Research Progress on the Combination of PARP Inhibitors (PARPi) and Immune Checkpoint Inhibitors (ICIs) [0.03%]
PARP抑制剂与免疫检查点抑制剂联合治疗的研究进展
Qi Liu,Chunmei Zhang,Yixuan Gao et al.
Qi Liu et al.
Deficiencies in DNA damage repair (DDR), such as poly (ADP-ribose) polymerase (PARP) deficient, cause cancer development by promoting DNA mutations while also exposing the specificity and vulnerability of cancer to afford a treatment option...
Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications [0.03%]
微生理肾小球滤过屏障：当前认知、创新与未来应用
Manon Miran,Kieu Ngo,David Buob et al.
Manon Miran et al.
Chronic kidney disease (CKD) affects over 850 million individuals worldwide, often progressing to stages requiring dialysis or kidney transplants. Central to kidney function is the glomerular filtration barrier (GFB), which selectively filt...
Chaperone-Mediated Autophagy: A Critical Regulator of Neuroinflammation and Neurodegeneration [0.03%]
伴侣介导的自噬：神经炎症和神经退行性病变的关键调节因子
Ying-Ying Han,Xin-Yue Huang,Ying Su et al.
Ying-Ying Han et al.
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by hallmark pathological features such as the accumulation of misfolded proteins and neuroinflammation. Chaperone-mediated autoph...
Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine [0.03%]
GALK剂量在克拉布病酶替代疗法中的细胞效应研究支持纳米医药的作用
Ambra Del Grosso,Sara Carpi,Laura Colagiorgio et al.
Ambra Del Grosso et al.
Krabbe disease (KD) is a lysosomal storage disorder characterized by severe neurodegeneration and demyelination. It is caused by mutations in the galactosylceramidase (GALC) gene, leading to the accumulation of psychosine, a neurotoxic meta...
Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease [0.03%]
针对RAGE的纳米抗体在癌症和阿尔茨海默病分子影像中的应用
Guangfeng Liang,Fujing Wang,Wei Xiong et al.
Guangfeng Liang et al.
The receptor for advanced glycation end products (RAGE) is a multifunctional cell surface receptor implicated in aging and the progression of chronic diseases, including cancer and Alzheimer's disease. Its interaction with advanced glycatio...
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats [0.03%]
粪菌移植通过JAK/STAT信号途径调节ARDS大鼠Th17/Treg平衡
Dongwei Zhang,Biying Dong,Jie Chen et al.
Dongwei Zhang et al.
This study evaluated the therapeutic effects of fecal microbiota transplantation (FMT) on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) in rats. The study focused on the balance of T-helper 17 (Th17) and regula...
Lithocholic Acid, Calorie Restriction, and Halting Aging [0.03%]
鹅膏蕈碱、限制卡路里和抗衰老机制关系的实验研究——胆石酸的发现及其机理
Cade Ward,Michael M Shahid,Grace Hohman et al.
Cade Ward et al.
While aging is a natural biological process, it is associated with a greater risk for multiple diseases, including cancer, neurodegeneration, and cardiovascular disease. Thus, it is important to study the biochemical mechanisms involved in ...
Precision Medicine in ICH Unveiling the Superior Predictive Power of a Joint Model [0.03%]
ICH中的精准医疗：联合模型预测能力的提升
Fa Wu,YuLin Yang,TingTing Wu et al.
Fa Wu et al.
This study examined the effectiveness of a combined model using non-contrast computed tomography (NCCT) imaging, clinical data, and radiomics for predicting early hematoma enlargement in patients with spontaneous intracerebral hemorrhage. T...
Kieran F Reid
Kieran F Reid
Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells [0.03%]
过度吸入氧气诱导人骨髓基质细胞染色质结构的改变
Lauren Monroe,Samantha Kaonis,Natalie Calahan et al.
Lauren Monroe et al.
In eukaryotic cell nuclei, chromatin exhibits a high degree of structural and functional dynamics. Recent findings suggest that chromatin has the ability to reorganize in response to changes within the cellular microenvironment. Such change...