Pathogenesis, Diagnosis Method, and Current Nutritional Support Strategy for Sarcopenia [0.03%]
sarcopenia的发病机制、诊断方法及当前营养支持策略
Yafei Zhang,Kai Zhang,Yi Xue et al.
Yafei Zhang et al.
Sarcopenia is a specific disease that commonly occurs in the elderly and patients with consumptive diseases. Sarcopenia can cause a severe decline in strength and movement, and even lead to prolonged bed rest. Nutritional support is an emer...
Screening and Validation of Negative Regulators of the Type I Interferon Pathway [0.03%]
I型干扰素信号通路的负调控因子筛选与验证
Zhaojun Pang,Han Yang,Bo Li et al.
Zhaojun Pang et al.
Type I interferons （IFN-I） are key proteins in antiviral response and immunomodulation. Negative regulators avoid abnormal activation of the interferon pathway or overactivation of interferon-activating proteins through multiple mechanisms. L...
Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys [0.03%]
双链DNA降低dsRNA在稻小灰吉丁虫唾液中的降解并显著增强RNA介导的基因沉默作用
Venkata Partha Sarathi Amineni,Georg Petschenka,Aline Koch
Venkata Partha Sarathi Amineni
The invasive pest Halyomorpha halys (Hemiptera: Pentatomidae) poses a significant threat to agriculture and requires control methods beyond chemical pesticides. This study investigates RNA interference (RNAi) as a targeted gene silencing ap...
Microbiome-Mediated Modulation of the Tumour Immune Microenvironment in Oesophageal Squamous Cell Carcinoma [0.03%]
食管鳞状细胞癌中微生物组介导的肿瘤免疫微环境调节作用
Lijing Bai,Anchao Zhu
Lijing Bai
Oesophageal squamous cell carcinoma (ESCC) is the most prevalent type of oesophageal cancer. It is an aggressive malignancy with a poor prognosis, and recent studies have revealed the critical role of the microbiota in its occurrence and de...
3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes [0.03%]
三维乳腺癌体外模型：当前挑战与未来前景——再现微环境和模拟关键过程
Kyndra S Higgins,Ah Joung Yu,Cheryl T Gomillion
Kyndra S Higgins
Each year, ≈1.6 million women are diagnosed with breast cancer worldwide. Of these cases, 0.5 million result in death, with over 90% of these deaths resulting from metastasis. Since it is one of the top 5 cancers with the highest mortality...
Solasonine Restores Sensitivity of Gastric Cancer to NK Cells through DNA Demethylation of MICA [0.03%]
Solasonine通过去甲基化MICA恢复胃癌对NK细胞的敏感性
Tianchuan Li,Ailian Yang,Bingjing He et al.
Tianchuan Li et al.
Solasonine, extracted from Solanum nigrum, has been proven to exert anti-tumor effects in various tumors. However, the role of solasonine in gastric cancer remains unclear. This study aims to elucidate the therapeutic effects of solasonine ...
Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? [0.03%]
局部麻醉药与癌症生物学的交集：现状如何？未来何方？
Eduardo Nunez-Rodriguez,Hao Zhang,Dhananjay Sah et al.
Eduardo Nunez-Rodriguez et al.
Local anesthetics (LAs), commonly used for regional and general anesthesia, have gained attention in recent years for their potential role during cancer curative surgery, as they may reduce cancer recurrence and progression. Studies in both...
Adipose Mesenchymal Stem Cell-Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation [0.03%]
脂肪源性间充质干细胞衍生的外泌体联合罗氟司特通过调节纤维化和炎症改善慢性肾脏病
Mohamed Ali,Mohamed H Sherif,Nashwa Barakat et al.
Mohamed Ali et al.
Adipose mesenchymal stem cell-derived exosomes and the PDE4 inhibitor roflumilast (ROF) are investigated as potential treatments for chronic kidney disease (CKD). The exosomes are extracted and analyzed using electron microscopy and flow cy...
Spheroid Cell Aggregation Enhanced by Enzyme-Free Ultrasound-Detached Cells [0.03%]
一种声波解离细胞的无酶球体化方法
Julien van Delft,Chikahiro Imashiro,Yuta Kurashina et al.
Julien van Delft et al.
Spheroids are being widely studied as potential building blocks for complex organ engineering, tools for drug screening and cancer study. However, formation time has become the bottleneck of applications due to the need for large-scale high...
Activation of NF-κB Signaling by Optogenetic Clustering of IKKα and β [0.03%]
光遗传学聚集IKKα和IKKβ激活NF-κB信号通路
Alexandra Anna Maria Fischer,Markus Michael Kramer,Miguel Baños et al.
Alexandra Anna Maria Fischer et al.
Molecular optogenetics allows the control of molecular signaling pathways in response to light. This enables the analysis of the kinetics of signal activation and propagation in a spatially and temporally resolved manner. A key strategy for...