Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1-FoxO1-FoxO3-Autophagy Pathway [0.03%]
SIRT1活化通过SIRT1-FoxO1-FoxO3-自噬途径减少缺氧下肾小管上皮细胞纤维化
Guangyu Wang,Lijuan Zhang,Jiaorong Tan et al.
Guangyu Wang et al.
Heart failure-induced renal tubular epithelial cell fibrosis is an important pathological process that leads to chronic kidney disease. This study is to investigate the regulatory mechanism of over-expression or knock-down SIRT1 gene, allev...
Phytomolecule Epimedin C Mitigates Cartilage Extracellular Matrix Degradation and Osteoarthritis Progression in Rats [0.03%]
淫羊藿次素C减轻膝关节软骨基质降解和滑膜炎症，抑制骨关节炎进展
Wenyao Yang,Xiangbo Meng,Jiming Li et al.
Wenyao Yang et al.
Osteoarthritis (OA) is a common degenerative joint disease associated with chronic inflammation. Epimedin C (EpiC), flavonoid from Epimedin, enhances the extracellular matrix (ECM) expression in human chondrocytes in vitro. This study aims ...
Endurance Exercise Training Alleviates Hepatic Lipocalin-2 Release and Prevents Anxiety-Like Disorders in Chronically Stressed Mice [0.03%]
耐力运动训练缓解慢性应激小鼠肝细胞脂联素释放和焦虑样障碍
Fengzhen Yang,Yajie Wang,Xiao Wang et al.
Fengzhen Yang et al.
Exercise training can prevent anxiety disorders in both rodent models and human cohorts. The involvement of peripheral factors in exercise-mediated mental health is being appreciated. It is recently shown that the hepatic biosynthesis of li...
Emerging Roles of Plant-Derived Extracellular Vesicles in Biotherapeutics: Advances, Applications, and Future Perspectives [0.03%]
植物来源外泌体在生物治疗中的新兴作用：进展、应用和未来展望
Cheng Li,Aoqiong Zeng,Li Li et al.
Cheng Li et al.
Extracellular vesicles (EVs) are nanoscale luminal vesicles, which play an important role in intercellular communication through surface signaling and molecular cargo delivery (proteins, lipids, nucleic acids, etc.). Recently, plant-derived...
Nanomaterials-Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis [0.03%]
用于骨质疏松症治疗的基于纳米材料的药物递送系统
Donghong Shi,Yuling Li,Meng Tian et al.
Donghong Shi et al.
The etiology of osteoporosis is rooted in the disruption of the intricate equilibrium between bone formation and bone resorption processes. Nevertheless, the conventional anti-osteoporotic medications and hormonal therapeutic regimens curre...
Electroacupuncture's Impact on the Hippocampal RAGE/LRP1 Receptor System in SAMP8 Mice [0.03%]
电针调节SAMR8鼠海马RAGE/清道夫受体系统的作用机制研究
Zhitao Hou,Jindi Ma,Xian Zhang et al.
Zhitao Hou et al.
Age-related cognitive impairment (ARCI) is linked to β-amyloid (Aβ) accumulation and disrupted blood-brain barrier (BBB) transport via receptors for advanced glycation end products (RAGE) and low-density lipoprotein receptor-related prote...
Toward Design Principles for Biomolecular Condensates for Metabolic Pathways [0.03%]
面向代谢途径生物分子凝聚体的设计原则
Alain A M André,Nikita Rehnberg,Ankush Garg et al.
Alain A M André et al.
Biology uses membrane-less organelles or biomolecular condensates as dynamic reaction compartments that can form or dissolve to regulate biochemical pathways. This has led to a flurry of research aiming to design new synthetic organelles th...
Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications [0.03%]
利用机器人技术和机器学习扩大合成细胞生产以用于治疗应用
Noga Sharf-Pauker,Ido Galil,Omer Kfir et al.
Noga Sharf-Pauker et al.
Synthetic cells (SCs), developed through bottom-up synthetic biology, hold great potential for biomedical applications, with the promise of replacing malfunctioning natural cells and treating diseases with spatiotemporal control. Currently,...
Ameliorating TIMM50 Loss Slows Senescence by Improving Mitochondrial Structure and Function [0.03%]
改善TIMM50的损失通过提高线粒体的结构和功能来减缓细胞衰老
Amrita Nepalia,Deepak Kumar Saini
Amrita Nepalia
Mitochondrial dysfunction is an irrefutable hallmark of cellular senescence and aging. The dysfunction is marked by increased mitochondrial volume and reduced function, typified by low Adenosine Triphosphate (ATP) production and higher Reac...
IER3 Facilitates Tumor Progression and Aberrant Glycolysis via Activating wnt/β-Catenin Pathway in Oral Squamous Cell Carcinoma [0.03%]
在口腔鳞状细胞癌中IER3通过激活wnt/β-catenin通路促进肿瘤进程和异常糖酵解
Changwei Yin,Yi Miao,Wei Lu et al.
Changwei Yin et al.
The function and molecular biological mechanism of immediate early response 3 (IER3) on the tumorigenesis of oral squamous cell carcinoma (OSCC) are aimed to be explored. The effects of IER3 on the proliferation, apoptosis, and mobility of ...