Associations of Plasma Lipidomic Profiles with Uric Acid and Hyperuricemia Risk in Middle-Aged and Elderly Chinese [0.03%]
血浆脂质组学特征与中老年人尿酸和高尿酸风险的关联研究
Wanhui Kang,Xinming Xu,Xiaowei Yang et al.
Wanhui Kang et al.
Little is known about the links of disturbed lipid metabolism with hyperuricemia (HUA). We aimed to investigate the associations of lipidomic profiles with uric acid (UA)/HUA and their modifying factors in middle-aged and elderly Chinese. A...
Living Conditions Alter Ketogenic Diet-induced Metabolic Consequences in Mice through Modulating Gut Microbiota [0.03%]
生活条件通过调节肠道菌群改变生酮饮食诱导的小鼠代谢结局
Jie Yang,Xiao Li,Chen Dai et al.
Jie Yang et al.
Many laboratories have demonstrated that the ketogenic diet (KD) can lead to weight loss and reduced fasting glucose levels, while also increasing total serum cholesterol levels. However, it's worth noting that the specific outcomes induced...
True Ageing: An Up-to-date Model for Evaluating the Immune Age of the Chinese Population [0.03%]
真正的衰老：评估中国人口免疫年龄的最新模型
Hao Cheng,Bin Li
Hao Cheng
The pursuit of immortality has always been a long-standing aspiration of humanity. However, with increasing age comes the unexpected onset of aging. Although time is impartial, the process of ageing lacks uniformity. The human immune system...
A Novel Integrated Pipeline for Site-Specific Quantification of N-glycosylation [0.03%]
一种位点特异性N-糖基化定量的新方法
Yang Zhao,Yong Zhang,Bo Meng et al.
Yang Zhao et al.
The site-specific N-glycosylation changes of human plasma immunoglobulin gamma molecules (IgGs) have been shown to modulate the immune response and could serve as potential biomarkers for the accurate diagnosis of various diseases. However,...
Synergistically Augmenting Cancer Immunotherapy by Physical Manipulation of Pyroptosis Induction [0.03%]
利用物理方法协同增强癌症免疫治疗中的细胞焦亡诱导作用
Chenyang Zhao,Tingting Zheng,Run Wang et al.
Chenyang Zhao et al.
Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammatory responses. Recent studies have elucidated the ...
Jiangxun Ji,Feihong Cai,Chunchun Yuan et al.
Jiangxun Ji et al.
The link between gut microbiota (GM) and primary osteoporosis has garnered substantial attention. In this study, we conducted a systematic review encompassing 10 studies that employed high-throughput sequencing methodologies. Notably, the t...
Expert Consensus on Big Data Collection of Skin and Appendage Disease Phenotypes in Chinese [0.03%]
中国皮肤与附属器疾病表型大数据采集专家共识
Shuang Zhao,Zhongling Luo,Ying Wang et al.
Shuang Zhao et al.
The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormalities. To establish a s...
Identification of Key Factors in Cartilage Tissue During the Progression of Osteoarthritis Using a Non-targeted Metabolomics Strategy [0.03%]
利用非靶向代谢组学策略鉴定软骨组织在骨关节炎进展过程中的关键因素
Shiyu Sun,Minghui Chen,Tingting Zhang et al.
Shiyu Sun et al.
This research was to reveal the key factors in the progression of osteoarthritis (OA) using non-targeted metabolomics and to find targeted therapies for patients with OA. Twenty-two patients with knee OA scheduled for total knee arthroplast...
Kidney Function and Cardiovascular Disease: Evidence from Observational Studies and Mendelian Randomization Analyses [0.03%]
基于观察性研究和孟德尔随机化分析的肾脏功能与心血管疾病的关系
Wenjun Yang,Xuemei Wu,Manying Zhao et al.
Wenjun Yang et al.
Observational studies have identified that declined kidney function was associated with a higher risk of cardiovascular disease (CVD). However, the causation of such associations requires further exploration. Here, we compared the observati...
Investigation on Phenomics of Traditional Chinese Medicine from the Diabetes [0.03%]
基于糖尿病的中医病证表型调查研究
Boxun Zhang,Lijuan Zhou,Keyu Chen et al.
Boxun Zhang et al.
With thousands of years of application history, traditional Chinese medicine (TCM) has unique advantages in the prevention of various chronic diseases, and in recent years, the development of TCM has presented a situation where opportunitie...