HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate [0.03%]
HK1和HK2：超越糖酵解的线粒体相互作用及其在代谢和细胞命运决定中的双重角色
Noemi Anna Pesce,Giulia Seminara,Giuseppe Giarrusso et al.
Noemi Anna Pesce et al.
HK1 and HK2 are increasingly recognized not only as glycolytic enzymes but also as key modulators of mitochondrial function and cell fate through dynamic interactions with VDAC. This review explores how HK-VDAC complexes support metabolic f...
Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis [0.03%]
雄性生殖腺移植到成年雌鼠后的功能整合进入下丘脑-垂体-性腺轴
Daniel R Pfau,Monica A Rionda,Evelyn Cho et al.
Daniel R Pfau et al.
Gender-affirming hormone therapy (GAHT) relies on exogenous hormones to produce hormonal milieus that achieve and/or maintain embodiment goals. Another potential route to these endpoints is transplantation of novel steroidogenic tissue. To ...
Recent Advances in Bio-Based Production of Free Heme Using Microbial Metabolic Engineering [0.03%]
基于微生物代谢工程的生物基游离血红素生产研究进展
Wenya Wang,Haitao Geng,Xuting Sun et al.
Wenya Wang et al.
Heme is an iron-containing porphyrin that plays an indispensable role in biological system, involved in oxygen transport, electron transfer, gas sensing, enzyme catalysis, etc. Beyond its physiological functions, heme also has wide-ranging ...
Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro [0.03%]
体外针对肺癌模型的分化治疗可减少病原特征
Grossi Alice,Fulghieri Paola,Aduvaliev Abdurakhmon et al.
Grossi Alice et al.
Non-small cell lung cancer (NSCLC) relapse after therapy is linked to the high aggressiveness, chemoresistance and metastatic potential of tumor cells due, in part, to the presence of cancer stem cells (CSCs). Pro-differentiation approaches...
Electroacupuncture Improves Cardiac Function in Mice with Myocardial Infarction through Glu Neurons in Ventrolateral Periaqueductal Gray [0.03%]
电针通过脑导水管周围灰质腹外侧神经元改善心肌梗死小鼠心脏功能
Liu Yang,Nan Deng,Fan Zhang et al.
Liu Yang et al.
Ischemic heart disease, a leading global cause of mortality, highlights the need for novel therapies. Electroacupuncture (EA) shows cardioprotective potential, yet the central neural mechanisms, particularly the role of the midbrain periaqu...
What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation? [0.03%]
巨噬细胞招募的T细胞活化中大型:endosomal分选复合体必要的转运的作用是什么？
Anthi Psoma,Femmy C Stempels,Rinse de Boer et al.
Anthi Psoma et al.
Our lab recently discovered uniquely large (multiple micrometres) ring-shaped cellular structures composed of endosomal sorting complexes required for transport (ESCRT) proteins. These structures are formed by tissue infiltrating fibroblast...
Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome [0.03%]
仿生肺生理系统验证了急性呼吸窘迫综合症的新细胞疗法
Bokyong Kim,So-Hui Kim,Jieun Kim et al.
Bokyong Kim et al.
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and lung damage, leading to critical hypoxemia. Despite its high mortality rate, the only currently available treatment, Dexamet...
RAN Promotes Autophagy and Malignant Progression of Lung Adenocarcinoma through ATG101 [0.03%]
RNА结合蛋白RAN通过ATG101促进肺腺癌自噬及恶性进展
Weiyun Bi,Hongtao Li,Xiaoyong Wu et al.
Weiyun Bi et al.
This study investigates the role and mechanisms of Ras-related nuclear protein (RAN) in lung adenocarcinoma (LUAD). The expression of RAN in LUAD is studied using the The Cancer Genome Atlas (TCGA) database. Clinical samples are collected, ...
FOXP3 Polymorphism and Upregulation of the CXCL12-CXCR4-SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients [0.03%]
FOXP3多态性通过STAT3/NF-κB信号通路上调CXCL12-CXCR4-SNAIL轴和M2型肿瘤相关巨噬细胞浸润影响宫颈癌患者的预后
George A Lira,Fábio M de Azevedo,Ingrid G S Lins et al.
George A Lira et al.
This study explores the interaction between immune and cancer cells in the tumor microenvironment (TME) of cervical carcinoma (CC), with emphasis on tumor-associated macrophages (M2-TAMs) and the STAT3-NF-κB signaling pathway. It investiga...
Qingxin Jianpi Decoction Alleviates Cyclophosphamide-Induced Diminished Ovarian Reserve Via Activation of the PI3K/AKT/Nrf2 Axis and Suppression of Ferroptosis [0.03%]
健脾清欣汤通过激活PI3K/AKT/Nrf2轴并抑制铁死亡来改善环磷酰胺诱导的卵巢功能储备减退
Donglai Hu,Jiayu Shi,Yao Peng et al.
Donglai Hu et al.
Diminished ovarian reserve (DOR), marked by reduced oocyte quantity and quality, remains therapeutically challenging. This study evaluates the protective effects of Qingxin Jianpi Decoction (QXJP) against cyclophosphamide (CTX)-induced DOR ...