Analysis of IL-6 and IL-1β Gene coding and study on specific clearance using histidine-grafted PVDF membranes [0.03%]
IL-6和IL-1β基因编码分析及组氨酸接枝PVDF膜的特异吸附研究
Ke Li,JuanJuan Liu,Kuo Zhang et al.
Ke Li et al.
Severely infected patients produce large amounts of inflammatory cytokines, such as interleukin-6 (IL-6) and interleukin-1β (IL-1β), leading to a "cytokine storm", which is a clinically refractory condition. Because IL-6 and IL-1β differ...
Hierarchical clustering defines hypermethylated RSPO2 as early-stage potential biomarker in colorectal cancer [0.03%]
层次聚类定义了RSPO2高甲基化作为结直肠癌早期潜在生物标志物
Ankit Srivastava,Gaurav Kant,Manish Pratap Singh et al.
Ankit Srivastava et al.
Background: Early-stage diagnosis, absence of specific reliable biomarkers, and better clinical management of colorectal cancer (CRC) remain major challenges. The Rspondin2 (RSPO2) gene is one of the most potent enablers ...
Machine learning approach to identify significant genes and classify cancer types from RNA-seq data [0.03%]
基于RNA序列数据的机器学习方法识别重要基因和分类癌症类型
Sultana Akter,Ridwan Olamilekan Adesola,Shreya Basnet
Sultana Akter
Cancer remains a leading cause of morbidity and mortality worldwide, with nearly 10 million deaths reported in 2022. In the United States, more than 618,000 deaths are projected to occur in 2025. Traditional methods for identifying cancer t...
Bioinformatics differential expression analysis of the effect of cannabidiol in chronic myeloid leukaemia cell line [0.03%]
大麻二酚对慢性髓系白血病细胞系作用的生物信息学差异表达分析
Petar P Donchev,Svetla T Danova
Petar P Donchev
Chronic myeloid leukaemia (CML) is the first clonal myeloproliferative disorder of pluripotent stem cells to be associated with a specific genetic abnormality, the Philadelphia chromosome, bearing the BCR-ABL1 fusion oncogene. Tyrosine kina...
Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation [0.03%]
通过单细胞RNA测序、eQTL孟德尔随机化和体外验证鉴定胃癌新型高风险基因
Li Qi,Haoyu Chen,Xinyu Hao et al.
Li Qi et al.
Background: Current targeted therapies for gastric cancer have limited efficacy, and recently discovered markers have not significantly improved survival rates in patients with gastric cancer. Therefore, it is imperative ...
Investigation of balanced chromosomal aberrations prevalence in healthy Turkish Cypriot couples [0.03%]
土耳其塞浦路斯健康夫妇平衡染色体异常的调查研究
Dize Deryali,Havva Cobanogullari,Mahmut Cerkez Ergoren
Dize Deryali
Chromosomal abnormalities play a significant role in reproductive issues and developmental disorders, yet information on their prevalence within the Turkish Cypriot population is limited. This study offers the first comprehensive cytogeneti...
A comprehensive comparison of third generation epidermal growth factor receptor tyrosine kinase inhibitors in the treatment efficacy and adverse events: A Bayesian meta-analysis [0.03%]
第三代表皮生长因子受体酪氨酸激酶抑制剂治疗效果和不良事件的全面比较：贝叶斯meta分析
Jinyu Yu,Hanyu Wu,Lu Yang et al.
Jinyu Yu et al.
Background: It is a challenge for clinicians to choose the optimal third generation EGFR-tyrosine kinase inhibitors (EGFR-TKIs) treatment for individual patients. In this meta-analysis we compare the efficacy of five thir...
Characterization of stem cell landscape and identification of stemness-related gene ENY2 in colorectal cancer by intergrated transcriptomic analysis [0.03%]
结直肠癌干细胞图谱的转录组解析及干性相关基因ENY2的鉴定
Wende Hao,Zhenjun Wang,Huachong Ma
Wende Hao
Background: Cancer stem cells (CSCs) drive colorectal cancer (CRC) progression, metastasis, and therapy resistance, but their heterogeneity limits targeted treatment efficacy. Clarifying the stemness landscape and underly...
Hemizygous contiguous gene deletion within Xq28 that includes BCAP31, ABCD1, SRPK3 and SSR4: case report and literature review [0.03%]
Xq28区包含BCAP31、ABCD1、SRPK3和SSR4的片段单体缺失：病例报告及文献复习
Joan Chern-Hui Lien,Vinay D Chandrasekaran,Tarachandra M Narumanchi et al.
Joan Chern-Hui Lien et al.
We report on a rare 110 kilobase contiguous gene deletion within chromosome region Xq28, encompassing 7 annotated Online Mendelian Inheritance in Man (OMIM) genes and extending from BCAP31 to the telomeric-located PDZD4. We review 13 other ...
Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation [0.03%]
通过两样本孟德尔随机化和生物信息学方法研究克罗恩病患者中核心基因-肠道菌群的关联
Wende Hao,Zhenjun Wang,Huachong Ma
Wende Hao
Background: Previous studies have suggested a potential link between the gut microbiota and diverticulitis. However, the causal relationships as well as underlying mechanisms remain unclear. ...