CD24 + MDSC-DCs Induced by CCL5-Deficiency Showed Improved Antitumor Activity as Tumor Vaccines [0.03%]
CCL5缺陷诱导的CD24+MDSC-DC肿瘤疫苗展示出更强的抗肿瘤活性
Lei Huang,Zequn Ding,Yan Zhang
Lei Huang
Background Dendritic cell (DC) tumor vaccine has been extensively utilized in preclinical and clinical studies; however, this technique has encountered many difficulties, particularly in late-stage tumor patients. For those, ex vivo-induced...
Ayca Kocaaga,Mustafa Kocaaga
Ayca Kocaaga
Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide a...
Evaluation of Utilizing the Distinct Genes as Predictive Biomarkers in Late-Onset Alzheimer's Disease [0.03%]
用于评估独特基因作为预测生物标志物在晚发性阿尔茨海默病中的作用
Sercan Kenanoglu,Nefise Kandemir,Hilal Akalin et al.
Sercan Kenanoglu et al.
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by a devastating decline in cognitive activities among all types of dementia, and it severely affects the quality of life. Late-onset AD (LOAD) occurs after the a...
Variant Curation is Crucial to Claim Digenic Inheritance in Juvenile Open Angle Glaucoma [0.03%]
青少年型原发性开角型青光眼双基因遗传说法需谨慎
Kok-Siong Poon,Karen Mei-Ling Tan
Kok-Siong Poon
Toe Walking as the Initial Symptom of a Spinocerebellar Ataxia 13 in a Patient Presenting with a Mutation in the KCNC3 Gene [0.03%]
以KCNC3基因突变为表现的脊小脑共济失调13例的最初症状为踮脚行走
David Pomarino,Johanna Ronja Thren,Anneke Thren et al.
David Pomarino et al.
This article at hand described a 4-year-old child patient who initially presented with the symptoms of toe walking. As part of the diagnostic process, the patient was genetically tested to find the cause of the gait anomaly. The genetic tes...
Emine Ikbal Atli,Engin Atli,Sinem Yalcintepe et al.
Emine Ikbal Atli et al.
Objective A significant number of genetic variations have been identified in chromosome 22, using molecular genetic techniques. Various genomic disorders on chromosome 22, including cat's eye syndrome caused by extra copies of the proximal ...
Disease Progression and Mutation Pattern in a Large Cohort of LGMD R1/LGMD 2A Patients from India [0.03%]
印度R1/LGMD 2A患者大样本队列中的疾病进展和突变模式
Valakunja H Ganaraja,Kiran Polavarapu,Mainak Bardhan et al.
Valakunja H Ganaraja et al.
Calpainopathy is caused by mutations in the CAPN3 . There is only one clinical and genetic study of CAPN3 from India and none from South India. A total of 72 (male[M]:female [F] = 34:38) genetically confirmed probands from 72 independent fa...
Investigation of Genetic Alterations in Congenital Heart Diseases in Prenatal Period [0.03%]
产前先天性心脏病的遗传学改变研究
Emine Ikbal Atli,Engin Atli,Sinem Yalcintepe et al.
Emine Ikbal Atli et al.
The prenatal diagnosis of congenital heart disease (CHD) is important because of mortality risk. The onset of CHD varies, and depending on the malformation type, the risk of aneuploidy is changed. To identify possible genetic alterations in...
Aysel Kalayci Yigin,Mehmet Bugrahan Duz,Mehmet Seven
Aysel Kalayci Yigin
Background Cleidocranial dysplasia (CCD, #MIM119600) is an autosomal-dominant skeletal dysplasia characterized by delayed closure of the cranial sutures, aplasia, or hypoplasia of the clavicles and dental abnormalities. These findings were ...