Report on the 4th Board Meeting of the International Human Phenome Consortium [0.03%]
人类表型组国际联盟第四届理事会会议报告
Mei Tian,Han Liu,Shiwen Peng et al.
Mei Tian et al.
Phenome has become a consensus as the next innovation source of biomedicine. As the global network dedicated to large-scale research efforts on human phenome and promoting the Human Phenome Project, the Board of International Human Phenome ...
A Multimodal Approach for Detection and Assessment of Depression Using Text, Audio and Video [0.03%]
一种基于文本、音频和视频的多模态抑郁检测与评估方法
Wei Zhang,Kaining Mao,Jie Chen
Wei Zhang
Depression is one of the most common mental disorders, and rates of depression in individuals increase each year. Traditional diagnostic methods are primarily based on professional judgment, which is prone to individual bias. Therefore, it ...
Quantitative Assessment of Ultraviolet-Induced Erythema and Tanning Responses in the Han Chinese Population [0.03%]
汉族人紫外线诱导发红及晒黑的量化评估研究进展
Yanyun Ma,Yimei Tan,Yue Hu et al.
Yanyun Ma et al.
Ultraviolet radiation (UVR) can induce erythema and tanning responses with strong diversity within and between populations, but there were no precise method for evaluating the variation in these responses. In this study, we assessed the tim...
A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy [0.03%]
基于 phénotype 的行动式精准医学策略在代谢综合征高危人群中的预防干预研究
Qiongrong Huang,Zhiyuan Hu,Qiwen Zheng et al.
Qiongrong Huang et al.
The integration of predictive, preventive, personalized, and participatory (P4) healthcare advocates proactive intervention, including dietary supplements and lifestyle interventions for chronic disease. Personal profiles include deep pheno...
Identification of Poly(ADP-ribose) Polymerase 9 (PARP9) as a Potent Suppressor for Mycobacterium tuberculosis Infection [0.03%]
鉴定出一种针对结核杆菌感染的强力抑制剂多（腺苷二磷酸核糖）聚酶9(PARP9)
Zhenyu Zhu,Shufeng Weng,Fen Zheng et al.
Zhenyu Zhu et al.
ADP-ribosylation is a reversible and dynamic post-translational modification mediated by ADP-ribosyltransferases (ARTs). Poly(ADP-ribose) polymerases (PARPs) are an important family of human ARTs. ADP-ribosylation and PARPs have crucial fun...
The Critical Role of the Shroom Family Proteins in Morphogenesis, Organogenesis and Disease [0.03%]
含Shroom家族蛋白在形态建成、器官发生和疾病中的关键作用
Wanling Liu,Lei Xiu,Mingzhe Zhou et al.
Wanling Liu et al.
The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular localization of Rho-associated kinase (ROCK), which remodels the actomyosin cytoskel...
Bronchoalveolar Lavage Fluid Microbiota is Associated with the Diagnosis and Prognosis Evaluation of Lung Cancer [0.03%]
支气管肺泡灌洗液微生物与肺癌诊断及预后评估相关性研究
Chen Cheng,Zhifeng Wang,Chao Ding et al.
Chen Cheng et al.
The gut microbiota and cancer have been demonstrated to be closely related. However, few studies have explored the bronchoalveolar lavage fluid (BALF) microbiota in patients with lung cancer (LC), specifically the microbiota related to prog...
Linlin Xu,Ting Gan,Pei Chen et al.
Linlin Xu et al.
Genome-wide association studies (GWASs) have identified 30 independent genetic variants associated with IgA nephropathy (IgAN). A genetic risk score (GRS) represents the number of risk alleles carried and thus captures an individual's genet...
Plasma-Free Blood as a Potential Alternative to Whole Blood for Transcriptomic Analysis [0.03%]
无血浆血液作为全血转录组分析的潜在替代品
Qingwang Chen,Xiaorou Guo,Haiyan Wang et al.
Qingwang Chen et al.
RNA sequencing (RNAseq) technology has become increasingly important in precision medicine and clinical diagnostics, and emerged as a powerful tool for identifying protein-coding genes, performing differential gene analysis, and inferring i...
Measurement of Energy Expenditure by Indirect Calorimetry with a Whole-Room Calorimeter [0.03%]
利用整室间接热量计测量能量消耗
Guo Zhou,Kaixuan Bao,Hui Xiao et al.
Guo Zhou et al.
Energy plays a vital role in biological processes. To assess energy metabolism status in a large population cohort, the standard operating procedure for measuring energy expenditure measurement using a whole-room calorimeter was purposed in...