Integrative Analysis of PAIP2B to Identify a Novel Biomarker for Pancreatic Ductal Adenocarcinoma [0.03%]
PAIP2B的综合分析鉴定出一种新型胰腺导管腺癌生物标志物
Yaoxian Xiang,Li Wang,Yurong Cheng et al.
Yaoxian Xiang et al.
The aim of the study was to evaluate the potential diagnostic and prognostic value of gene, Poly A-Binding Protein Interacting Protein 2B ( PAIP2B ) in pancreatic cancer. We used the gene expression data and clinical information of pancreat...
Oluwatosin Debola Oyebode,Pınar Tulay
Oluwatosin Debola Oyebode
Alzheimer's disease (AD) is a neurodegenerative disorder that advances gradually and primarily impacts the hippocampus region of the brain. It is defined by a deterioration in cognitive function as well as an observable loss of memory reten...
Screening for Mutations in Hereditary Cancer Susceptibility Genes in a Region with High Endogamy in Brazil [0.03%]
在巴西一个高内婚率地区对遗传性癌症易感基因突变进行筛选研究
Polyanna Oliveira,Paula Correa,Angelina Acosta et al.
Polyanna Oliveira et al.
Introduction Cancer is a multifactorial disease dependent on the influence of genetic and environmental factors. About 10% of cancers are associated with germline mutations, which predispose to a higher risk of developing cancer. Currently,...
Severe Unilateral Microtia with Aural Atresia, Hair White Patch, Stereotypes in a Young Boy with De novo 16p13.11 Deletion: Reasons for a New Genotype-Phenotype Correlation [0.03%]
伴有耳前庭发育不全、白发斑和刻板行为的单侧小耳畸形的新基因型表型相关性原因——带有de novo 16p13. 11缺失的年轻男孩一例报告
Piero Pavone,Xena Giada Pappalardo,Claudia Parano et al.
Piero Pavone et al.
Background Microtia is an uncommon congenital malformation ranging from mild anatomic structural abnormalities to partial or complete absence of the ear leading to hearing impairment. Congenital microtia may present as a single malformation...
Study on Screening Core Biomarkers of Noise and Drug-Induced Hearing Loss Based on Transcriptomics [0.03%]
基于转录组学的噪声及药物诱发听力损失核心生物标志物筛选研究
Xin Qiu,Qing-Qing Jiang,Wei-Wei Guo et al.
Xin Qiu et al.
Background Noise and drug-induced hearing loss (HL) is becoming more and more serious, but the integration and analysis based on transcriptomics and proteomics are lacking. On the one hand, this study aims to integrate existing public trans...
Spleen-Derived CCL9 Recruits MDSC to Facilitate Tumor Growth in Orthotopic Hepatoma Mice [0.03%]
脾脏衍生的CCL9募集MDSC以促进肝癌异种移植小鼠肿瘤生长
Baohua Li,Wenjuan Li,Yingxue Liang et al.
Baohua Li et al.
Objectives Spleen is involved in multiple diseases, the role of the spleen and spleen-derived factors in hepatocellular carcinoma (HCC) is still not clarified. Methods In the current study, a murine H22 orthotopic hepatoma model was establi...
Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins [0.03%]
脑膜炎球菌B因子H结合蛋白与人蛋白质的分子模拟关系研究
Darja Kanduc
Darja Kanduc
This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on en...
Severe Hypernatremia as Presentation of Netherton Syndrome [0.03%]
ネトरートン症候群の首发表现となる严重高钠血症病例报告及文献复习——难治性失水和肾脏机能障碍
A Di Nora,M C Consentino,G Messina et al.
A Di Nora et al.
Netherton syndrome is a rare, multisystem, autosomal recessive genodermatosis characterized by a triad of manifestations: congenital ichthyosis, immune dysregulation, and scalp anomalies. We report the case of a 1-month-old male infant eval...
Unraveling FOXO3a and USP18 Functions in Idiopathic Pulmonary Fibrosis through Single-Cell RNA Sequencing of Mouse and Human Lungs [0.03%]
通过小鼠和人类肺单细胞RNA测序解析FOXO3a和USP18在特发性肺纤维化中的作用
Ban Wang,Jichun Pan,Zhonghui Liu
Ban Wang
Background Idiopathic pulmonary fibrosis (IPF) is identified as a chronic, progressive lung disease, predominantly marked by enhanced fibroblast proliferation and excessive deposition of extracellular matrix. The intricate interactions betw...
The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review [0.03%]
结直肠癌信号通路中微小核糖核酸的临床意义：综述
Athanasios Michas,Vasileios Michas,Evangelos Anagnostou et al.
Athanasios Michas et al.
Colorectal carcinoma (colon and rectum) is currently considered among the most prevalent malignancies of Western societies. The pathogenesis and etiological mechanisms underlying colorectal cancer (CRC) development remain complex and hetero...