Sample Collection, DNA Extraction, and Library Construction Protocols of the Human Microbiome Studies in the International Human Phenome Project [0.03%]
人体微生物组样本收集、DNA提取和文库构建方案——国际人类表型组计划项目子题之三
Yetong Wang,Ruyi Zhang,Yanni Pu et al.
Yetong Wang et al.
The human microbiome plays a crucial role in human health. In the past decade, advances in high-throughput sequencing technologies and analytical software have significantly improved our knowledge of the human microbiome. However, most stud...
High-Resolution and Multidimensional Phenotypes Can Complement Genomics Data to Diagnose Diseases in the Neonatal Population [0.03%]
高分辨率和多维度表型可补充基因组数据以诊断新生儿群体的疾病
Tiantian Xiao,Xinran Dong,Yulan Lu et al.
Tiantian Xiao et al.
Advances in genomic medicine have greatly improved our understanding of human diseases. However, phenome is not well understood. High-resolution and multidimensional phenotypes have shed light on the mechanisms underlying neonatal diseases ...
Identification of Germline Mutations in East-Asian Young Never-Smokers with Lung Adenocarcinoma by Whole-Exome Sequencing [0.03%]
通过对亚洲从不吸烟的年轻肺腺癌患者的全外显子组测序鉴定其胚系突变
Fangqiu Fu,Xiaoting Tao,Zhonglin Jiang et al.
Fangqiu Fu et al.
Recently, an increasing number of young never-smokers are diagnosed with lung cancer. The aim of this study is to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung ad...
In Silico Pipeline to Identify Tumor-Specific Antigens for Cancer Immunotherapy Using Exome Sequencing Data [0.03%]
基于外显子组测序数据的肿瘤特异性抗原鉴定计算流程用于癌症免疫治疗
Diego Morazán-Fernández,Javier Mora,Jose Arturo Molina-Mora
Diego Morazán-Fernández
Tumor-specific antigens or neoantigens are peptides that are expressed only in cancer cells and not in healthy cells. Some of these molecules can induce an immune response, and therefore, their use in immunotherapeutic strategies based on c...
Presence of Rare Variants is Associated with Poorer Survival in Chinese Patients with Amyotrophic Lateral Sclerosis [0.03%]
罕见变异与中国ALS患者生存期缩短有关
Siqi Dong,Xianhong Yin,Kun Wang et al.
Siqi Dong et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with phenotypic and genetic heterogeneity. Recent studies have suggested an oligogenic basis of ALS, in which the co-occurrence of two or more genetic variants has ad...
Autophagic Clearance of Lipid Droplets Alters Metabolic Phenotypes in a Genetic Obesity-Diabetes Mouse Model [0.03%]
自噬溶酶体清除脂滴可改变遗传型肥胖糖尿病小鼠模型的代谢表型
Ningxie Chen,Boxun Lu,Yuhua Fu
Ningxie Chen
Lipid droplets (LDs) are intracellular organelles that store neutral lipids, and their aberrant accumulation is associated with many diseases including metabolic disorders such as obesity and diabetes. Meanwhile, the potential pathological ...
Management of Intraductal Papilloma of the Breast Diagnosed on Core Needle Biopsy: Latest Controversies [0.03%]
乳腺导管内乳头状瘤的诊断与处理（基于空心针活检）最新的争议问题
Siyuan Tu,Yulian Yin,Chunchun Yuan et al.
Siyuan Tu et al.
Intraductal papillomas (IDPs), including central papilloma and peripheral papilloma, are common in the female population. Due to the lack of specific clinical manifestations of IDPs, it is easy to misdiagnose or miss diagnose. The difficult...
Cross-sectional Exploration of the Relationship Between Glutamate Abnormalities and Tic Disorder Severity Using Proton Magnetic Resonance Spectroscopy [0.03%]
利用氢磁共振波谱技术探究谷氨酸异常与抽动障碍严重程度的横断面关系
Juanjuan Hao,Xin Zhang,Ying Liu et al.
Juanjuan Hao et al.
Glutamate (Glu) has been reported to be closely related to the pathophysiology of Tic Disorders (TD). By using proton magnetic resonance spectroscopy (1H-MRS), we aimed to investigate the relationship between in vivo Glu levels and the seve...
Proteomic Portrait of Human Lymphoma Reveals Protein Molecular Fingerprint of Disease Specific Subtypes and Progression [0.03%]
蛋白质组描绘人类淋巴瘤揭示疾病亚型及发展进程的蛋白质分子特征指纹
Xin Ku,Jinghan Wang,Haikuo Li et al.
Xin Ku et al.
An altered proteome in lymph nodes often suggests abnormal signaling pathways that may be associated with diverse lymphatic disorders. Current clinical biomarkers for histological classification of lymphomas have encountered many discrepanc...
Multi-omics Analysis of Young Portulaca oleracea L. Plants' Responses to High NaCl Doses Reveals Insights into Pathways and Genes Responsive to Salinity Stress in this Halophyte Species [0.03%]
多盐分处理下幼年拟南芥蔊菜植物的多组学分析揭示了这种盐生植物应对盐胁迫的途径和基因的见解
Vivianny Nayse Belo Silva,Thalliton Luiz Carvalho da Silva,Thalita Massaro Malheiros Ferreira et al.
Vivianny Nayse Belo Silva et al.
Soil salinity is among the abiotic stressors that threaten agriculture the most, and purslane (Portulaca oleracea L.) is a dicot species adapted to inland salt desert and saline habitats that hyper accumulates salt and has high phytoremedia...