A tumor Microenvironment-Derived Prognostic Model Guides IL-27 as a Therapeutic Strategy to Restore T Cell Immunity in Lung Adenocarcinoma [0.03%]
基于肿瘤微环境的预后模型指导IL-27作为恢复肺癌腺癌T细胞免疫的治疗策略
Gaopu Xie,Donglin Cai,Gang Zhang et al.
Gaopu Xie et al.
Lung adenocarcinoma (LUAD) exhibits substantial heterogeneity in tumor immune microenvironment (TIME) composition, shaping disease progression and therapeutic response. Here, we integrated transcriptomic and clinical data from TCGA-LUAD to ...
Microfluidic-Based Analysis of Trichomonas Vaginalis Attachment and Drug Response Using AI-Based Imaging Algorithm [0.03%]
基于微流控的AI图像处理算法在阴道毛滴虫黏附及药敏分析中的应用研究
Kin Fong Lei,Boreddy Sai Kiran Reddy,Hong-Wei Luo et al.
Kin Fong Lei et al.
T. vaginalis is a protozoan parasite responsible for the most common non-viral sexually transmitted infection worldwide. Effective therapeutic evaluation is essential, particularly with rising concerns over drug resistance. In this study, w...
Synergistic Roles of FAHD-1 and PYC-1 in Mitochondrial Function, Behavior, and Longevity in C. elegans [0.03%]
FAHD-1和PYC-1在秀丽隐杆线虫线粒体功能、行为及寿命中的协同作用
Riccardo Giaquinta,Andreas Andric,Matthias Scheppach et al.
Riccardo Giaquinta et al.
Mitochondrial metabolism plays a central role in organismal physiology and aging. In Caenorhabditis elegans, FAHD-1 (oxaloacetate decarboxylase) and PYC-1 (pyruvate carboxylase) catalyze opposing reactions that influence oxaloacetate homeos...
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate [0.03%]
HK1和HK2：超越糖酵解的线粒体相互作用及其在代谢和细胞命运决定中的双重角色
Noemi Anna Pesce,Giulia Seminara,Giuseppe Giarrusso et al.
Noemi Anna Pesce et al.
HK1 and HK2 are increasingly recognized not only as glycolytic enzymes but also as key modulators of mitochondrial function and cell fate through dynamic interactions with VDAC. This review explores how HK-VDAC complexes support metabolic f...
Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis [0.03%]
雄性生殖腺移植到成年雌鼠后的功能整合进入下丘脑-垂体-性腺轴
Daniel R Pfau,Monica A Rionda,Evelyn Cho et al.
Daniel R Pfau et al.
Gender-affirming hormone therapy (GAHT) relies on exogenous hormones to produce hormonal milieus that achieve and/or maintain embodiment goals. Another potential route to these endpoints is transplantation of novel steroidogenic tissue. To ...
Recent Advances in Bio-Based Production of Free Heme Using Microbial Metabolic Engineering [0.03%]
基于微生物代谢工程的生物基游离血红素生产研究进展
Wenya Wang,Haitao Geng,Xuting Sun et al.
Wenya Wang et al.
Heme is an iron-containing porphyrin that plays an indispensable role in biological system, involved in oxygen transport, electron transfer, gas sensing, enzyme catalysis, etc. Beyond its physiological functions, heme also has wide-ranging ...
Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro [0.03%]
体外针对肺癌模型的分化治疗可减少病原特征
Grossi Alice,Fulghieri Paola,Aduvaliev Abdurakhmon et al.
Grossi Alice et al.
Non-small cell lung cancer (NSCLC) relapse after therapy is linked to the high aggressiveness, chemoresistance and metastatic potential of tumor cells due, in part, to the presence of cancer stem cells (CSCs). Pro-differentiation approaches...
Electroacupuncture Improves Cardiac Function in Mice with Myocardial Infarction through Glu Neurons in Ventrolateral Periaqueductal Gray [0.03%]
电针通过脑导水管周围灰质腹外侧神经元改善心肌梗死小鼠心脏功能
Liu Yang,Nan Deng,Fan Zhang et al.
Liu Yang et al.
Ischemic heart disease, a leading global cause of mortality, highlights the need for novel therapies. Electroacupuncture (EA) shows cardioprotective potential, yet the central neural mechanisms, particularly the role of the midbrain periaqu...
What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation? [0.03%]
巨噬细胞招募的T细胞活化中大型:endosomal分选复合体必要的转运的作用是什么？
Anthi Psoma,Femmy C Stempels,Rinse de Boer et al.
Anthi Psoma et al.
Our lab recently discovered uniquely large (multiple micrometres) ring-shaped cellular structures composed of endosomal sorting complexes required for transport (ESCRT) proteins. These structures are formed by tissue infiltrating fibroblast...
Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome [0.03%]
仿生肺生理系统验证了急性呼吸窘迫综合症的新细胞疗法
Bokyong Kim,So-Hui Kim,Jieun Kim et al.
Bokyong Kim et al.
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and lung damage, leading to critical hypoxemia. Despite its high mortality rate, the only currently available treatment, Dexamet...