Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis [0.03%]
补体C3、C4与非酒精性脂肪肝疾病之间的因果关系：双向孟德尔随机化分析
Longman Li,Lulu Huang,Aimin Yang et al.
Longman Li et al.
The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship between serum C3 and C4 levels and NAFLD. After exclusion criteria, a total of 1600 Chinese ...
Chinese Medicine Phenomics (Chinmedphenomics): Personalized, Precise and Promising [0.03%]
中医表型组学（ ChinMedPhenomics）：个性化、精准化和前景广阔
Chunchun Yuan,Weiqiang Zhang,Jing Wang et al.
Chunchun Yuan et al.
The systematicness of phenomics and Traditional Chinese Medicine (TCM) enable these two disciplines to interlink with each other. This article discussed the similarity in theory and application between TCM and phenomics and illustrates thei...
Phenotypes of Cardiovascular Diseases: Current Status and Future Perspectives [0.03%]
心血管疾病的表型：现状与未来展望
Hang Zhang,Xiumeng Hua,Jiangping Song
Hang Zhang
Cardiovascular diseases (CVDs) are a large group of diseases and have become the leading cause of morbidity and mortality worldwide. Although considerable progresses have been made in the diagnosis, treatment and prognosis of CVD, communica...
Low Concordance Between Blood Pressures Measured in Periodic Health Examinations and in a Workplace-Based Hypertension Management Program [0.03%]
定期健康检查和基于工作场所的高血压管理计划中测量的血压一致性较低
Jun-Xiang Chen,Yan-Feng Zhou,Tingting Geng et al.
Jun-Xiang Chen et al.
Poor adherence to standard protocols of blood pressure (BP) measurement in routine clinical practice leads to higher readings than "research-quality" measurements. Whether this phenomenon exists in periodic health examinations was unknown. ...
Three Novel Mutations of Microphthalmos Identified in Two Chinese Families [0.03%]
在中国两个家庭中鉴定出三种小眼症的新突变
Yating Tang,Jie Xu,Yi Lu et al.
Yating Tang et al.
Genetic alterations are a major cause of microphthalmos, while novel-related genes and mutations in microphthalmos have rarely been explored. To identify the underlying genetic defect responsible for microphthalmos eyes in two three-generat...
Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes [0.03%]
全表型组关联分析揭示遗传决定的肝酶水平与疾病的新型联系
Zhenqiu Liu,Chen Suo,Yanfeng Jiang et al.
Zhenqiu Liu et al.
Serum liver enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], λ-glutamyl transferase [GGT] and alkaline phosphatase [ALP]) are the leading biomarkers to measure liver injury, and they have been reported to be assoc...
Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction: Evidence from Metabolomics [0.03%]
心射血分数保留型心力衰竭患者中可溶性环氧化物水解酶活性升高与死亡率呈正相关：代谢组学证据
Liyuan Peng,Ziping Song,Chengcheng Zhao et al.
Liyuan Peng et al.
Epoxyeicosatrienoic acids (EETs) have pleiotropic endogenous cardiovascular protective effects and can be hydrolyzed to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH). Heart failure with preserved ejectio...
Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem [0.03%]
从皮肤生态系统角度审视的皮肤微生态、代谢组与表型组
Huizhen Chen,Qi Zhao,Qian Zhong et al.
Huizhen Chen et al.
Skin is a complex ecosystem colonized by millions of microorganisms, including bacteria, fungi, and viruses. Skin microbiota is believed to exert critical functions in maintaining host skin health. Profiling the structure of skin microbial ...
Comparison of Metabolic Profiling of Arabidopsis Inflorescences Between Landsberg erecta and Columbia, and Meiosis-Defective Mutants by 1H-NMR Spectroscopy [0.03%]
采用核磁共振波谱法比较陆地栅状体和哥伦比亚野生型及减数分裂缺陷突变体中拟南芥花序的代谢轮廓差异
Xiang Li,Hongkuan Wang,Ying Wang et al.
Xiang Li et al.
With the rapid development of omics technologies during the last several decades, genomics, transcriptomics, and proteomics have been extensively used to characterize gene or protein functions in many organisms at the cell or tissue level. ...
Random Penetrance of Mutations Among Individuals: A New Type of Genetic Drift in Molecular Evolution [0.03%]
突变随机渗透性：分子进化中的一个新的遗传漂变类型
Xun Gu
Xun Gu
The determinative view of mutation penetrance is a fundamental assumption for the building of molecular evolutionary theory: individuals in the population with the same genotype have the same fitness effect. Since this view has been constan...