Oncogenic miR-182-5p Targets NCOA4 to Disrupt the NCOA4-FTH1 Axis-Mediated Ferroptosis in Head and Neck Squamous Cell Carcinoma [0.03%]
miR-182-5p通过靶向NCOA4介导的NCOA4-FTH1轴诱导头颈鳞癌细胞铁死亡的抗肿瘤作用研究
Wulin Wen,Jia Zhao,Wuxia Zhao et al.
Wulin Wen et al.
Head and neck squamous cell carcinoma (HNSCC) is characterized by a high recurrence rate and poor prognosis. Ferroptosis, a regulated cell death, plays a significant role in inhibiting tumor progression. However, its role and regulatory mec...
HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung-Associated Enterocolitis [0.03%]
Hirschsprung病相关性坏死肠炎中来源于吡咯烷的HMGB1促进巨噬细胞胞外陷阱形成
Rui Zhang,Jing Li,Lili Song et al.
Rui Zhang et al.
Hirschsprung-associated enterocolitis (HAEC) is the most common and severe complication in patients with Hirschsprung's disease (HSCR) and is characterized by high morbidity, frequent recurrence and substantial mortality. The formation of m...
Apolipoprotein A-I Binding Protein: Functions, Mechanisms, and Therapeutic Targets in Neurological Disorders [0.03%]
载脂蛋白A-I结合蛋白：在神经疾病中的功能、机制和治疗靶点
Zijian Zhang,Yingjun Wang,Hao Yang et al.
Zijian Zhang et al.
Apolipoprotein A-I binding protein (AIBP) interacts with both apolipoprotein A-I and high-density lipoprotein. It modulates lipid raft-related signaling pathways and affects mitochondrial function, oxidative stress, and inflammatory respons...
Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts - from General Tissue Engineering to Cellular Agriculture [0.03%]
超分子方法工程化模块水凝胶培养原生质体平台——从通用组织工程到细胞农业
Maritza M Rovers,Erik J Slootweg,Ferdinand C O Los et al.
Maritza M Rovers et al.
Protoplast regeneration into plant cells and further into plants is an ongoing challenge in agricultural biotechnology. Inspired by mammalian tissue engineering, a strategic shift is proposed in plant tissue engineering to steer protoplast ...
Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum) [0.03%]
墨西哥钝头螈（Ambystoma_mexicanum）成年后跳跃基因表达上调，肢体再生过程中则被抑制
Samuel Ruiz-Pérez,Nicolás Alcaraz,Karla Torres-Arciga et al.
Samuel Ruiz-Pérez et al.
The axolotl (Ambystoma mexicanum) has a great capacity to regenerate its tissues; however, the fidelity and success of its regenerative process diminish with age. Retrotransposons make up the largest portion of the axolotl genome, and their...
Flow Cytometry and Gene Expression Modulation by Euphorbia rigida Methanol Extract in A549 Lung Cancer Cells: Induction of Apoptosis Through Bax, Caspase-9, and Bcl-2 Pathways [0.03%]
Euphorbia rigida 甲醇提取物对A549肺癌细胞流式分析及基因表达调控作用：通过Bax、Caspase-9和Bcl-2诱导凋亡路径
Zeynep Betül Sarı,Muhammed Emin Sarı,Erdi Can Aytar et al.
Zeynep Betül Sarı et al.
Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality. This study investigates the cytotoxic effects of Euphorbia rigida extract on A549 NSCLC cells and its potential as a therapeutic agent. Cellular morpholog...
IFN-γ Synergizes with TNF-α to Induce RIPK1-Independent Necroptosis of Mesenchymal Stem/Stromal Cells [0.03%]
干扰素γ与肿瘤坏死因子α协同诱导间充质干细胞非受体相互作用蛋白1依赖型坏死性凋亡
Ren Xiang,Huo Jiali,Li Xingxin et al.
Ren Xiang et al.
IFN-γ and TNF-α are two vital inflammatory factors elevated aberrantly in many diseases. Such an inflammatory microenvironment is detrimental to residual cells such as mesenchymal stem cells (MSCs), yet the precise mechanisms are not full...
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses [0.03%]
靶向铁死亡可缓解肺动脉高压 小鼠转录组和实验分析提供新见解
Xiaowan Wang,Qiang Guo
Xiaowan Wang
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling driven by endothelial cell injury. This study investigates the role of ferroptosis in PAH development and its underlying molecular mechanisms. Ferroptos...
Guilongwan Ameliorates Experimental Diabetic Foot Ulcer in Rats via the Inhibition of Delta-Like 4/Notch1 Signaling in M1 Macrophages [0.03%]
归龙丸通过抑制M1型巨噬细胞DLL4/NOTCH1信号通路改善糖尿病足溃疡动物模型的功效学研究
Xi-Ting Lv,Wen-Xiu Yang,Xiao Zhang et al.
Xi-Ting Lv et al.
Guilongwan (GLW), a representative of traditional Chinese Medicine (TCM) has been utilized to treating diabetic foot ulcer (DFU)-related syndrome including an intolerance of cold with cold limbs, blood circulation disorder, and immune dysfu...
Brigitte Städler,Alexander N Zelikin,Julián Valero et al.
Brigitte Städler et al.