PMS2 Pathogenic Variant in Lynch Syndrome-Associated Colorectal Cancer with Polyps [0.03%]
Lynch综合症相关息肉状结直肠癌中的PMS2致病变异体
Henriette Poaty,Lauria Batamba Bouya,Aimé Lumaka et al.
Henriette Poaty et al.
Background Lynch syndrome (LS) is an autosomal dominant condition due to the germline mutation in the mismatch repair (MMR) genes including MLH1 , MSH2 , MSH6, and PMS2 (post-meiotic segregation increased 2). The MMR mutation carriers have ...
Differentiation and Immunological Function of MDSC-Derived Dendritic Cells [0.03%]
MDSC来源的树突状细胞的分化及免疫功能
Zequn Ding,Yan Zhang
Zequn Ding
Dendritic cells (DCs) play a key role in initiating and regulating immune responses, and in addition to their roles in vivo, DCs are used as natural adjuvants for various tumor vaccines. In vitro, monocytes can be used to induce DCs, but in...
Zhiyuan Xie,Linghao Wang,Yan Zhang
Zhiyuan Xie
Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments because they mimic the structural and functional characteristics of organs. However, the full potential of organoids in research ha...
Jinjin Shao
Jinjin Shao
Exosomal microRNAs Targeting TP53 Gene as Promising Prognostic Markers for Head and Neck Squamous Cell Carcinoma [0.03%]
靶向TP53基因的exo-miRNA作为头颈部鳞状细胞癌预后的新标志物
Vijayashree Priyadharsini Jayaseelan,Paramasivam Arumugam
Vijayashree Priyadharsini Jayaseelan
Statement of Problem MicroRNAs are small non-coding RNAs that regulate an array of functions by targeting crucial genes. A significant dysregulation in the TP53 profile has been observed in the head and neck squamous cell carcinoma (HNSCC) ...
Epigenetic Alteration in Colorectal Cancer: A Biomarker for Diagnostic and Therapeutic Application [0.03%]
结直肠癌表观遗传改变的生物标志物诊断和治疗应用价值研究
Hafsa Yousif Solayman Essa,Gunay Kusaf,Ozel Yuruker et al.
Hafsa Yousif Solayman Essa et al.
Colorectal cancer (CRC) is the leading cause of cancer death worldwide. A crucial process that initiates and progresses CRC is various epigenetic and genetic changes occurring in colon epithelial cells. Recently, huge progress has been made...
Designing In-House SARS-CoV-2 RT-qPCR Assay for Variant of Concerns [0.03%]
针对关注变异株的新型冠状病毒RT-qPCR检测试剂盒的设计与发展
Mahmut Cerkez Ergoren,Gulten Tuncel,Cenk Serhan Ozverel et al.
Mahmut Cerkez Ergoren et al.
Variants (Alfa, Gamma, Beta, and Delta) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are circulating worldwide. These variants of concerns share some common mutations but they also have distinguishing mutations. These mut...
Dihydropyridine Reductase Deficiency: Acute Encephalopathy Related to Folinic Acid Treatment Interruption in a Girl [0.03%]
二氢叶酸还原酶缺乏症：一名女孩因叶酸治疗中断引起的急性脑病
Maria Grazia Pappalardo,Alessandra Di Nora,Andrea Giugno et al.
Maria Grazia Pappalardo et al.
We reported the case of acute encephalopathy related to colonic acid treatment interruption in a 12-year-old female child presenting to our unit with episodes of vomiting, headache, irritability, acute confusional state, seizures, and left ...