Clinical medication guidance for hypertension personalization through pharmacogenomic research and analysis [0.03%]
高血压临床用药指导的个体化研究与分析
Qian Ren,Shoulei Wang,Yansong Ren et al.
Qian Ren et al.
Objective: We investigated the distribution of polymorphisms in five hypertension-related drug-target genes including cytochrome P450 2C9*3 (CYP2C9 *3), angiotensin II receptor type 1(AGTR1) (1166 A>C), cytochrome P450 2D...
A review of the immunogenetics of Stevens-Johnson syndrome and toxic epidermal necrolysis [0.03%]
Stevens-Johnson综合征和中毒性表皮坏死松解症免疫遗传学的研究进展
Ayca Kocaaga,Mustafa Kocaaga
Ayca Kocaaga
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very rare dermatologic disorders characterized by extensive detachment of the epidermis. Although some drugs, infectious agents, HLA genes, malignancy and connective ti...
Mayer-Rokitansky-Küster-Hauser syndrome associated with 7q11.23 microduplication: A case report [0.03%]
与7q11.23微重复综合征相关的梅耶-罗基坦斯基-库斯特-豪泽尔综合征病例报告
Gabriela Corassa Rodrigues da Cunha,Vanessa Sodré de Souza,Marcus Von Zuben et al.
Gabriela Corassa Rodrigues da Cunha et al.
Introduction: Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is characterized by the congenital absence of the uterus and vagina in females with 46, XX karyotype. The genetic etiology remains poorly understood. ...
Real-world prognostic factors for first-line EGFR-TKI efficacy in advanced NSCLC patients harboring EGFR 21 L858R mutation [0.03%]
一线EGFR-TKI治疗晚期NSCLC患者的不同EGFR 21号L858R突变的预后因素分析
Yan&#x;e Liu,Lu Chen,Xin Zhu et al.
Yan&#x;e Liu et al.
Objective: This study aimed to investigate the prognostic factors for the treatment efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC) patients with E...
Significant PK variability of plasma-derived FIX concentrates in chinese children with Haemophilia B: A fixed single-dose study of factor IX-CTBB [0.03%]
血友病B儿童血浆衍生FIX浓缩物的重要PK差异性：Factor IX-CTBB的固定单次剂量研究
Guoqing Liu,Di Ai,Gang Li et al.
Guoqing Liu et al.
Background: The pharmacokinetics (PK) characters of plasma-derived Factor IX (pdFIX) concentrate in Chinese children with Haemophilia B(HB) have not yet been reported. ...
Genetic contributions to the stability and satisfaction in Sexual Relationships [0.03%]
遗传因素对性关系的稳定性和满意度的影响
Kirolos Eskandar
Kirolos Eskandar
The stability and satisfaction of sexual relationships are critical determinants of individual well-being and societal cohesion. While much is known about the psychological and social factors influencing these outcomes, the genetic underpin...
Anyou Wang
Anyou Wang
The mechanisms underlying the evolution of lifespan across organisms remain mysterious. This study computes multiple large datasets and reveals that noncoding RNAs (ncRNAs), rather than proteins, drive animal lifespan evolution. Species in ...
Exploring molecular mechanisms of drug resistance in bacteria and progressions in CRISPR/Cas9-based genome expurgation solutions [0.03%]
探索细菌的药物抗性分子机制及CRISPR/Cas9基因编辑技术的进展
K E Vivekanandan,P Vinoth Kumar,R C Jaysree et al.
K E Vivekanandan et al.
Antibiotic resistance in bacteria is a critical global health challenge, driven by molecular mechanisms such as genetic mutations, efflux pumps, enzymatic degradation of antibiotics, target site modifications, and biofilm formation. Horizon...
PROKR2 mutations and SPRY4 variants with uncertain significance in a Kallmann syndrome family: Incomplete penetrance [0.03%]
PROKR2突变和SPRY4基因意义未明的变异在一个科尔曼综合症家族中的研究：不完全贯穿困境
Yuanfan Yuan,Qianqian Huang,Jiehan Zhang et al.
Yuanfan Yuan et al.
Kallmann syndrome is a rare genetic disease characterized by the idiopathic hypogonadotropic hypogonadism with hyposmia or anosmia, which exhibits considerable heterogeneity in genotype and phenotype. Herein, we reported a 32-year-old male ...
Role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathogenesis of preeclampsia [0.03%]
血管紧张素II受体自身抗体(AT1-AA)在子痫前期发病机制中的作用研究
Jing Wang,Lijuan Shan,Yanhui Zhao et al.
Jing Wang et al.
Preeclampsia(PE) is the most prevalent complication during pregnancy and constitutes a significant cause of morbidity and mortality among pregnant women and their fetuses. Recent studies have demonstrated elevated levels of angiotensin II t...