snoRNP RRP9 Promotes Prostate Cancer Cell Proliferation and Migration via SQSTM1 [0.03%]
SnoRNP RRP9通过SQSTM1促进前列腺癌细胞增殖和迁移
Butang Li,Lihui Shen,Hui Huang et al.
Butang Li et al.
Small nucleolar RNAs (snoRNAs)-60-300 nucleotide non-coding RNAs are associated with adverse clinical outcomes in cancer patients. However, information on the role of snoRNAs and associated small nuclear ribonucleoprotein (snoRNPs) in prost...
SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ [0.03%]
SOX4通过与EBF2和PPARγ的独立复合物调节棕色脂肪组织中的产热作用
Shuai Wang,Ting He,Tong Fu et al.
Shuai Wang et al.
Brown adipose tissue (BAT) is crucial for maintaining whole-body metabolic homeostasis and combating obesity and metabolic disorders. SOX4 collaborates with EBF2 to promote the expression of thermogenic genes in BAT, but it is unclear wheth...
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study [0.03%]
关于黑质衰老的空间分辨视图：一项探索性蛋白质组学研究
Britta Eggers,Maximilian Hausherr,Michel Lim et al.
Britta Eggers et al.
Physiological aging is accompanied by structural and molecular changes in the brain, with varying degrees in different brain areas, and is considered one of the major risk factors for neurodegenerative diseases. Thus, the present study focu...
Advancing Research on Stress, Resilience, and Aging in Transgender Populations [0.03%]
推进跨性别群体压力、复原力和老龄化的研究
Kylie Madhav,Hannah Yore,Monty A Montano
Kylie Madhav
Transgender individuals experience profound health disparities across the life course, shaped by developmental, social, and environmental stressors that accumulate over time. As they age, these disparities manifest in poorer physical and me...
Xin Feng,Wangyu Luo,Yichen Yao et al.
Xin Feng et al.
Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating cellular proliferation, survival, apoptosis, vascularization, immune regulation, and migratory processes. Human Stat3 defici...
RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1 [0.03%]
通过E2F1转录调节CDK1促进食管鳞状细胞癌发展的RRP9基因
Gang He,Yilong Wan,Yanbo Zhu et al.
Gang He et al.
Esophageal cancer is a major disease that seriously threatens human health. Ribosomal RNA biogenesis is implicated in tumorigenesis, while the small nucleolar RNAs (snoRNAs) are responsible for post-transcriptional modifications of ribosoma...
Unrolling of Syngonium podophyllum: Functional Anatomy, Morphology and Modelling of Its Peltate Leaves [0.03%]
Syngonium podophyllum叶卷曲的机制：其掌状叶的功能解剖、形态及建模研究
Michelle Modert,Nick Seinsche,Sören Bartels et al.
Michelle Modert et al.
The mechanisms underlying leaf unfolding remain largely speculative and are often inferred from mathematical models. Peltate leaves, unlike typical foliage leaves, frequently emerge in a "rolled-up" state. This study investigates mechanisms...
Abhishek Roy,Joseph B Dodd-O,Bobak Shadpoor et al.
Abhishek Roy et al.
Growth factors play a crucial role in regulating cellular processes such as proliferation, differentiation, and survival. Their activities are tightly modulated to ensure proper physiological functioning, with dysregulation often contributi...
Illuminating New Frontiers: Exploring the Photosensitizing Potential of Passiflora Species in Combating Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Infection in Senescent Mice [0.03%]
探照新前沿：探索Passiflora属植物在对抗耐甲氧西林金黄色葡萄球菌（MRSA）及其在衰老小鼠中感染的光敏化潜力
Caroline Vieira Gonçalves,Maria Poliana Leite Galantini,Igor Pereira Ribeiro Muniz et al.
Caroline Vieira Gonçalves et al.
Antimicrobial Photodynamic Therapy (aPDT) has become a potential alternative for treating multidrug-resistant bacterial skin infections, such as those caused by methicillin-resistant Staphylococcus aureus (MRSA), which are at high risk in a...
Detecting Dengue in Flight: Leveraging Machine Learning to Analyze Mosquito Flight Patterns for Infection Detection [0.03%]
利用机器学习分析蚊子飞行模式以检测登革热病毒感染
Nouman Javed,Adam J López-Denman,Prasad N Paradkar et al.
Nouman Javed et al.
With the growing global threat of mosquito-borne diseases, there is an urgent need for faster, automated methods to assess disease load in mosquitoes and predict outbreaks. Current surveillance relies on manual mosquito traps and labor-inte...