Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine [0.03%]
GALK剂量在克拉布病酶替代疗法中的细胞效应研究支持纳米医药的作用
Ambra Del Grosso,Sara Carpi,Laura Colagiorgio et al.
Ambra Del Grosso et al.
Krabbe disease (KD) is a lysosomal storage disorder characterized by severe neurodegeneration and demyelination. It is caused by mutations in the galactosylceramidase (GALC) gene, leading to the accumulation of psychosine, a neurotoxic meta...
Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease [0.03%]
针对RAGE的纳米抗体在癌症和阿尔茨海默病分子影像中的应用
Guangfeng Liang,Fujing Wang,Wei Xiong et al.
Guangfeng Liang et al.
The receptor for advanced glycation end products (RAGE) is a multifunctional cell surface receptor implicated in aging and the progression of chronic diseases, including cancer and Alzheimer's disease. Its interaction with advanced glycatio...
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats [0.03%]
粪菌移植通过JAK/STAT信号途径调节ARDS大鼠Th17/Treg平衡
Dongwei Zhang,Biying Dong,Jie Chen et al.
Dongwei Zhang et al.
This study evaluated the therapeutic effects of fecal microbiota transplantation (FMT) on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) in rats. The study focused on the balance of T-helper 17 (Th17) and regula...
Lithocholic Acid, Calorie Restriction, and Halting Aging [0.03%]
鹅膏蕈碱、限制卡路里和抗衰老机制关系的实验研究——胆石酸的发现及其机理
Cade Ward,Michael M Shahid,Grace Hohman et al.
Cade Ward et al.
While aging is a natural biological process, it is associated with a greater risk for multiple diseases, including cancer, neurodegeneration, and cardiovascular disease. Thus, it is important to study the biochemical mechanisms involved in ...
Precision Medicine in ICH Unveiling the Superior Predictive Power of a Joint Model [0.03%]
ICH中的精准医疗：联合模型预测能力的提升
Fa Wu,YuLin Yang,TingTing Wu et al.
Fa Wu et al.
This study examined the effectiveness of a combined model using non-contrast computed tomography (NCCT) imaging, clinical data, and radiomics for predicting early hematoma enlargement in patients with spontaneous intracerebral hemorrhage. T...
Kieran F Reid
Kieran F Reid
Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells [0.03%]
过度吸入氧气诱导人骨髓基质细胞染色质结构的改变
Lauren Monroe,Samantha Kaonis,Natalie Calahan et al.
Lauren Monroe et al.
In eukaryotic cell nuclei, chromatin exhibits a high degree of structural and functional dynamics. Recent findings suggest that chromatin has the ability to reorganize in response to changes within the cellular microenvironment. Such change...
Oncogenic miR-182-5p Targets NCOA4 to Disrupt the NCOA4-FTH1 Axis-Mediated Ferroptosis in Head and Neck Squamous Cell Carcinoma [0.03%]
miR-182-5p通过靶向NCOA4介导的NCOA4-FTH1轴诱导头颈鳞癌细胞铁死亡的抗肿瘤作用研究
Wulin Wen,Jia Zhao,Wuxia Zhao et al.
Wulin Wen et al.
Head and neck squamous cell carcinoma (HNSCC) is characterized by a high recurrence rate and poor prognosis. Ferroptosis, a regulated cell death, plays a significant role in inhibiting tumor progression. However, its role and regulatory mec...
HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung-Associated Enterocolitis [0.03%]
Hirschsprung病相关性坏死肠炎中来源于吡咯烷的HMGB1促进巨噬细胞胞外陷阱形成
Rui Zhang,Jing Li,Lili Song et al.
Rui Zhang et al.
Hirschsprung-associated enterocolitis (HAEC) is the most common and severe complication in patients with Hirschsprung's disease (HSCR) and is characterized by high morbidity, frequent recurrence and substantial mortality. The formation of m...
Apolipoprotein A-I Binding Protein: Functions, Mechanisms, and Therapeutic Targets in Neurological Disorders [0.03%]
载脂蛋白A-I结合蛋白：在神经疾病中的功能、机制和治疗靶点
Zijian Zhang,Yingjun Wang,Hao Yang et al.
Zijian Zhang et al.
Apolipoprotein A-I binding protein (AIBP) interacts with both apolipoprotein A-I and high-density lipoprotein. It modulates lipid raft-related signaling pathways and affects mitochondrial function, oxidative stress, and inflammatory respons...