Microbiome-Mediated Modulation of the Tumour Immune Microenvironment in Oesophageal Squamous Cell Carcinoma [0.03%]
食管鳞状细胞癌中微生物组介导的肿瘤免疫微环境调节作用
Lijing Bai,Anchao Zhu
Lijing Bai
Oesophageal squamous cell carcinoma (ESCC) is the most prevalent type of oesophageal cancer. It is an aggressive malignancy with a poor prognosis, and recent studies have revealed the critical role of the microbiota in its occurrence and de...
3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes [0.03%]
三维乳腺癌体外模型：当前挑战与未来前景——再现微环境和模拟关键过程
Kyndra S Higgins,Ah Joung Yu,Cheryl T Gomillion
Kyndra S Higgins
Each year, ≈1.6 million women are diagnosed with breast cancer worldwide. Of these cases, 0.5 million result in death, with over 90% of these deaths resulting from metastasis. Since it is one of the top 5 cancers with the highest mortality...
Solasonine Restores Sensitivity of Gastric Cancer to NK Cells through DNA Demethylation of MICA [0.03%]
Solasonine通过去甲基化MICA恢复胃癌对NK细胞的敏感性
Tianchuan Li,Ailian Yang,Bingjing He et al.
Tianchuan Li et al.
Solasonine, extracted from Solanum nigrum, has been proven to exert anti-tumor effects in various tumors. However, the role of solasonine in gastric cancer remains unclear. This study aims to elucidate the therapeutic effects of solasonine ...
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? [0.03%]
局部麻醉药与癌症生物学的交集：现状如何？未来何方？
Eduardo Nunez-Rodriguez,Hao Zhang,Dhananjay Sah et al.
Eduardo Nunez-Rodriguez et al.
Local anesthetics (LAs), commonly used for regional and general anesthesia, have gained attention in recent years for their potential role during cancer curative surgery, as they may reduce cancer recurrence and progression. Studies in both...
Adipose Mesenchymal Stem Cell-Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation [0.03%]
脂肪源性间充质干细胞衍生的外泌体联合罗氟司特通过调节纤维化和炎症改善慢性肾脏病
Mohamed Ali,Mohamed H Sherif,Nashwa Barakat et al.
Mohamed Ali et al.
Adipose mesenchymal stem cell-derived exosomes and the PDE4 inhibitor roflumilast (ROF) are investigated as potential treatments for chronic kidney disease (CKD). The exosomes are extracted and analyzed using electron microscopy and flow cy...
Spheroid Cell Aggregation Enhanced by Enzyme-Free Ultrasound-Detached Cells [0.03%]
一种声波解离细胞的无酶球体化方法
Julien van Delft,Chikahiro Imashiro,Yuta Kurashina et al.
Julien van Delft et al.
Spheroids are being widely studied as potential building blocks for complex organ engineering, tools for drug screening and cancer study. However, formation time has become the bottleneck of applications due to the need for large-scale high...
Activation of NF-κB Signaling by Optogenetic Clustering of IKKα and β [0.03%]
光遗传学聚集IKKα和IKKβ激活NF-κB信号通路
Alexandra Anna Maria Fischer,Markus Michael Kramer,Miguel Baños et al.
Alexandra Anna Maria Fischer et al.
Molecular optogenetics allows the control of molecular signaling pathways in response to light. This enables the analysis of the kinetics of signal activation and propagation in a spatially and temporally resolved manner. A key strategy for...
Fibronectin Peptide Modified Hydrogels Activate a Contractile Phenotype in Nucleus Pulposus Cells [0.03%]
纤维连接蛋白肽修饰的水凝胶激活椎间盘髓核细胞的收缩表型
Ananya Naha,John Sorensen,Santiago Lazarte et al.
Ananya Naha et al.
Degenerative disc disease is strongly associated with low back pain, making it a leading cause of disability. With injury and age, cellular remodeling of the disc tissue leads to compositional changes, stiffening, and loss of stress relaxat...
Mirsadeghi Isfahani Paniz,Rastegar Lari Tina,Darbeheshti Farzaneh et al.
Mirsadeghi Isfahani Paniz et al.
Cancer is one of the most pervasive and severe global diseases that cause millions of death annually. Numerous bacterial strains are found to play fundamental roles in tumor formation, growth, and metastasis. On the other hand, specific bac...
Tumor Immune Engineering: Developing In Vitro Assays to Understand the Tumor-Immune Crosstalk [0.03%]
肿瘤免疫工程：开发体外测定方法以了解肿瘤免疫相互作用
Ranjani N Iyer,Maitreyee Vartak,Tuli Dey
Ranjani N Iyer
Interaction between a growing tumor and the host immune system has various facets, which eventually influence the fate of both the tumor and the host. In the last decade, multiple efforts have been undertaken to mimic the heterogeneous cons...