Role of Molecular Targeted Therapeutic Drugs in Treatment of Oral Squamous Cell Carcinoma: Development and Current Strategies-A Review Article [0.03%]
分子靶向治疗药物在口腔鳞癌治疗中的作用：发展现状及策略-综述文章
Himanshu Singh,Vedant Patel
Himanshu Singh
Because of active advancement in the field of biomedicine, people have in-depth knowledge of biological nature of malignant tumors and are able to recognized the overexpression of different molecules such as vascular endothelial growth fact...
The Role of Codon Usage, tRNA Availability, and Cell Proliferation in EBV Latency and (Re)Activation [0.03%]
EB病毒潜伏与(再)活化中密码子使用、tRNA可用性和细胞增殖的作用
Darja Kanduc
Darja Kanduc
Epstein-Barr nuclear antigen 1 (EBNA1) protein synthesis is inhibited during Epstein-Barr virus (EBV) latency and is resumed in EBV (re)activation. In analyzing the molecular mechanisms underpinning the translation of EBNA1 in the human hos...
A Narrative Review on Fanconi Anemia: Genetic and Diagnostic Considerations [0.03%]
泛血管瘤病的叙事性回顾：基因和诊断考量
Preksha Sharma,Neha Sharma,Dhruva Sharma
Preksha Sharma
Fanconi anemia (FA) is an autosomal recessive disorder, both genetically and phenotypically. It is characterized by chromosomal instability, progressive bone marrow failure, susceptibility to cancer, and various other congenital abnormaliti...
Investigation on the Effects of Modifying Genes on the Spinal Muscular Atrophy Phenotype [0.03%]
关于研究基因修饰对脊髓性肌肉萎缩表型的影响调查研究
Drenushe Zhuri,Hakan Gurkan,Damla Eker et al.
Drenushe Zhuri et al.
Introduction Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by the degeneration of motor neurons, muscle weakness, and atrophy that leads to infant's death. The duplication of exon 7/8 in the SMN2 gene...
Alessandra Di Nora,Greta De Costa,Alessia Di Mari et al.
Alessandra Di Nora et al.
Diagnosis in children with physical and intellective anomalies is very challenging because of the wide spectrum of causes. Array-based comparative genomic hybridization (CGH) has acquired an important role in pediatric diagnostic work up. I...
Investigating the Genetic Etiology of Pediatric Patients with Peripheral Hypotonia Using the Next-Generation Sequencing Method [0.03%]
采用高通量测序方法探索外周肌张力低下儿童患者的遗传病因
Damla Eker,Hakan Gurkan,Yasemin Karal et al.
Damla Eker et al.
Background Hypotonia occurs as a result of neurological dysfunction in the brain, brainstem, spinal cord, motor neurons, anterior horn cells, peripheral nerves, and muscles. Although the genotype-phenotype correlation can be established in ...
SARS-CoV-2-Induced Immunosuppression: A Molecular Mimicry Syndrome [0.03%]
SARS-CoV-2诱导的免疫抑制：一种分子模拟综合征
Darja Kanduc
Darja Kanduc
Background Contrary to immunological expectations, decay of adaptive responses against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) characterizes recovered patients compared with patients who had a severe disease course or d...
Role of PAX7 Gene rs766325 and rs4920520 Polymorphisms in the Etiology of Non-syndromic Cleft Lip and Palate: A Genetic Study [0.03%]
PAX7基因多态性在非综合征唇腭裂致病因素中的作用遗传学研究
Mahamad Irfanulla Khan,Prashanth Cs,Narasimhamurty Srinath
Mahamad Irfanulla Khan
Non-syndromic cleft lip and palate (NSCLP) is one of the most common birth defects in humans with an overall prevalence of ∼1 in 700 live births around the world. The etiology of NSCLP is complex involving multiple genes, environmental fac...
Pitfalls of PCR-RFLP in Detecting SARS-CoV-2 D614G Mutation [0.03%]
PCR-RFLP检测SARS-CoV-2 D614G突变的局限性分析
Kok-Siong Poon,Karen Mei-Ling Tan
Kok-Siong Poon
Mannose-Binding Lectin 2 Gene Polymorphism during Pandemic: COVID-19 Family [0.03%]
突发疫情期间的甘露聚糖结合凝集素2基因多态性：COVID-19家系研究
Tufan Tukek,Sacide Pehlivan,Yasemin Oyaci et al.
Tufan Tukek et al.
Mannose-binding lectin 2 (MBL2) is a serine protease which is believed to be an important factor in the inherited immune system. In this article, we present a coronavirus disease 2019 (COVID-19) family of five patients: a 56-year-old father...