Biologics, Biosimilars, and Biobetters: Therapeutic Innovations Reshaping Modern Medicine [0.03%]
生物类似药与生物改良药：现代医学治疗创新药物重塑医疗格局
Joseph Carmelo Kalaw San Pascual,Thaned Kangsamaksin
Joseph Carmelo Kalaw San Pascual
Biologic medicines (or biologics) have revolutionized the treatment of cancer, autoimmune disorders, and genetic conditions. Their therapeutic success stems from complex structural properties that confer high target specificity and biologic...
The Paradox of Heme Oxygenase 1: From Cellular Defense to a Tug of War between Cancer Promotion and Prevention [0.03%]
血红素氧合酶1的悖论：从细胞防御到癌症促发与预防的拉锯战
Sidhant Jain,Meenakshi Rana,Nilza Angmo et al.
Sidhant Jain et al.
The Hmox1 enzyme, which is the inducible enzyme among the Hmoxs, catalyzes the first and rate-limiting step in the heme degradation pathway, generating three byproducts, namely, carbon monoxide, free iron, and biliverdin. These byproducts c...
Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone [0.03%]
机械载荷下破骨细胞调控前列腺癌PC-3肿瘤细胞向骨骼早期转移过程中的癌矿物相互作用机制研究
Kimberly Seaman,Bryan Guo,William W Du et al.
Kimberly Seaman et al.
Bone metastasis causes severe complications for patients suffering from advanced-stage prostate cancer. Exercise is recommended to help maintain musculoskeletal health during treatment. As primary mechanosensors and regulators of bone homeo...
Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating [0.03%]
镁及钙涂层生物可降解金属离子的促 osteogenesis作用
Risa Miyake,Masaya Shimabukuro,Masahiko Terauchi et al.
Risa Miyake et al.
This study investigates the effects of ion release and pH elevation from a biodegradable metallic magnesium (Mg) -30 calcium (Ca) coating on osteogenesis using osteoblast-like cells. The coating, formed on titanium (Ti) via magnetron sputte...
Frido Petersen,Simon Westermann,Valeriia Smialkovska et al.
Frido Petersen et al.
The 3D organization of the genome constitutes a spatial layer of information processing that helps govern gene expression and thus cell function. Advances in chromosome conformation capture sequencing have enabled detailed assessment of chr...
Primary Human Tissue Models for Metabolic Dysfunction-Associated Liver Disease - toward Streamlining Drug Discovery with Patient-Derived Assays [0.03%]
代谢功能障碍相关性肝病的原代人类组织模型——用患者衍生的检测手段简化药物发现
Sonia Youhanna,Nayere Taebnia,Yingxin Liang et al.
Sonia Youhanna et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form metabolic dysfunction-associated steatohepatitis (MASH) are prevalent chronic liver diseases that are closely linked to metabolic syndrome, type 2 dia...
A Hierarchical Cascade of Organellar Silencing and Their Regeneration Under Anaesthetic Stress in Plants [0.03%]
植物在麻醉压力下出现的器官亚细胞沉默的级联反应及其再生现象
Shilpa Chandra,Sakshi Chouhan,Bodhidipra Mukherjee et al.
Shilpa Chandra et al.
Anaesthetics temporarily inhibit neural activity by acting on voltage-gated sodium channels and GABA receptors. Although their neurological mechanisms are well-defined, their wider cellular effects, especially in non-neuronal systems, are i...
Targeting Ferroptosis in Nasopharyngeal Carcinoma: Mechanisms of Therapy Resistance and Therapeutic Opportunities [0.03%]
鼻咽癌铁死亡靶向治疗：耐药机制和治疗机会
Dayuan Zheng,Tong Chu,Dongfan Yang et al.
Dayuan Zheng et al.
Nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-driven malignancy with geographic prevalence in Asia, faces therapeutic challenges due to acquired resistance. Ferroptosis-an iron-dependent cell death pathway driven by lipid pero...
Improvement of Pancreatic Beta Cell Functionality with a Collagen Functionalized 3D Platform for Diabetes Treatment [0.03%]
用于糖尿病治疗的胶原功能化三维平台改善胰岛β细胞功能性能
Natalia Moreno-Castellanos,Elías Cuartas-Gómez,Oscar Vargas-Ceballos
Natalia Moreno-Castellanos
Type 1 Diabetes (T1D) is characterized by autoimmune destruction of pancreatic beta cells, resulting in insulin deficiency. Natural-based biomaterials like collagen offer promising avenues mimicking tissue microenvironments. However, limite...
The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization [0.03%]
透明质酸在三维水凝胶支架中的固定可调节巨噬细胞极化
Tiah Cl Oates,Jasmin Boyd,Louise Dolan et al.
Tiah Cl Oates et al.
Macrophages are key modulators of immunity, tissue homeostasis and disease development. As our understanding of macrophage biology and their tissue-specific behaviors grows the necessity to model macrophages within a 3D biomimetic environme...