Enhanced Osteoinductivity of Demineralized Bone Matrix with Noggin Suppression in Polymer Matrix [0.03%]
聚合物基质中Noggin抑制增强脱矿骨基质成骨诱导性
Chen Chen,Matthew Rehnama,Soyon Kim et al.
Chen Chen et al.
Demineralized bone matrix (DBM), a potential alternative to autologous bone-graft, has been increasingly used for clinical bone repair; however, its application in larger defects isn't successful partly due to the rapid dispersion of DBM pa...
Enlightening Allostery: Designing Switchable Proteins by Photoreceptor Fusion [0.03%]
光激活 allosteric 蛋白设计的新策略
Jan Mathony,Dominik Niopek
Jan Mathony
Optogenetics harnesses natural photoreceptors to non-invasively control selected processes in cells with previously unmet spatiotemporal precision. Linking the activity of a protein of choice to the conformational state of a photosensor dom...
Markus M Kramer,Wignand W D Mühlhäuser,Wilfried Weber et al.
Markus M Kramer et al.
The precise control of signaling proteins is a prerequisite to decipher the complexity of the signaling network and to reveal and to study pathways involved in regulating cellular metabolism and gene expression. Optogenetic approaches play ...
Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia [0.03%]
光遗传学控制的TrkA活性提高毛囊衍生干细胞分化成神经元和胶质细胞的再生能力
Taida Huang,Yan Zhang,Zitian Wang et al.
Taida Huang et al.
Hair-follicle-derived stem cells (HSCs) originating from the bulge region of the mouse vibrissa hair follicle are able to differentiate into neuronal and glial lineage cells. The tropomyosin receptor kinase A (TrkA) receptor that is express...
Generation of Advanced Blood-Brain Barrier Spheroids Using Human-Induced Pluripotent Stem Cell-Derived Brain Capillary Endothelial-Like Cells [0.03%]
基于人诱导多能干细胞来源的脑血管内皮样细胞的高级血脑屏障球体模型构建
Extensively studied blood-brain barrier (BBB) in-vitro models are established on 2D cell culture inserts. However, they do not accurately represent 3D in-vivo microenvironments due to lack of direct neurovascular unit cellular contacts. Her...