Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study [0.03%]
基于基因决定的血铜浓度对多种疾病影响的因果关系：孟德尔随机化和表型组学-wide关联研究
Xiuming Feng,Wenjun Yang,Lulu Huang et al.
Xiuming Feng et al.
Exposures to copper have become a health concern. We aim to explore the broad clinical effects of blood copper concentrations. A total of 376,346 Caucasian subjects were enrolled. We performed a Mendelian randomization and phenome-wide asso...
Global Quantitative Proteomics Analysis Reveals the Downstream Signaling Networks of Msx1 and Msx2 in Myoblast Differentiation [0.03%]
全局定量蛋白质谱分析揭示Myf5和MyoD在肌母细胞分化中的下游信号网络
Guoqiang Zhou,Shuangping Ma,Ming Yang et al.
Guoqiang Zhou et al.
The msh homeobox 1 (Msx1) and msh homeobox 2 (Msx2) coordinate in myoblast differentiation and also contribute to muscle defects if altered during development. Deciphering the downstream signaling networks of Msx1 and Msx2 in myoblast diffe...
Metabolic Molecular Diagnosis of Inflammatory Bowel Disease by Synergistical Promotion of Layered Titania Nanosheets with Graphitized Carbon [0.03%]
协同促进层状二氧化钛纳米片与石墨化碳的合成用于炎症性肠病的代谢分子诊断
Xufang Hu,Yang Zhang,Chunhui Deng et al.
Xufang Hu et al.
Due to inefficient diagnostic methods, inflammatory bowel disease (IBD) normally progresses into severe complications including cancer. Highly efficient extraction and identification of metabolic fingerprints are of significance for disease...
Strided Self-Supervised Low-Dose CT Denoising for Lung Nodule Classification [0.03%]
基于滑动窗口的自监督低剂量CT去噪及肺结节分类方法
Yiming Lei,Junping Zhang,Hongming Shan
Yiming Lei
Lung nodule classification based on low-dose computed tomography (LDCT) images has attracted major attention thanks to the reduced radiation dose and its potential for early diagnosis of lung cancer from LDCT-based lung cancer screening. Ho...
Xiaokai Zhang,Aijun Sun,Junbo Ge
Xiaokai Zhang
Gene polymorphism of acetaldehyde dehydrogenase 2 (ALDH2), a key enzyme for alcohol metabolism in humans, can affect catalytic activity. The ALDH2 Glu504Lys mutant allele has a high-frequency distribution in East Asian populations and has b...
Genetic Architecture of Childhood Kidney and Urological Diseases in China [0.03%]
中国儿童肾脏和泌尿系统疾病的遗传结构
Ye Fang,Hua Shi,Tianchao Xiang et al.
Ye Fang et al.
Kidney disease is manifested in a wide variety of phenotypes, many of which have an important hereditary component. To delineate the genotypic and phenotypic spectrum of pediatric nephropathy, a multicenter registration system is being impl...
Martin Picard
Martin Picard
Modern Western biomedical research and clinical practice are primarily focused on disease. This disease-centric approach has yielded an impressive amount of knowledge around what goes wrong in illness. However, in comparison, researchers an...
Prediction of Metabolic Disorders Using NMR-Based Metabolomics: The Shanghai Changfeng Study [0.03%]
基于核磁共振代谢组学的代谢紊乱预测研究——上海长风队列
Qi Wu,Qing-Xia Huang,Hai-Luan Zeng et al.
Qi Wu et al.
A metabolically healthy status, whether obese or not, is a transient stage with the potential to develop into metabolic disorders during the course of life. We investigated the incidence of metabolic disorders in 1078 metabolically healthy ...
Optical Imaging of Epigenetic Modifications in Cancer: A Systematic Review [0.03%]
癌症表观遗传修饰光学成像的系统性综述研究
Yang Du,Pei Zhang,Wei Liu et al.
Yang Du et al.
Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly related to cancer initiation. Thus, sensitive and specific detection of epigenetic modifications could markedly improve biological investigations and c...
Large-Scale Proteomics Data Reveal Integrated Prognosis-Related Protein Signatures and Role of SMAD4 and RAD50 in Prognosis and Immune Infiltrations of Prostate Cancer Microenvironment [0.03%]
大规模蛋白质组数据揭示了预后相关蛋白标志物的整合作用以及SMAD4和RAD50在前列腺癌微环境预后和免疫浸润中的作用
Aihetaimujiang Anwaier,Shu-Xuan Zhu,Xi Tian et al.
Aihetaimujiang Anwaier et al.
As prostate cancer (PCa) is one of the most commonly diagnosed cancer worldwide, identifying potential prognostic biomarkers is crucial. In this study, the survival information, gene expression, and protein expression data of 344 PCa cases ...