Genomic Landscape Features of Minimally Invasive Adenocarcinoma and Invasive Lung Adenocarcinoma [0.03%]
微创肺腺癌和侵袭性肺腺癌的基因组特征
Wei Zhang,Hui Xu,Ning Tang et al.
Wei Zhang et al.
Background The widespread implementation of computed tomography has significantly increased the detection of small pulmonary nodules, including atypical adenomatous hyperplasia, minimally invasive adenocarcinoma (MIA), and invasive adenocar...
The Role of CRISPR/Cas9 in Revolutionizing Duchenne's Muscular Dystrophy Treatment: Opportunities and Obstacles [0.03%]
CRISPR/Cas9在革命化杜氏肌营养不良治疗中的作用：机遇与挑战
Ahsan Ali,Md Yakeen Rahman,Danish Sheikh
Ahsan Ali
Duchenne's muscular dystrophy (DMD) is a severe X-linked disorder characterized by progressive muscle degeneration, leading to loss of ambulation, respiratory failure, and premature death. It affects approximately 1 in 3,500 live male birth...
Mechanism of Genome Editing Tools and Their Application on Genetic Inheritance Disorders [0.03%]
基因编辑工具的作用机理及其在遗传性疾病中的应用
Dae Hwan Oh
Dae Hwan Oh
In the fields of medicine and bioscience, gene editing is increasingly recognized as a promising therapeutic approach for treating pathogenic variants in humans and other living organisms. With advancements in technology and knowledge, it i...
Eiman Meer
Eiman Meer
Microglia are immunocompetent cells that are present in the retina and central nervous system, and are involved in the development maintenance and immune functions in these systems. Developing from yolk sac-primitive macrophages, they proli...
Dipti Baskar,Seena Vengalil,Kiran Polavarapu et al.
Dipti Baskar et al.
Introduction ORAI-1 is a plasma membrane calcium release-activated calcium channel that plays a crucial role in the excitation-contraction of skeletal muscles. Loss-of-function mutations of ORAI-1 cause severe combined immunodeficiency, non...
Potential Mechanism and Perspectives of Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Review [0.03%]
间充质干细胞治疗缺血性卒中的潜在机制和展望：综述文章
Pengcheng Zhu,Hongtu Tan,Haobo Gao et al.
Pengcheng Zhu et al.
Mesenchymal stem cells (MSCs), as a stem cell type with multiple differentiation potentials and immune regulatory abilities, have shown broad prospects in the treatment of ischemic stroke in recent years. The main characteristics of MSCs in...
Zahra Rafiei Atani,Sareh Sadat Hosseini,Hossein Goudarzi et al.
Zahra Rafiei Atani et al.
Some human cancers worldwide may be related to human tumor viruses. Knowing, controlling, and managing the viruses that cause cancers remain a problem. Also, tumor viruses use ubiquitin-proteasome system (UPS) that can alter host cellular p...
Genetically Predicted Iron Status Is a Causal Risk of Rheumatoid Arthritis: A Mendelian Randomization Study [0.03%]
基因预测的铁状态是类风湿性关节炎的风险因素：孟德尔随机化研究
Boyuan Wu
Boyuan Wu
Background Current knowledge on iron's role in rheumatoid arthritis (RA) development is very limited, with studies yielding inconsistent findings. We conducted a two-sample Mendelian randomization study to assess the associations of iron st...
16S rRNA Sequencing Reveals Alterations of Gut Bacteria in Hirschsprung-Associated Enterocolitis [0.03%]
基于16S rRNA测序技术分析Hirschsprung病相关性小肠结肠炎患儿肠道菌群的改变
Hao Shi,Yong She,Wu Mao et al.
Hao Shi et al.
Hirschsprung-associated enterocolitis (HAEC) stands as most common and serious complication of Hirschsprung's disease. Variations in the microbiota composition may account for the differences observed between HAEC and healthy individuals, o...
Gene Mutations in Gastrointestinal Stromal Tumors: Advances in Treatment and Mechanism Research [0.03%]
胃肠间质瘤基因突变及其治疗和机制研究进展
Lei Cao,Wencong Tian,Yongjie Zhao et al.
Lei Cao et al.
Although gastrointestinal stromal tumors (GISTs) has been reported in patients of all ages, its diagnosis is more common in elders. The two most common types of mutation, receptor tyrosine kinase (KIT) and platelet-derived growth factor rec...