3D Models of Sarcomas: The Next-generation Tool for Personalized Medicine [0.03%]
个性医疗中的下一代工具：肉瘤的三维模型
Ruiling Xu,Ruiqi Chen,Chao Tu et al.
Ruiling Xu et al.
Sarcoma is a complex and heterogeneous cancer that has been difficult to study in vitro. While two-dimensional (2D) cell cultures and mouse models have been the dominant research tools, three-dimensional (3D) culture systems such as organoi...
The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties [0.03%]
超声背向散射测量肌肉骨骼属性的协议
Dongsheng Bi,Lingwei Shi,Boyi Li et al.
Dongsheng Bi et al.
This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic (UBBD) instrument. Dual-energy X-ray absorptiometry (DXA) can be adopted...
Investigating the Immunogenic Cell Death-Dependent Subtypes and Prognostic Signature of Triple-Negative Breast Cancer [0.03%]
探究三阴性乳腺癌的免疫源性细胞死亡依赖亚型和预后标志物
Youyang Shi,Yuanyuan Wu,Feifei Li et al.
Youyang Shi et al.
Recently, immunotherapy has emerged as a promising and effective method for treating triple-negative breast cancer (TNBC). However, challenges still persist. Immunogenic cell death (ICD) is considered a prospective treatment and potential c...
A Heterozygous Phospholamban Variant (p.R14del) Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy [0.03%]
致心律失常性右室心肌病左室受累及心力衰竭表型的一种磷脂酶抑制蛋白杂合变异(p.R14del)
Han Mo,Xiumeng Hua,Mengni Bao et al.
Han Mo et al.
This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) caused by pathogenic mutations in the Phospholamban (PLN) gene. The study included 170 patients who had a confirmed...
Qianzhao Ji,Xiaoyu Jiang,Minxian Wang et al.
Qianzhao Ji et al.
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders. An increasing body of experimental evidence shows that aging is a complex biological process coordinately regula...
Allergic Phenotypes and Sarcopenia: Evidence from Observational Studies and Mendelian Randomization Analysis [0.03%]
基于观察性研究和孟德尔随机化分析的过敏表型与少肌症证据关系研究
Zhenwei Tang,Guowei Zhou,Yi Xiao et al.
Zhenwei Tang et al.
Commonly affected in early-life population, the impact of allergic phenotypes on mid- or late-life health is less discussed. This study is to explore the association of allergic phenotypes including atopic dermatitis (AD), asthma, eosinophi...
Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline: A Community-Based Cohort Study [0.03%]
循环脂蛋白介导心血管风险因素与认知衰退的关系：一项基于社区的研究
Jialin Li,Qingxia Huang,Yingzhe Wang et al.
Jialin Li et al.
Cardiovascular health metrics are now widely recognized as modifiable risk factors for cognitive decline and dementia. Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia. Circulating metabolites ...
Next-Generation Sequencing-Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel DNAH5 Copy Number Variations [0.03%]
基于下一代测序技术的囊性肺纤维化患者CNV分析发现DNAH5新拷贝数变异
Weicheng Chen,Zhuoyao Guo,Mengru Li et al.
Weicheng Chen et al.
Primary ciliary dyskinesia (PCD) is a rare disorder characterized by extensive genetic heterogeneity. However, in the genetic pathogenesis of PCD, copy number variation (CNV) has not received sufficient attention and has rarely been reporte...
Analysis of the Immune Response by Standardized Whole-Blood Stimulation with Metabolism Modulation [0.03%]
代谢调控的标准化全血免疫刺激方法及其免疫反应分析
Jialin Zhao,Xuling Han,Helian Li et al.
Jialin Zhao et al.
The immune system defends the body from infection and plays a vital role in a wide range of health conditions. Metabolism affects a series of physiological processes, including those linked to the function of human immune system. Cellular m...
De Novo Dissecting the Three-Dimensional Facial Morphology of 2379 Han Chinese Individuals [0.03%]
从零开始：解析2379名汉族人的三维面部形态
Hui Qiao,Jingze Tan,Shaoqing Wen et al.
Hui Qiao et al.
Phenotypic diversity, especially that of facial morphology, has not been fully investigated in the Han Chinese, which is the largest ethnic group in the world. In this study, we systematically analyzed a total of 14,838 facial traits repres...