A Pan-Enterovirus Natural Product Inhibitor Targeting a Unique Allosteric Site on the Viral 3C Protease [0.03%]
一种针对病毒3C蛋白酶别构位点的穿肠病毒天然产物抑制剂
Shangwu Sun,Qiang Wang,Mengyao Zhu et al.
Shangwu Sun et al.
Infections caused by Enterovirus like rhinoviruses, coxsackieviruses, and polioviruses represent a significant public health concern, for which there are no antivirals available yet. The highly conserved viral 3C protease has been the prima...
The c-di-GMP Metabolic Gene pdeN Interacts with LacY and ManZ to Modulate Biofilm Formation in Avian Pathogenic Escherichia coli [0.03%]
鸟致病性大肠杆菌中的c-di-GMP代谢基因pdeN通过与LacY和ManZ的相互作用调节生物被膜形成能力
Zhihao Wang,Xiaolong Lv,Lanfang Kong et al.
Zhihao Wang et al.
Bis-(3'-5')-cyclic diguanylic acid (c-di-GMP), a ubiquitous secondary messenger, affects multiple biological characteristics, including biofilm formation in avian pathogenic Escherichia coli (APEC). C-di-GMP is synthesized by diguanylate cy...
Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model [0.03%]
基于间充质基质细胞的动脉粥样硬化斑块帽力学模型：微钙化降低其力学性能
Imke L Jansen,Deniz Şahin,Frank J H Gijsen et al.
Imke L Jansen et al.
Rupture of atherosclerotic plaque caps is the cause of many disabling or lethal cardiovascular events, such as stroke and myocardial infarction. Microcalcifications (
Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno-Free Cultures of Human Adipose Tissue-Derived Stem Cells [0.03%]
福斯克林增强异种培养的人脂肪组织来源干细胞的尿激酶型纤溶酶原激活物分泌和促血管生成作用
Maria Vittoria Giraudo,Anne Therese Lauvrud,Rebecca Wiberg et al.
Maria Vittoria Giraudo et al.
Adipose tissue-derived stem cells (ASCs) hold significant potential for treating various clinical conditions. To enhance their regenerative properties, ASCs can be chemically stimulated using various in vitro protocols. However, unsatisfact...
Research Progress on the Combination of PARP Inhibitors (PARPi) and Immune Checkpoint Inhibitors (ICIs) [0.03%]
PARP抑制剂与免疫检查点抑制剂联合治疗的研究进展
Qi Liu,Chunmei Zhang,Yixuan Gao et al.
Qi Liu et al.
Deficiencies in DNA damage repair (DDR), such as poly (ADP-ribose) polymerase (PARP) deficient, cause cancer development by promoting DNA mutations while also exposing the specificity and vulnerability of cancer to afford a treatment option...
Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications [0.03%]
微生理肾小球滤过屏障：当前认知、创新与未来应用
Manon Miran,Kieu Ngo,David Buob et al.
Manon Miran et al.
Chronic kidney disease (CKD) affects over 850 million individuals worldwide, often progressing to stages requiring dialysis or kidney transplants. Central to kidney function is the glomerular filtration barrier (GFB), which selectively filt...
Chaperone-Mediated Autophagy: A Critical Regulator of Neuroinflammation and Neurodegeneration [0.03%]
伴侣介导的自噬：神经炎症和神经退行性病变的关键调节因子
Ying-Ying Han,Xin-Yue Huang,Ying Su et al.
Ying-Ying Han et al.
Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by hallmark pathological features such as the accumulation of misfolded proteins and neuroinflammation. Chaperone-mediated autoph...
Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine [0.03%]
GALK剂量在克拉布病酶替代疗法中的细胞效应研究支持纳米医药的作用
Ambra Del Grosso,Sara Carpi,Laura Colagiorgio et al.
Ambra Del Grosso et al.
Krabbe disease (KD) is a lysosomal storage disorder characterized by severe neurodegeneration and demyelination. It is caused by mutations in the galactosylceramidase (GALC) gene, leading to the accumulation of psychosine, a neurotoxic meta...
Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease [0.03%]
针对RAGE的纳米抗体在癌症和阿尔茨海默病分子影像中的应用
Guangfeng Liang,Fujing Wang,Wei Xiong et al.
Guangfeng Liang et al.
The receptor for advanced glycation end products (RAGE) is a multifunctional cell surface receptor implicated in aging and the progression of chronic diseases, including cancer and Alzheimer's disease. Its interaction with advanced glycatio...
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats [0.03%]
粪菌移植通过JAK/STAT信号途径调节ARDS大鼠Th17/Treg平衡
Dongwei Zhang,Biying Dong,Jie Chen et al.
Dongwei Zhang et al.
This study evaluated the therapeutic effects of fecal microbiota transplantation (FMT) on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) in rats. The study focused on the balance of T-helper 17 (Th17) and regula...