IFN-γ Synergizes with TNF-α to Induce RIPK1-Independent Necroptosis of Mesenchymal Stem/Stromal Cells [0.03%]
干扰素γ与肿瘤坏死因子α协同诱导间充质干细胞非受体相互作用蛋白1依赖型坏死性凋亡
Ren Xiang,Huo Jiali,Li Xingxin et al.
Ren Xiang et al.
IFN-γ and TNF-α are two vital inflammatory factors elevated aberrantly in many diseases. Such an inflammatory microenvironment is detrimental to residual cells such as mesenchymal stem cells (MSCs), yet the precise mechanisms are not full...
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses [0.03%]
靶向铁死亡可缓解肺动脉高压 小鼠转录组和实验分析提供新见解
Xiaowan Wang,Qiang Guo
Xiaowan Wang
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling driven by endothelial cell injury. This study investigates the role of ferroptosis in PAH development and its underlying molecular mechanisms. Ferroptos...
Guilongwan Ameliorates Experimental Diabetic Foot Ulcer in Rats via the Inhibition of Delta-Like 4/Notch1 Signaling in M1 Macrophages [0.03%]
归龙丸通过抑制M1型巨噬细胞DLL4/NOTCH1信号通路改善糖尿病足溃疡动物模型的功效学研究
Xi-Ting Lv,Wen-Xiu Yang,Xiao Zhang et al.
Xi-Ting Lv et al.
Guilongwan (GLW), a representative of traditional Chinese Medicine (TCM) has been utilized to treating diabetic foot ulcer (DFU)-related syndrome including an intolerance of cold with cold limbs, blood circulation disorder, and immune dysfu...
Brigitte Städler,Alexander N Zelikin,Julián Valero et al.
Brigitte Städler et al.
Paliperidone Inhibits Ferroptosis Mediated by Autophagy in Renal Tubular Epithelial Cells by Targeting CHAC1 [0.03%]
棕榈酰化蛋白paliperidone通过靶向CHAC1抑制自噬介导的肾小管上皮细胞铁死亡
Xiangrong Ying,Ke Gao,Zhengang Luo et al.
Xiangrong Ying et al.
Renal tubular epithelial cell injury is a significant factor in the formation of kidney stones. However, the regulatory mechanisms behind this injury, especially the association with autophagy-mediated ferroptosis, remain unclear. This stud...
Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration [0.03%]
新型生物活性玻璃纤维促进骨和血管再生
Yuzheng Lu,Yanbo Shan,Yingjie Xiong et al.
Yuzheng Lu et al.
Magnesium phosphate cement (MPC) continues to gain attention in the field of biomedicine. However, its suboptimal mechanical strength and weak biological activity hinder its wider clinical application. Given the excellent biological charact...
PTEN Regulates Myofibroblast Activation in Valvular Interstitial Cells Based on Subcellular Localization [0.03%]
PTEN通过亚细胞定位调控瓣周组织成纤维细胞活化
Dilara Batan,Georgios Tseropoulos,Bruce E Kirkpatrick et al.
Dilara Batan et al.
Aortic valve stenosis (AVS) is characterized by altered mechanics of the valve leaflets, which disrupts blood flow through the aorta and can cause left ventricle hypotrophy. These changes in the valve tissue result in the activation of resi...
Extracellular Vesicles in Aging and Age-Related Diseases. How Important Are They? [0.03%]
细胞外囊泡与衰老及年龄相关疾病的关系：重要性如何？
David J Lundy,Chia-Te Liao
David J Lundy
Extracellular vesicles (EVs), lipid bilayer-bound particles secreted by cells, have attracted significant research attention for their roles in aging-related disorders, including cardiovascular disease, metabolic dysfunction, cancer, and ne...
Xiaoyan Wang,Yuanyuan Xue,Lei Chang et al.
Xiaoyan Wang et al.
Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, has witnessed the continuous discovery of an increasing number of regulatory mechanisms. Trace metal elements play a multifacete...
Edaravone Alleviates BV-2 Microglia-Mediated Neuroinflammation Through the PI3K/AKT/ NF-κB Pathway [0.03%]
依达拉奉通过PI3K/AKT/NF-κB信号通路缓解BV-2微胶质细胞介导的神经炎症
Li Yang,Zhaoda Duan,Dongyao Xu et al.
Li Yang et al.
Ischemic stroke (IS) poses a significant threat to human health. Research has demonstrated that microglia (MG)-mediated neuroinflammatory responses play a crucial role in the pathogenesis of IS. Consequently, inhibiting MG activation and re...