Fibronectin Peptide Modified Hydrogels Activate a Contractile Phenotype in Nucleus Pulposus Cells [0.03%]
纤维连接蛋白肽修饰的水凝胶激活椎间盘髓核细胞的收缩表型
Ananya Naha,John Sorensen,Santiago Lazarte et al.
Ananya Naha et al.
Degenerative disc disease is strongly associated with low back pain, making it a leading cause of disability. With injury and age, cellular remodeling of the disc tissue leads to compositional changes, stiffening, and loss of stress relaxat...
Mirsadeghi Isfahani Paniz,Rastegar Lari Tina,Darbeheshti Farzaneh et al.
Mirsadeghi Isfahani Paniz et al.
Cancer is one of the most pervasive and severe global diseases that cause millions of death annually. Numerous bacterial strains are found to play fundamental roles in tumor formation, growth, and metastasis. On the other hand, specific bac...
Tumor Immune Engineering: Developing In Vitro Assays to Understand the Tumor-Immune Crosstalk [0.03%]
肿瘤免疫工程：开发体外测定方法以了解肿瘤免疫相互作用
Ranjani N Iyer,Maitreyee Vartak,Tuli Dey
Ranjani N Iyer
Interaction between a growing tumor and the host immune system has various facets, which eventually influence the fate of both the tumor and the host. In the last decade, multiple efforts have been undertaken to mimic the heterogeneous cons...
Luteolin Regulates Mitophagy to Alleviate Myocardial Ischemia-Reperfusion Injury via Sirt3/Foxo3a Pathway [0.03%]
通过Sirt3/Foxo3a途径调节线粒体自噬缓解黄酮类化合物山柰酚的心肌缺血再灌注损伤的作用及机制研究
Li Yan,Lei Liang,Qiling Gou et al.
Li Yan et al.
Luteolin (LUT) belongs to a kind of flavonoid, which has protective effects on myocardial ischemia/reperfusion (I/R) injury. Sirt3 is located in mitochondria and interacts with Foxo3a to protect mitochondrial function against stress. Mitoph...
Diana Corallo,Sara Menegazzo,Marcella Pantile et al.
Diana Corallo et al.
Neuroblastoma represents a major challenge in pediatric oncology with over 50% of cases involving metastasis. High-risk patients face an unfavorable prognosis, with survival rates below 40%. LIN28B plays a pivotal role in neuroblastoma deve...
Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment [0.03%]
谷氨酰胺代谢抑制通过重塑巨噬细胞免疫微环境抑制肿瘤进展
Tianhe Li,Sepehr Akhtarkhavari,Sumeng Qi et al.
Tianhe Li et al.
Targeting glutamine metabolism has emerged as a promising strategy in cancer therapy. To attain clinical utility, a number of challenges must be overcome, including in vivo anti-tumor activity, pharmacological toxicity, and clinical safety....
A Pan-Enterovirus Natural Product Inhibitor Targeting a Unique Allosteric Site on the Viral 3C Protease [0.03%]
一种针对病毒3C蛋白酶别构位点的穿肠病毒天然产物抑制剂
Shangwu Sun,Qiang Wang,Mengyao Zhu et al.
Shangwu Sun et al.
Infections caused by Enterovirus like rhinoviruses, coxsackieviruses, and polioviruses represent a significant public health concern, for which there are no antivirals available yet. The highly conserved viral 3C protease has been the prima...
The c-di-GMP Metabolic Gene pdeN Interacts with LacY and ManZ to Modulate Biofilm Formation in Avian Pathogenic Escherichia coli [0.03%]
鸟致病性大肠杆菌中的c-di-GMP代谢基因pdeN通过与LacY和ManZ的相互作用调节生物被膜形成能力
Zhihao Wang,Xiaolong Lv,Lanfang Kong et al.
Zhihao Wang et al.
Bis-(3'-5')-cyclic diguanylic acid (c-di-GMP), a ubiquitous secondary messenger, affects multiple biological characteristics, including biofilm formation in avian pathogenic Escherichia coli (APEC). C-di-GMP is synthesized by diguanylate cy...
Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model [0.03%]
基于间充质基质细胞的动脉粥样硬化斑块帽力学模型：微钙化降低其力学性能
Imke L Jansen,Deniz Şahin,Frank J H Gijsen et al.
Imke L Jansen et al.
Rupture of atherosclerotic plaque caps is the cause of many disabling or lethal cardiovascular events, such as stroke and myocardial infarction. Microcalcifications (
Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno-Free Cultures of Human Adipose Tissue-Derived Stem Cells [0.03%]
福斯克林增强异种培养的人脂肪组织来源干细胞的尿激酶型纤溶酶原激活物分泌和促血管生成作用
Maria Vittoria Giraudo,Anne Therese Lauvrud,Rebecca Wiberg et al.
Maria Vittoria Giraudo et al.
Adipose tissue-derived stem cells (ASCs) hold significant potential for treating various clinical conditions. To enhance their regenerative properties, ASCs can be chemically stimulated using various in vitro protocols. However, unsatisfact...