Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? [0.03%]
局部麻醉药与癌症生物学的交集：现状如何？未来何方？
Eduardo Nunez-Rodriguez,Hao Zhang,Dhananjay Sah et al.
Eduardo Nunez-Rodriguez et al.
Local anesthetics (LAs), commonly used for regional and general anesthesia, have gained attention in recent years for their potential role during cancer curative surgery, as they may reduce cancer recurrence and progression. Studies in both...
Adipose Mesenchymal Stem Cell-Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation [0.03%]
脂肪源性间充质干细胞衍生的外泌体联合罗氟司特通过调节纤维化和炎症改善慢性肾脏病
Mohamed Ali,Mohamed H Sherif,Nashwa Barakat et al.
Mohamed Ali et al.
Adipose mesenchymal stem cell-derived exosomes and the PDE4 inhibitor roflumilast (ROF) are investigated as potential treatments for chronic kidney disease (CKD). The exosomes are extracted and analyzed using electron microscopy and flow cy...
Spheroid Cell Aggregation Enhanced by Enzyme-Free Ultrasound-Detached Cells [0.03%]
一种声波解离细胞的无酶球体化方法
Julien van Delft,Chikahiro Imashiro,Yuta Kurashina et al.
Julien van Delft et al.
Spheroids are being widely studied as potential building blocks for complex organ engineering, tools for drug screening and cancer study. However, formation time has become the bottleneck of applications due to the need for large-scale high...
Activation of NF-κB Signaling by Optogenetic Clustering of IKKα and β [0.03%]
光遗传学聚集IKKα和IKKβ激活NF-κB信号通路
Alexandra Anna Maria Fischer,Markus Michael Kramer,Miguel Baños et al.
Alexandra Anna Maria Fischer et al.
Molecular optogenetics allows the control of molecular signaling pathways in response to light. This enables the analysis of the kinetics of signal activation and propagation in a spatially and temporally resolved manner. A key strategy for...
Fibronectin Peptide Modified Hydrogels Activate a Contractile Phenotype in Nucleus Pulposus Cells [0.03%]
纤维连接蛋白肽修饰的水凝胶激活椎间盘髓核细胞的收缩表型
Ananya Naha,John Sorensen,Santiago Lazarte et al.
Ananya Naha et al.
Degenerative disc disease is strongly associated with low back pain, making it a leading cause of disability. With injury and age, cellular remodeling of the disc tissue leads to compositional changes, stiffening, and loss of stress relaxat...
Mirsadeghi Isfahani Paniz,Rastegar Lari Tina,Darbeheshti Farzaneh et al.
Mirsadeghi Isfahani Paniz et al.
Cancer is one of the most pervasive and severe global diseases that cause millions of death annually. Numerous bacterial strains are found to play fundamental roles in tumor formation, growth, and metastasis. On the other hand, specific bac...
Tumor Immune Engineering: Developing In Vitro Assays to Understand the Tumor-Immune Crosstalk [0.03%]
肿瘤免疫工程：开发体外测定方法以了解肿瘤免疫相互作用
Ranjani N Iyer,Maitreyee Vartak,Tuli Dey
Ranjani N Iyer
Interaction between a growing tumor and the host immune system has various facets, which eventually influence the fate of both the tumor and the host. In the last decade, multiple efforts have been undertaken to mimic the heterogeneous cons...
Luteolin Regulates Mitophagy to Alleviate Myocardial Ischemia-Reperfusion Injury via Sirt3/Foxo3a Pathway [0.03%]
通过Sirt3/Foxo3a途径调节线粒体自噬缓解黄酮类化合物山柰酚的心肌缺血再灌注损伤的作用及机制研究
Li Yan,Lei Liang,Qiling Gou et al.
Li Yan et al.
Luteolin (LUT) belongs to a kind of flavonoid, which has protective effects on myocardial ischemia/reperfusion (I/R) injury. Sirt3 is located in mitochondria and interacts with Foxo3a to protect mitochondrial function against stress. Mitoph...
Diana Corallo,Sara Menegazzo,Marcella Pantile et al.
Diana Corallo et al.
Neuroblastoma represents a major challenge in pediatric oncology with over 50% of cases involving metastasis. High-risk patients face an unfavorable prognosis, with survival rates below 40%. LIN28B plays a pivotal role in neuroblastoma deve...
Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment [0.03%]
谷氨酰胺代谢抑制通过重塑巨噬细胞免疫微环境抑制肿瘤进展
Tianhe Li,Sepehr Akhtarkhavari,Sumeng Qi et al.
Tianhe Li et al.
Targeting glutamine metabolism has emerged as a promising strategy in cancer therapy. To attain clinical utility, a number of challenges must be overcome, including in vivo anti-tumor activity, pharmacological toxicity, and clinical safety....