Amide-Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non-Small Cell Lung Adenocarcinoma [0.03%]
酰胺连接的局部麻醉药通过复杂的非小细胞肺癌腺癌人体组织模型改变肿瘤生物学行为
Juliane Krömer,Sebastian Krämer,Ngoc Anh Hoang et al.
Juliane Krömer et al.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti-inflammatory properties. However, a translation into clinical evidence is still lacking. Here, effects of LA at clinically relevant con...
Glaucocalyxin A Induces Cytotoxicity in Renal Cancer Cells via ROS-Mediated Autophagy by Direct Targeting of Antioxidant Enzymes PRDX1 and PRDX2 [0.03%]
通过直接靶向抗氧化酶PRDX1和PRDX2介导的自噬诱导肾癌细胞 cytotoxicity的Glaucocalyxin A
Yaping Niu,Jinhuan Ou,Xiaoru Zhong et al.
Yaping Niu et al.
Glaucocalyxin A (GLA), a bioactive diterpenoid from the medicinal plant Rabdosia japonica, demonstrates potent antitumor activity, yet its molecular mechanisms in renal cell carcinoma (RCC) remain elusive. Here, GLA is reported to trigger c...
Qianlie Xiaozheng Formula Inhibits Prostate Cancer via the STING/TBK1/IRF3 Pathway by Suppressing CHK1 [0.03%]
虔良小政汤通过抑制CHK1介导的STING/TBK1/IRF3通路发挥抗前列腺癌作用
Xing Zhang,Guanghui Yuan,Yun Chen et al.
Xing Zhang et al.
Qianlie Xiaozheng formula (QLXZF), a multi-herbal TCM prescription, has demonstrated clinical efficacy against prostate cancer (PCa), but its immunomodulatory mechanisms remain elusive. This study aims to explore the molecular mechanisms of...
snoRNP RRP9 Promotes Prostate Cancer Cell Proliferation and Migration via SQSTM1 [0.03%]
SnoRNP RRP9通过SQSTM1促进前列腺癌细胞增殖和迁移
Butang Li,Lihui Shen,Hui Huang et al.
Butang Li et al.
Small nucleolar RNAs (snoRNAs)-60-300 nucleotide non-coding RNAs are associated with adverse clinical outcomes in cancer patients. However, information on the role of snoRNAs and associated small nuclear ribonucleoprotein (snoRNPs) in prost...
SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ [0.03%]
SOX4通过与EBF2和PPARγ的独立复合物调节棕色脂肪组织中的产热作用
Shuai Wang,Ting He,Tong Fu et al.
Shuai Wang et al.
Brown adipose tissue (BAT) is crucial for maintaining whole-body metabolic homeostasis and combating obesity and metabolic disorders. SOX4 collaborates with EBF2 to promote the expression of thermogenic genes in BAT, but it is unclear wheth...
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study [0.03%]
关于黑质衰老的空间分辨视图：一项探索性蛋白质组学研究
Britta Eggers,Maximilian Hausherr,Michel Lim et al.
Britta Eggers et al.
Physiological aging is accompanied by structural and molecular changes in the brain, with varying degrees in different brain areas, and is considered one of the major risk factors for neurodegenerative diseases. Thus, the present study focu...
Advancing Research on Stress, Resilience, and Aging in Transgender Populations [0.03%]
推进跨性别群体压力、复原力和老龄化的研究
Kylie Madhav,Hannah Yore,Monty A Montano
Kylie Madhav
Transgender individuals experience profound health disparities across the life course, shaped by developmental, social, and environmental stressors that accumulate over time. As they age, these disparities manifest in poorer physical and me...
Xin Feng,Wangyu Luo,Yichen Yao et al.
Xin Feng et al.
Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating cellular proliferation, survival, apoptosis, vascularization, immune regulation, and migratory processes. Human Stat3 defici...
RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1 [0.03%]
通过E2F1转录调节CDK1促进食管鳞状细胞癌发展的RRP9基因
Gang He,Yilong Wan,Yanbo Zhu et al.
Gang He et al.
Esophageal cancer is a major disease that seriously threatens human health. Ribosomal RNA biogenesis is implicated in tumorigenesis, while the small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modifications of ribosoma...
Unrolling of Syngonium podophyllum: Functional Anatomy, Morphology and Modelling of Its Peltate Leaves [0.03%]
Syngonium podophyllum叶卷曲的机制：其掌状叶的功能解剖、形态及建模研究
Michelle Modert,Nick Seinsche,Sören Bartels et al.
Michelle Modert et al.
The mechanisms underlying leaf unfolding remain largely speculative and are often inferred from mathematical models. Peltate leaves, unlike typical foliage leaves, frequently emerge in a "rolled-up" state. This study investigates mechanisms...