Abhishek Roy,Joseph B Dodd-O,Bobak Shadpoor et al.
Abhishek Roy et al.
Growth factors play a crucial role in regulating cellular processes such as proliferation, differentiation, and survival. Their activities are tightly modulated to ensure proper physiological functioning, with dysregulation often contributi...
Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice [0.03%]
探照新前沿：探索Passiflora属植物在对抗耐甲氧西林金黄色葡萄球菌（MRSA）及其在衰老小鼠中感染的光敏化潜力
Caroline Vieira Gonçalves,Maria Poliana Leite Galantini,Igor Pereira Ribeiro Muniz et al.
Caroline Vieira Gonçalves et al.
Antimicrobial Photodynamic Therapy (aPDT) has become a potential alternative for treating multidrug-resistant bacterial skin infections, such as those caused by methicillin-resistant Staphylococcus aureus (MRSA), which are at high risk in a...
Detecting Dengue in Flight: Leveraging Machine Learning to Analyze Mosquito Flight Patterns for Infection Detection [0.03%]
利用机器学习分析蚊子飞行模式以检测登革热病毒感染
Nouman Javed,Adam J López-Denman,Prasad N Paradkar et al.
Nouman Javed et al.
With the growing global threat of mosquito-borne diseases, there is an urgent need for faster, automated methods to assess disease load in mosquitoes and predict outbreaks. Current surveillance relies on manual mosquito traps and labor-inte...
Optimized Cell-Based Platform for Platelet-Free Detection of Heparin-Induced Thrombocytopenia Antibodies [0.03%]
一种优化的无血小板细胞基质平台用于检测肝素诱导的血小板减少症抗体
Li-Yu Chen,Uwe Schirmer,Peter F Zipfel et al.
Li-Yu Chen et al.
Accurate detection of heparin-induced thrombocytopenia (HIT) antibodies is crucial for diagnosing and managing thrombotic events. Conventional immunoassays, however, often lack specificity and require confirmatory testing with fresh human p...
Cancer Microenvironment-Stimulated Mesenchymal Stem Cells in an Indirect Co-Culture System Influence Cancer Cell Growth and Apoptosis [0.03%]
间接共培养的癌微环境刺激的间充质干细胞影响癌细胞的增殖和凋亡
Pragati Sharma,Jun Nakanishi,Subha Narayan Rath
Pragati Sharma
Mesenchymal stem cells (MSCs) migrate to injured tissues, aiding tissue repair, remodeling, and wound healing. As tumors are often considered to have traits of "injured tissues," MSCs are recruited to tumor microenvironments where they can ...
Phosphorylation-Mediated Regulation of FBXO31 Stability Under Cellular Homeostasis [0.03%]
细胞稳态下FBXO31的磷酸化介导稳定调节机制研究
Leijie Chen,Jinyou Mo,Jia Liu et al.
Leijie Chen et al.
The S-phase kinase-associated protein 1 (Skp1)-Cullin-F-box protein E3 ligase adaptor F-box-only protein 31 (FBXO31) regulates genomic stability and cell signaling in normal, genotoxic, and tumor cells by recognizing and ubiquitinating mult...
Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters [0.03%]
基于激光脉冲参数的红外神经刺激在星形胶质细胞中激活了不同的分子途径
Wilson R Adams,Ana I Borrachero-Conejo,Pratheepa Kumari Rasiah et al.
Wilson R Adams et al.
Label-free optical stimulation of brain cells with infrared (IR) light provides a powerful tool for spatially targeted neuromodulation. However, lingering questions about the off-target effects of IR stimulation on non-neuronal cells remain...
Pathogenesis, Diagnosis Method, and Current Nutritional Support Strategy for Sarcopenia [0.03%]
sarcopenia的发病机制、诊断方法及当前营养支持策略
Yafei Zhang,Kai Zhang,Yi Xue et al.
Yafei Zhang et al.
Sarcopenia is a specific disease that commonly occurs in the elderly and patients with consumptive diseases. Sarcopenia can cause a severe decline in strength and movement, and even lead to prolonged bed rest. Nutritional support is an emer...
Screening and Validation of Negative Regulators of the Type I Interferon Pathway [0.03%]
I型干扰素信号通路的负调控因子筛选与验证
Zhaojun Pang,Han Yang,Bo Li et al.
Zhaojun Pang et al.
Type I interferons （IFN-I） are key proteins in antiviral response and immunomodulation. Negative regulators avoid abnormal activation of the interferon pathway or overactivation of interferon-activating proteins through multiple mechanisms. L...
Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys [0.03%]
双链DNA降低dsRNA在稻小灰吉丁虫唾液中的降解并显著增强RNA介导的基因沉默作用
Venkata Partha Sarathi Amineni,Georg Petschenka,Aline Koch
Venkata Partha Sarathi Amineni
The invasive pest Halyomorpha halys (Hemiptera: Pentatomidae) poses a significant threat to agriculture and requires control methods beyond chemical pesticides. This study investigates RNA interference (RNAi) as a targeted gene silencing ap...