Optimized Cell-Based Platform for Platelet-Free Detection of Heparin-Induced Thrombocytopenia Antibodies [0.03%]
一种优化的无血小板细胞基质平台用于检测肝素诱导的血小板减少症抗体
Li-Yu Chen,Uwe Schirmer,Peter F Zipfel et al.
Li-Yu Chen et al.
Accurate detection of heparin-induced thrombocytopenia (HIT) antibodies is crucial for diagnosing and managing thrombotic events. Conventional immunoassays, however, often lack specificity and require confirmatory testing with fresh human p...
Cancer Microenvironment-Stimulated Mesenchymal Stem Cells in an Indirect Co-Culture System Influence Cancer Cell Growth and Apoptosis [0.03%]
间接共培养的癌微环境刺激的间充质干细胞影响癌细胞的增殖和凋亡
Pragati Sharma,Jun Nakanishi,Subha Narayan Rath
Pragati Sharma
Mesenchymal stem cells (MSCs) migrate to injured tissues, aiding tissue repair, remodeling, and wound healing. As tumors are often considered to have traits of "injured tissues," MSCs are recruited to tumor microenvironments where they can ...
Phosphorylation-Mediated Regulation of FBXO31 Stability Under Cellular Homeostasis [0.03%]
细胞稳态下FBXO31的磷酸化介导稳定调节机制研究
Leijie Chen,Jinyou Mo,Jia Liu et al.
Leijie Chen et al.
The S-phase kinase-associated protein 1 (Skp1)-Cullin-F-box protein E3 ligase adaptor F-box-only protein 31 (FBXO31) regulates genomic stability and cell signaling in normal, genotoxic, and tumor cells by recognizing and ubiquitinating mult...
Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters [0.03%]
基于激光脉冲参数的红外神经刺激在星形胶质细胞中激活了不同的分子途径
Wilson R Adams,Ana I Borrachero-Conejo,Pratheepa Kumari Rasiah et al.
Wilson R Adams et al.
Label-free optical stimulation of brain cells with infrared (IR) light provides a powerful tool for spatially targeted neuromodulation. However, lingering questions about the off-target effects of IR stimulation on non-neuronal cells remain...
Pathogenesis, Diagnosis Method, and Current Nutritional Support Strategy for Sarcopenia [0.03%]
sarcopenia的发病机制、诊断方法及当前营养支持策略
Yafei Zhang,Kai Zhang,Yi Xue et al.
Yafei Zhang et al.
Sarcopenia is a specific disease that commonly occurs in the elderly and patients with consumptive diseases. Sarcopenia can cause a severe decline in strength and movement, and even lead to prolonged bed rest. Nutritional support is an emer...
Screening and Validation of Negative Regulators of the Type I Interferon Pathway [0.03%]
I型干扰素信号通路的负调控因子筛选与验证
Zhaojun Pang,Han Yang,Bo Li et al.
Zhaojun Pang et al.
Type I interferons （IFN-I） are key proteins in antiviral response and immunomodulation. Negative regulators avoid abnormal activation of the interferon pathway or overactivation of interferon-activating proteins through multiple mechanisms. L...
Double-Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi-Mediated Gene Silencing in Halyomorpha halys [0.03%]
双链DNA降低dsRNA在稻小灰吉丁虫唾液中的降解并显著增强RNA介导的基因沉默作用
Venkata Partha Sarathi Amineni,Georg Petschenka,Aline Koch
Venkata Partha Sarathi Amineni
The invasive pest Halyomorpha halys (Hemiptera: Pentatomidae) poses a significant threat to agriculture and requires control methods beyond chemical pesticides. This study investigates RNA interference (RNAi) as a targeted gene silencing ap...
Microbiome-Mediated Modulation of the Tumour Immune Microenvironment in Oesophageal Squamous Cell Carcinoma [0.03%]
食管鳞状细胞癌中微生物组介导的肿瘤免疫微环境调节作用
Lijing Bai,Anchao Zhu
Lijing Bai
Oesophageal squamous cell carcinoma (ESCC) is the most prevalent type of oesophageal cancer. It is an aggressive malignancy with a poor prognosis, and recent studies have revealed the critical role of the microbiota in its occurrence and de...
3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes [0.03%]
三维乳腺癌体外模型：当前挑战与未来前景——再现微环境和模拟关键过程
Kyndra S Higgins,Ah Joung Yu,Cheryl T Gomillion
Kyndra S Higgins
Each year, ≈1.6 million women are diagnosed with breast cancer worldwide. Of these cases, 0.5 million result in death, with over 90% of these deaths resulting from metastasis. Since it is one of the top 5 cancers with the highest mortality...
Solasonine Restores Sensitivity of Gastric Cancer to NK Cells through DNA Demethylation of MICA [0.03%]
Solasonine通过去甲基化MICA恢复胃癌对NK细胞的敏感性
Tianchuan Li,Ailian Yang,Bingjing He et al.
Tianchuan Li et al.
Solasonine, extracted from Solanum nigrum, has been proven to exert anti-tumor effects in various tumors. However, the role of solasonine in gastric cancer remains unclear. This study aims to elucidate the therapeutic effects of solasonine ...