Exosomal microRNAs Targeting TP53 Gene as Promising Prognostic Markers for Head and Neck Squamous Cell Carcinoma [0.03%]
靶向TP53基因的exo-miRNA作为头颈部鳞状细胞癌预后的新标志物
Vijayashree Priyadharsini Jayaseelan,Paramasivam Arumugam
Vijayashree Priyadharsini Jayaseelan
Statement of Problem MicroRNAs are small non-coding RNAs that regulate an array of functions by targeting crucial genes. A significant dysregulation in the TP53 profile has been observed in the head and neck squamous cell carcinoma (HNSCC) ...
Epigenetic Alteration in Colorectal Cancer: A Biomarker for Diagnostic and Therapeutic Application [0.03%]
结直肠癌表观遗传改变的生物标志物诊断和治疗应用价值研究
Hafsa Yousif Solayman Essa,Gunay Kusaf,Ozel Yuruker et al.
Hafsa Yousif Solayman Essa et al.
Colorectal cancer (CRC) is the leading cause of cancer death worldwide. A crucial process that initiates and progresses CRC is various epigenetic and genetic changes occurring in colon epithelial cells. Recently, huge progress has been made...
Designing In-House SARS-CoV-2 RT-qPCR Assay for Variant of Concerns [0.03%]
针对关注变异株的新型冠状病毒RT-qPCR检测试剂盒的设计与发展
Mahmut Cerkez Ergoren,Gulten Tuncel,Cenk Serhan Ozverel et al.
Mahmut Cerkez Ergoren et al.
Variants (Alfa, Gamma, Beta, and Delta) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are circulating worldwide. These variants of concerns share some common mutations but they also have distinguishing mutations. These mut...
Dihydropyridine Reductase Deficiency: Acute Encephalopathy Related to Folinic Acid Treatment Interruption in a Girl [0.03%]
二氢叶酸还原酶缺乏症：一名女孩因叶酸治疗中断引起的急性脑病
Maria Grazia Pappalardo,Alessandra Di Nora,Andrea Giugno et al.
Maria Grazia Pappalardo et al.
We reported the case of acute encephalopathy related to colonic acid treatment interruption in a 12-year-old female child presenting to our unit with episodes of vomiting, headache, irritability, acute confusional state, seizures, and left ...
Role of Molecular Targeted Therapeutic Drugs in Treatment of Oral Squamous Cell Carcinoma: Development and Current Strategies-A Review Article [0.03%]
分子靶向治疗药物在口腔鳞癌治疗中的作用：发展现状及策略-综述文章
Himanshu Singh,Vedant Patel
Himanshu Singh
Because of active advancement in the field of biomedicine, people have in-depth knowledge of biological nature of malignant tumors and are able to recognized the overexpression of different molecules such as vascular endothelial growth fact...
The Role of Codon Usage, tRNA Availability, and Cell Proliferation in EBV Latency and (Re)Activation [0.03%]
EB病毒潜伏与(再)活化中密码子使用、tRNA可用性和细胞增殖的作用
Darja Kanduc
Darja Kanduc
Epstein-Barr nuclear antigen 1 (EBNA1) protein synthesis is inhibited during Epstein-Barr virus (EBV) latency and is resumed in EBV (re)activation. In analyzing the molecular mechanisms underpinning the translation of EBNA1 in the human hos...
A Narrative Review on Fanconi Anemia: Genetic and Diagnostic Considerations [0.03%]
泛血管瘤病的叙事性回顾：基因和诊断考量
Preksha Sharma,Neha Sharma,Dhruva Sharma
Preksha Sharma
Fanconi anemia (FA) is an autosomal recessive disorder, both genetically and phenotypically. It is characterized by chromosomal instability, progressive bone marrow failure, susceptibility to cancer, and various other congenital abnormaliti...
Investigation on the Effects of Modifying Genes on the Spinal Muscular Atrophy Phenotype [0.03%]
关于研究基因修饰对脊髓性肌肉萎缩表型的影响调查研究
Drenushe Zhuri,Hakan Gurkan,Damla Eker et al.
Drenushe Zhuri et al.
Introduction Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by the degeneration of motor neurons, muscle weakness, and atrophy that leads to infant's death. The duplication of exon 7/8 in the SMN2 gene...
Alessandra Di Nora,Greta De Costa,Alessia Di Mari et al.
Alessandra Di Nora et al.
Diagnosis in children with physical and intellective anomalies is very challenging because of the wide spectrum of causes. Array-based comparative genomic hybridization (CGH) has acquired an important role in pediatric diagnostic work up. I...
Investigating the Genetic Etiology of Pediatric Patients with Peripheral Hypotonia Using the Next-Generation Sequencing Method [0.03%]
采用高通量测序方法探索外周肌张力低下儿童患者的遗传病因
Damla Eker,Hakan Gurkan,Yasemin Karal et al.
Damla Eker et al.
Background Hypotonia occurs as a result of neurological dysfunction in the brain, brainstem, spinal cord, motor neurons, anterior horn cells, peripheral nerves, and muscles. Although the genotype-phenotype correlation can be established in ...