RAN Promotes Autophagy and Malignant Progression of Lung Adenocarcinoma through ATG101 [0.03%]
RNА结合蛋白RAN通过ATG101促进肺腺癌自噬及恶性进展
Weiyun Bi,Hongtao Li,Xiaoyong Wu et al.
Weiyun Bi et al.
This study investigates the role and mechanisms of Ras-related nuclear protein (RAN) in lung adenocarcinoma (LUAD). The expression of RAN in LUAD is studied using the The Cancer Genome Atlas (TCGA) database. Clinical samples are collected, ...
FOXP3 Polymorphism and Upregulation of the CXCL12-CXCR4-SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients [0.03%]
FOXP3多态性通过STAT3/NF-κB信号通路上调CXCL12-CXCR4-SNAIL轴和M2型肿瘤相关巨噬细胞浸润影响宫颈癌患者的预后
George A Lira,Fábio M de Azevedo,Ingrid G S Lins et al.
George A Lira et al.
This study explores the interaction between immune and cancer cells in the tumor microenvironment (TME) of cervical carcinoma (CC), with emphasis on tumor-associated macrophages (M2-TAMs) and the STAT3-NF-κB signaling pathway. It investiga...
Qingxin Jianpi Decoction Alleviates Cyclophosphamide-Induced Diminished Ovarian Reserve Via Activation of the PI3K/AKT/Nrf2 Axis and Suppression of Ferroptosis [0.03%]
健脾清欣汤通过激活PI3K/AKT/Nrf2轴并抑制铁死亡来改善环磷酰胺诱导的卵巢功能储备减退
Donglai Hu,Jiayu Shi,Yao Peng et al.
Donglai Hu et al.
Diminished ovarian reserve (DOR), marked by reduced oocyte quantity and quality, remains therapeutically challenging. This study evaluates the protective effects of Qingxin Jianpi Decoction (QXJP) against cyclophosphamide (CTX)-induced DOR ...
Biologics, Biosimilars, and Biobetters: Therapeutic Innovations Reshaping Modern Medicine [0.03%]
生物类似药与生物改良药：现代医学治疗创新药物重塑医疗格局
Joseph Carmelo Kalaw San Pascual,Thaned Kangsamaksin
Joseph Carmelo Kalaw San Pascual
Biologic medicines (or biologics) have revolutionized the treatment of cancer, autoimmune disorders, and genetic conditions. Their therapeutic success stems from complex structural properties that confer high target specificity and biologic...
The Paradox of Heme Oxygenase 1: From Cellular Defense to a Tug of War between Cancer Promotion and Prevention [0.03%]
血红素氧合酶1的悖论：从细胞防御到癌症促发与预防的拉锯战
Sidhant Jain,Meenakshi Rana,Nilza Angmo et al.
Sidhant Jain et al.
The Hmox1 enzyme, which is the inducible enzyme among the Hmoxs, catalyzes the first and rate-limiting step in the heme degradation pathway, generating three byproducts, namely, carbon monoxide, free iron, and biliverdin. These byproducts c...
Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone [0.03%]
机械载荷下破骨细胞调控前列腺癌PC-3肿瘤细胞向骨骼早期转移过程中的癌矿物相互作用机制研究
Kimberly Seaman,Bryan Guo,William W Du et al.
Kimberly Seaman et al.
Bone metastasis causes severe complications for patients suffering from advanced-stage prostate cancer. Exercise is recommended to help maintain musculoskeletal health during treatment. As primary mechanosensors and regulators of bone homeo...
Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating [0.03%]
镁及钙涂层生物可降解金属离子的促 osteogenesis作用
Risa Miyake,Masaya Shimabukuro,Masahiko Terauchi et al.
Risa Miyake et al.
This study investigates the effects of ion release and pH elevation from a biodegradable metallic magnesium (Mg) -30 calcium (Ca) coating on osteogenesis using osteoblast-like cells. The coating, formed on titanium (Ti) via magnetron sputte...
Frido Petersen,Simon Westermann,Valeriia Smialkovska et al.
Frido Petersen et al.
The 3D organization of the genome constitutes a spatial layer of information processing that helps govern gene expression and thus cell function. Advances in chromosome conformation capture sequencing have enabled detailed assessment of chr...
Primary Human Tissue Models for Metabolic Dysfunction-Associated Liver Disease - toward Streamlining Drug Discovery with Patient-Derived Assays [0.03%]
代谢功能障碍相关性肝病的原代人类组织模型——用患者衍生的检测手段简化药物发现
Sonia Youhanna,Nayere Taebnia,Yingxin Liang et al.
Sonia Youhanna et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form metabolic dysfunction-associated steatohepatitis (MASH) are prevalent chronic liver diseases that are closely linked to metabolic syndrome, type 2 dia...
A Hierarchical Cascade of Organellar Silencing and Their Regeneration Under Anaesthetic Stress in Plants [0.03%]
植物在麻醉压力下出现的器官亚细胞沉默的级联反应及其再生现象
Shilpa Chandra,Sakshi Chouhan,Bodhidipra Mukherjee et al.
Shilpa Chandra et al.
Anaesthetics temporarily inhibit neural activity by acting on voltage-gated sodium channels and GABA receptors. Although their neurological mechanisms are well-defined, their wider cellular effects, especially in non-neuronal systems, are i...