Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating [0.03%]
镁及钙涂层生物可降解金属离子的促 osteogenesis作用
Risa Miyake,Masaya Shimabukuro,Masahiko Terauchi et al.
Risa Miyake et al.
This study investigates the effects of ion release and pH elevation from a biodegradable metallic magnesium (Mg) -30 calcium (Ca) coating on osteogenesis using osteoblast-like cells. The coating, formed on titanium (Ti) via magnetron sputte...
Frido Petersen,Simon Westermann,Valeriia Smialkovska et al.
Frido Petersen et al.
The 3D organization of the genome constitutes a spatial layer of information processing that helps govern gene expression and thus cell function. Advances in chromosome conformation capture sequencing have enabled detailed assessment of chr...
Primary Human Tissue Models for Metabolic Dysfunction-Associated Liver Disease - toward Streamlining Drug Discovery with Patient-Derived Assays [0.03%]
代谢功能障碍相关性肝病的原代人类组织模型——用患者衍生的检测手段简化药物发现
Sonia Youhanna,Nayere Taebnia,Yingxin Liang et al.
Sonia Youhanna et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form metabolic dysfunction-associated steatohepatitis (MASH) are prevalent chronic liver diseases that are closely linked to metabolic syndrome, type 2 dia...
A Hierarchical Cascade of Organellar Silencing and Their Regeneration Under Anaesthetic Stress in Plants [0.03%]
植物在麻醉压力下出现的器官亚细胞沉默的级联反应及其再生现象
Shilpa Chandra,Sakshi Chouhan,Bodhidipra Mukherjee et al.
Shilpa Chandra et al.
Anaesthetics temporarily inhibit neural activity by acting on voltage-gated sodium channels and GABA receptors. Although their neurological mechanisms are well-defined, their wider cellular effects, especially in non-neuronal systems, are i...
Targeting Ferroptosis in Nasopharyngeal Carcinoma: Mechanisms of Therapy Resistance and Therapeutic Opportunities [0.03%]
鼻咽癌铁死亡靶向治疗：耐药机制和治疗机会
Dayuan Zheng,Tong Chu,Dongfan Yang et al.
Dayuan Zheng et al.
Nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-driven malignancy with geographic prevalence in Asia, faces therapeutic challenges due to acquired resistance. Ferroptosis-an iron-dependent cell death pathway driven by lipid pero...
Improvement of Pancreatic Beta Cell Functionality with a Collagen Functionalized 3D Platform for Diabetes Treatment [0.03%]
用于糖尿病治疗的胶原功能化三维平台改善胰岛β细胞功能性能
Natalia Moreno-Castellanos,Elías Cuartas-Gómez,Oscar Vargas-Ceballos
Natalia Moreno-Castellanos
Type 1 Diabetes (T1D) is characterized by autoimmune destruction of pancreatic beta cells, resulting in insulin deficiency. Natural-based biomaterials like collagen offer promising avenues mimicking tissue microenvironments. However, limite...
The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization [0.03%]
透明质酸在三维水凝胶支架中的固定可调节巨噬细胞极化
Tiah Cl Oates,Jasmin Boyd,Louise Dolan et al.
Tiah Cl Oates et al.
Macrophages are key modulators of immunity, tissue homeostasis and disease development. As our understanding of macrophage biology and their tissue-specific behaviors grows the necessity to model macrophages within a 3D biomimetic environme...
Amide-Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non-Small Cell Lung Adenocarcinoma [0.03%]
酰胺连接的局部麻醉药通过复杂的非小细胞肺癌腺癌人体组织模型改变肿瘤生物学行为
Juliane Krömer,Sebastian Krämer,Ngoc Anh Hoang et al.
Juliane Krömer et al.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti-inflammatory properties. However, a translation into clinical evidence is still lacking. Here, effects of LA at clinically relevant con...
Glaucocalyxin A Induces Cytotoxicity in Renal Cancer Cells via ROS-Mediated Autophagy by Direct Targeting of Antioxidant Enzymes PRDX1 and PRDX2 [0.03%]
通过直接靶向抗氧化酶PRDX1和PRDX2介导的自噬诱导肾癌细胞 cytotoxicity的Glaucocalyxin A
Yaping Niu,Jinhuan Ou,Xiaoru Zhong et al.
Yaping Niu et al.
Glaucocalyxin A (GLA), a bioactive diterpenoid from the medicinal plant Rabdosia japonica, demonstrates potent antitumor activity, yet its molecular mechanisms in renal cell carcinoma (RCC) remain elusive. Here, GLA is reported to trigger c...
Qianlie Xiaozheng Formula Inhibits Prostate Cancer via the STING/TBK1/IRF3 Pathway by Suppressing CHK1 [0.03%]
虔良小政汤通过抑制CHK1介导的STING/TBK1/IRF3通路发挥抗前列腺癌作用
Xing Zhang,Guanghui Yuan,Yun Chen et al.
Xing Zhang et al.
Qianlie Xiaozheng formula (QLXZF), a multi-herbal TCM prescription, has demonstrated clinical efficacy against prostate cancer (PCa), but its immunomodulatory mechanisms remain elusive. This study aims to explore the molecular mechanisms of...