Lithocholic Acid, Calorie Restriction, and Halting Aging [0.03%]
鹅膏蕈碱、限制卡路里和抗衰老机制关系的实验研究——胆石酸的发现及其机理
Cade Ward,Michael M Shahid,Grace Hohman et al.
Cade Ward et al.
While aging is a natural biological process, it is associated with a greater risk for multiple diseases, including cancer, neurodegeneration, and cardiovascular disease. Thus, it is important to study the biochemical mechanisms involved in ...
Precision Medicine in ICH Unveiling the Superior Predictive Power of a Joint Model [0.03%]
ICH中的精准医疗：联合模型预测能力的提升
Fa Wu,YuLin Yang,TingTing Wu et al.
Fa Wu et al.
This study examined the effectiveness of a combined model using non-contrast computed tomography (NCCT) imaging, clinical data, and radiomics for predicting early hematoma enlargement in patients with spontaneous intracerebral hemorrhage. T...
Kieran F Reid
Kieran F Reid
Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells [0.03%]
过度吸入氧气诱导人骨髓基质细胞染色质结构的改变
Lauren Monroe,Samantha Kaonis,Natalie Calahan et al.
Lauren Monroe et al.
In eukaryotic cell nuclei, chromatin exhibits a high degree of structural and functional dynamics. Recent findings suggest that chromatin has the ability to reorganize in response to changes within the cellular microenvironment. Such change...
Oncogenic miR-182-5p Targets NCOA4 to Disrupt the NCOA4-FTH1 Axis-Mediated Ferroptosis in Head and Neck Squamous Cell Carcinoma [0.03%]
miR-182-5p通过靶向NCOA4介导的NCOA4-FTH1轴诱导头颈鳞癌细胞铁死亡的抗肿瘤作用研究
Wulin Wen,Jia Zhao,Wuxia Zhao et al.
Wulin Wen et al.
Head and neck squamous cell carcinoma (HNSCC) is characterized by a high recurrence rate and poor prognosis. Ferroptosis, a regulated cell death, plays a significant role in inhibiting tumor progression. However, its role and regulatory mec...
HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung-Associated Enterocolitis [0.03%]
Hirschsprung病相关性坏死肠炎中来源于吡咯烷的HMGB1促进巨噬细胞胞外陷阱形成
Rui Zhang,Jing Li,Lili Song et al.
Rui Zhang et al.
Hirschsprung-associated enterocolitis (HAEC) is the most common and severe complication in patients with Hirschsprung's disease (HSCR) and is characterized by high morbidity, frequent recurrence and substantial mortality. The formation of m...
Apolipoprotein A-I Binding Protein: Functions, Mechanisms, and Therapeutic Targets in Neurological Disorders [0.03%]
载脂蛋白A-I结合蛋白：在神经疾病中的功能、机制和治疗靶点
Zijian Zhang,Yingjun Wang,Hao Yang et al.
Zijian Zhang et al.
Apolipoprotein A-I binding protein (AIBP) interacts with both apolipoprotein A-I and high-density lipoprotein. It modulates lipid raft-related signaling pathways and affects mitochondrial function, oxidative stress, and inflammatory respons...
Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts - from General Tissue Engineering to Cellular Agriculture [0.03%]
超分子方法工程化模块水凝胶培养原生质体平台——从通用组织工程到细胞农业
Maritza M Rovers,Erik J Slootweg,Ferdinand C O Los et al.
Maritza M Rovers et al.
Protoplast regeneration into plant cells and further into plants is an ongoing challenge in agricultural biotechnology. Inspired by mammalian tissue engineering, a strategic shift is proposed in plant tissue engineering to steer protoplast ...
Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum) [0.03%]
墨西哥钝头螈（Ambystoma_mexicanum）成年后跳跃基因表达上调，肢体再生过程中则被抑制
Samuel Ruiz-Pérez,Nicolás Alcaraz,Karla Torres-Arciga et al.
Samuel Ruiz-Pérez et al.
The axolotl (Ambystoma mexicanum) has a great capacity to regenerate its tissues; however, the fidelity and success of its regenerative process diminish with age. Retrotransposons make up the largest portion of the axolotl genome, and their...
Flow Cytometry and Gene Expression Modulation by Euphorbia rigida Methanol Extract in A549 Lung Cancer Cells: Induction of Apoptosis Through Bax, Caspase-9, and Bcl-2 Pathways [0.03%]
Euphorbia rigida 甲醇提取物对A549肺癌细胞流式分析及基因表达调控作用：通过Bax、Caspase-9和Bcl-2诱导凋亡路径
Zeynep Betül Sarı,Muhammed Emin Sarı,Erdi Can Aytar et al.
Zeynep Betül Sarı et al.
Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality. This study investigates the cytotoxic effects of Euphorbia rigida extract on A549 NSCLC cells and its potential as a therapeutic agent. Cellular morpholog...