作用机制
Wenhao Xu,Aihetaimujiang Anwaier,Wangrui Liu et al.
Wenhao Xu et al.
Alternative splicing (AS) in the tumor biological process has provided a novel perspective on carcinogenesis. However, the clinical significance of individual AS patterns of adrenocortical carcinoma (ACC) has been underestimated, and in-dep...
Adjustment for the Age- and Gender-Related Metabolic Changes Improves the Differential Diagnosis of Parkinsonism [0.03%]
校正年龄和性别相关的代谢变化可改善帕金森综合征的鉴别诊断
Jiaying Lu,Min Wang,Ping Wu et al.
Jiaying Lu et al.
Age and gender are the important factors for brain metabolic declines in both normal aging and neurodegeneration, and the confounding effects may influence early and differential diagnosis of neurodegenerative diseases based on the [18F]flu...
Mental Calculation Drives Reliable and Weak Distant Connectivity While Music Listening Induces Dense Local Connectivity [0.03%]
心算强化了远程脑区间连接而听音乐增强了局部脑区间的连接
Gaoxing Zheng,Yuzhu Li,Xiaoying Qi et al.
Gaoxing Zheng et al.
Mathematical calculation usually requires sustained attention to manipulate numbers in the mind, while listening to light music has a relaxing effect on the brain. The differences in the corresponding brain functional network topologies und...
Effect of Light on Cognitive Function During a Stroop Task Using Functional Near-Infrared Spectroscopy [0.03%]
使用功能性近红外光谱仪研究光照对学生stroop任务中认知功能的影响
Yafei Yuan,Guanghao Li,Haoran Ren et al.
Yafei Yuan et al.
Light modulates human brain function through its effect on circadian rhythms, which are related to several human behavioral and physiological processes. Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical neuroimaging tec...
In Situ Saturating Mutagenesis Screening Identifies a Functional Genomic Locus that Regulates Ucp1 Expression [0.03%]
原位饱和诱变筛选鉴定到一个调节UCP1表达的功能基因组区域
Yan Qiu,Xiaojian Liu,Yingmin Sun et al.
Yan Qiu et al.
A better understanding of the molecular mechanisms that control the UCP1 expression in brown and beige adipocytes is essential for us to modulate adipose cell fate and promote thermogenesis, which may provide a therapeutic view for the trea...