Efficacy and Safety Analysis of Combination Therapy Consisting of Intravenous Immunoglobulin and Corticosteroids versus Respective Monotherapies in the Treatment of Relapsed ITP in Adults [0.03%]
成人ITP复发患者免疫球蛋白与糖皮质激素联合治疗疗效及安全性的 meta 分析
Lijun Fang,Jing Sun,Yongqiang Zhao et al.
Lijun Fang et al.
Objective In this study, we aimed to evaluate the efficacy and safety of combination therapy, consisting of intravenous immunoglobulin (IVIg) and corticosteroids, in comparison to respective monotherapies in the treatment of relapsed immune...
Enabling Real-World Data to Accelerate the Development of Innovative Cancer Biomarkers [0.03%]
释放真实世界数据在创新癌症生物标志物开发中的潜能
Chen Yeh
Chen Yeh
The molecular diagnostics industry has historically relied on sanitized clinical trials and commoditized data sources to inform its biomarker discovery and validation process-an under-substantiated approach that was ultra-expensive, resourc...
Darja Kanduc
Darja Kanduc
Background and Aim Immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in newborns and children after prophylactic immunization is currently a relevant research topic. The present study analyzes the issue by...
NGS-Panel Diagnosis Developed for the Differential Diagnosis of Idiopathic Toe Walking and Its Application for the Investigation of Possible Genetic Causes for the Gait Anomaly [0.03%]
用于特发性踮脚走路的鉴别诊断的下一代测序（NGS）基因检测开发及其在研究步态异常的可能遗传原因方面的应用
David Pomarino,Anna Emelina,Jens Heidrich et al.
David Pomarino et al.
Idiopathic toe walking (ITW) describes a condition affecting approximately 4.5% of children. Toe walking is an accompanying symptom for many hereditary disorders. This retrospective study uses next-generation sequencing-panel-diagnosis to i...
Replication Timing Aberration of KIF14 and MDM4 / PI3KC 2 β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients [0.03%]
KIF14和MDM4/PI3KC2β等位基因的复制时间异常及染色体不稳定性和治疗反应不佳的标记物在尤因肉瘤患者中的作用
Fernanda Rocha Rojas Ayala,Jeffrey William Martin,Carmen Silvia Bertuzzo
Fernanda Rocha Rojas Ayala
Replication timing of allelic gene pairs is strictly regulated according to expression, genome stability, and epigenetic changes, and tumorigenesis may be associated with changes in the allelic replication in various tumors. Our aim was to ...
Role of Molecular Targeted Therapeutic Drugs in Treatment of Glioblastoma: A Review Article [0.03%]
分子靶向药物治疗胶质母细胞瘤的研究进展：综述文章
Himanshu Singh
Himanshu Singh
Glioblastoma is remarkably periodic primary brain tumor, characterizing an eminently heterogeneous pattern of neoplasms that are utmost destructive and threatening cancers. An enhanced and upgraded knowledge of the various molecular pathway...
The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review [0.03%]
基质金属蛋白酶9基因在肿瘤发生和转移中的作用：综述文章
Datis Kalali
Datis Kalali
Matrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial d...
Genetic Analysis of the Single-Nucleotide Polymorphisms rs880810, rs545793, rs80094639, and rs13251901 in Nonsyndromic Oral Clefts: A Case-Parent Trio Study [0.03%]
非综合征性唇裂和腭裂遗传分析：病例-父母 trio 研究评估单核苷酸多态性标记位点(rs880810、rs545793、rs80094639 和 rs13251901)
Mahamad Irfanulla Khan,Prashanth Cs,N Srinath et al.
Mahamad Irfanulla Khan et al.
Oral clefts, including cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), are the most common types of congenital anomalies of the human face. Various genetic and environmental factors play a role in developing oral clefts. ...
Identification of a de novo Mutation in TMEM106B in a Saudi Child Causes Hypomyelination Leukodystrophy [0.03%]
TMEM106B的新发突变导致发育和进行性神经系统疾病：对一位沙特阿拉伯患儿的鉴定与研究
Lena Alotaibi,Amal Alqasmi
Lena Alotaibi
Hypomyelinating leukodystrophies are one of the white matter disorders caused by a lack of myelin deposition in the central nervous system (CNS). Here, we report the first case of hypomyelinating leukodystrophy in the Middle East and Saudi ...
Strong Association between Vitamin D Receptor Gene and Severe Acute Respiratory Syndrome coronavirus 2 Infectious Variants [0.03%]
维生素D受体基因与严重急性呼吸综合征冠状病毒2型感染变异株之间的强关联性
Begimai Mamurova,Gokce Akan,Evren Mogol et al.
Begimai Mamurova et al.
A coronavirus disease 2019 (COVID-19) disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created significant concern since December 2019 worldwide. The virus is known to be highly transmissible. Heterog...