Disease Modules Associated with Unfavorable Sleep Patterns and Their Genetic Determinants: A Prospective Cohort Study of the UK Biobank [0.03%]
与不良睡眠模式相关疾病模块及其遗传决定因素的前瞻性队列研究：基于英国生物银行的数据分析
Huazhen Yang,Can Hou,Wenwen Chen et al.
Huazhen Yang et al.
Despite the established associations between sleep-related traits and major diseases, comprehensive assessment on affected disease modules and their genetic determinants is lacking. Using multiple correspondence analysis and the k-means clu...
Prognostic Significance of Methyl-CpG Binding Domain4 Polymorphism rs140693 and Clinical Characteristics in Chinese Lung Cancer Patients [0.03%]
Methyl-CpG结合域4多态性位点rs140693在中国肺癌患者中的预后意义及临床特征分析
Zhengxing Li,Yuewen Hu,Chang Xu et al.
Zhengxing Li et al.
Lung cancer remains the leading cause of death among cancer patients, and the five-year survival rate is less than 25%. However, Methyl-CpG Binding Domain (MBD)4 polymorphism rs140693 predicts the prognosis of lung cancer patients still nee...
Cellular Senescence-Related Long Non-coding RNA Signatures Predict Prognosis in Juvenile Osteosarcoma [0.03%]
与细胞衰老相关的长链非编码RNA特征可预测青少年骨肉瘤的预后
Peng Zhao,Junli Chang,YeKai Chen et al.
Peng Zhao et al.
Osteosarcoma is the most common malignant bone tumor and is frequently diagnosed in juvenile. Cellular senescence is a fundamental hallmark of osteosarcoma and plays a vital role in the initiation and progression of aging and tumorigenesis....
Alterations of Sensory-related Functional Brain Network Connectivity in Nrsn2 Homozygous Knockout Mice [0.03%]
Nrsn2基因纯合子敲除小鼠感觉相关功能脑网络连接的改变
Yuan Yi,Fei Dai,Yuwen Zhang et al.
Yuan Yi et al.
Neurensin-2 (Nrsn2) is a neuro-specific gene linked to neurodevelopmental disorders and has recently been reported to function as a bidirectional emotional regulator, highlighting its molecular roles in the nervous system. However, the conn...
Senescence-Related LncRNAs: Pioneering Indicators for Ovarian Cancer Outcomes [0.03%]
衰老相关长链非编码RNA：卵巢癌预后的开创性指标
Shao-Bei Fan,Xiao-Feng Xie,Wang Wei et al.
Shao-Bei Fan et al.
In gynecological oncology, ovarian cancer (OC) remains the most lethal, highlighting its significance in public health. Our research focused on the role of long non-coding RNA (lncRNA) in OC, particularly senescence-related lncRNAs (SnRlncR...
Site-Specific Quantitative N-Glycoproteomics: The Great Clinical Application Potential of GlycoQuant [0.03%]
位点特异性定量N-糖蛋白组学：GlycoQuant的广阔临床应用前景
Hao Yang,Ganglong Yang,Jicheng Lv et al.
Hao Yang et al.
Cell-Free DNA in Plasma Reveals Genomic Similarity Between Biliary Tract Inflammatory Lesion and Biliary Tract Cancer [0.03%]
血浆游离DNA揭示了胆道炎症病变与胆道癌之间的基因组相似性
Ruimei Liu,Yueqiang Song,Rulin Hua et al.
Ruimei Liu et al.
Similar clinical manifestations and imaging features between biliary tract inflammatory lesion (BTI) and biliary tract cancer (BTC) pose significant challenges for the management of BTC. To date, the molecular characteristics of the relatio...
Risk of Cardiovascular Disease Hospitalization After Common Psychiatric Disorders: Analyses of Disease Susceptibility and Progression Trajectory in the UK Biobank [0.03%]
英国生物银行项目中常见精神障碍后心血管疾病住院风险及其发病易感性和进展轨迹分析
Xin Han,Yu Zeng,Yanan Shang et al.
Xin Han et al.
Whether associations between psychiatric disorders and hospitalization for cardiovascular diseases (CVDs) can be modified by disease susceptibility and the temporal pattern of these associated CVDs remain unknown. In our study, we conducted...
Dissecting the Implications of Calumenin in Malignancy and Heterogeneity of the Microenvironment of Clear Cell Renal Cell Carcinoma Using Multi-Omics Data [0.03%]
利用多组学数据解构钙粘蛋白在透明细胞肾细胞癌恶性度及微环境异质性中的影响及其机制研究
Xin-Qiang Wu,Zhi Shang,Cui Xiong et al.
Xin-Qiang Wu et al.
Increasing evidence indicates that Calumenin (CALU), which is localized in the endoplasmic reticulum, is significantly associated with tumor progression. However, the effect of CALU on patients with clear cell renal cell carcinoma (ccRCC) i...
Modulating and Imaging Macrophage Reprogramming for Cancer Immunotherapy [0.03%]
癌症免疫疗法的巨噬细胞重编程的调控与成像
Jialu Wang,Yafang Lu,Ren Zhang et al.
Jialu Wang et al.
Cancer immunotherapy has made great progress in effectively attacking or eliminating cancer. However, the challenges posed by the low reactivity of some solid tumors still remain. Macrophages, as a key component of the tumor microenvironmen...