Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation [0.03%]
通过两样本孟德尔随机化和生物信息学方法研究克罗恩病患者中核心基因-肠道菌群的关联
Wende Hao,Zhenjun Wang,Huachong Ma
Wende Hao
Background: Previous studies have suggested a potential link between the gut microbiota and diverticulitis. However, the causal relationships as well as underlying mechanisms remain unclear. ...
Generating a database by calculating the pathogenic variants and allele frequencies detected in hereditary cancers using genomic data: A nation study [0.03%]
基于国人基因组数据计算遗传性肿瘤致病突变及等位基因频率建立数据库：全国范围的研究
Manal Salah Babiker Ali,Polat Olgun,Ömer Diker et al.
Manal Salah Babiker Ali et al.
Background: Hereditary cancers are the consequence of inherited genetic variants that increase the risk of cancer development. The susceptibility to hereditary cancers can be increased by a combination of variable genes w...
The role of small extracellular vesicles in post-traumatic stress disorder [0.03%]
小型细胞外囊泡在创伤后应激障碍中的作用
Haixin Zhang,Qile Zhang,Shicheng Li et al.
Haixin Zhang et al.
Post-Traumatic Stress Disorder (PTSD) represents a significant mental health challenge closely associated with the consequences of traumatic experiences. Recently, small extracellular vesicles (sEVs) have been recognized as vital elements i...
Gene frequency and distribution of human platelet antigen-1 to -6, -10, -15, and -21 of platelets donors in Wuhan, China [0.03%]
中国武汉地区供血者血小板HPA-1至-6、-10、-15和-21的基因频率及基因型分布研究
Zhen Qu,Wangxia Li,Yuanyan Zhu et al.
Zhen Qu et al.
Background: In this study, the frequency of human platelet antigen (HPA) alleles and genotypes of platelet donors in Wuhan was evaluated and differences in HPA distribution between Wuhan and other regions in China were co...
Clinical medication guidance for hypertension personalization through pharmacogenomic research and analysis [0.03%]
高血压临床用药指导的个体化研究与分析
Qian Ren,Shoulei Wang,Yansong Ren et al.
Qian Ren et al.
Objective: We investigated the distribution of polymorphisms in five hypertension-related drug-target genes including cytochrome P450 2C9*3 (CYP2C9 *3), angiotensin II receptor type 1(AGTR1) (1166 A>C), cytochrome P450 2D...
A review of the immunogenetics of Stevens-Johnson syndrome and toxic epidermal necrolysis [0.03%]
Stevens-Johnson综合征和中毒性表皮坏死松解症免疫遗传学的研究进展
Ayca Kocaaga,Mustafa Kocaaga
Ayca Kocaaga
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very rare dermatologic disorders characterized by extensive detachment of the epidermis. Although some drugs, infectious agents, HLA genes, malignancy and connective ti...
Mayer-Rokitansky-Küster-Hauser syndrome associated with 7q11.23 microduplication: A case report [0.03%]
与7q11.23微重复综合征相关的梅耶-罗基坦斯基-库斯特-豪泽尔综合征病例报告
Gabriela Corassa Rodrigues da Cunha,Vanessa Sodré de Souza,Marcus Von Zuben et al.
Gabriela Corassa Rodrigues da Cunha et al.
Introduction: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by the congenital absence of the uterus and vagina in females with 46, XX karyotype. The genetic etiology remains poorly understood. ...
Real-world prognostic factors for first-line EGFR-TKI efficacy in advanced NSCLC patients harboring EGFR 21 L858R mutation [0.03%]
一线EGFR-TKI治疗晚期NSCLC患者的不同EGFR 21号L858R突变的预后因素分析
Yan&#x;e Liu,Lu Chen,Xin Zhu et al.
Yan&#x;e Liu et al.
Objective: This study aimed to investigate the prognostic factors for the treatment efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) patients with E...
Significant PK variability of plasma-derived FIX concentrates in chinese children with Haemophilia B: A fixed single-dose study of factor IX-CTBB [0.03%]
血友病B儿童血浆衍生FIX浓缩物的重要PK差异性：Factor IX-CTBB的固定单次剂量研究
Guoqing Liu,Di Ai,Gang Li et al.
Guoqing Liu et al.
Background: The pharmacokinetics (PK) characters of plasma-derived Factor IX (pdFIX) concentrate in Chinese children with Haemophilia B(HB) have not yet been reported. ...
Genetic contributions to the stability and satisfaction in Sexual Relationships [0.03%]
遗传因素对性关系的稳定性和满意度的影响
Kirolos Eskandar
Kirolos Eskandar
The stability and satisfaction of sexual relationships are critical determinants of individual well-being and societal cohesion. While much is known about the psychological and social factors influencing these outcomes, the genetic underpin...