Study on Screening Core Biomarkers of Noise and Drug-Induced Hearing Loss Based on Transcriptomics [0.03%]
基于转录组学的噪声及药物诱发听力损失核心生物标志物筛选研究
Xin Qiu,Qing-Qing Jiang,Wei-Wei Guo et al.
Xin Qiu et al.
Background Noise and drug-induced hearing loss (HL) is becoming more and more serious, but the integration and analysis based on transcriptomics and proteomics are lacking. On the one hand, this study aims to integrate existing public trans...
Spleen-Derived CCL9 Recruits MDSC to Facilitate Tumor Growth in Orthotopic Hepatoma Mice [0.03%]
脾脏衍生的CCL9募集MDSC以促进肝癌异种移植小鼠肿瘤生长
Baohua Li,Wenjuan Li,Yingxue Liang et al.
Baohua Li et al.
Objectives Spleen is involved in multiple diseases, the role of the spleen and spleen-derived factors in hepatocellular carcinoma (HCC) is still not clarified. Methods In the current study, a murine H22 orthotopic hepatoma model was establi...
Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins [0.03%]
脑膜炎球菌B因子H结合蛋白与人蛋白质的分子模拟关系研究
Darja Kanduc
Darja Kanduc
This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on en...
Severe Hypernatremia as Presentation of Netherton Syndrome [0.03%]
ネトरートン症候群の首发表现となる严重高钠血症病例报告及文献复习——难治性失水和肾脏机能障碍
A Di Nora,M C Consentino,G Messina et al.
A Di Nora et al.
Netherton syndrome is a rare, multisystem, autosomal recessive genodermatosis characterized by a triad of manifestations: congenital ichthyosis, immune dysregulation, and scalp anomalies. We report the case of a 1-month-old male infant eval...
Unraveling FOXO3a and USP18 Functions in Idiopathic Pulmonary Fibrosis through Single-Cell RNA Sequencing of Mouse and Human Lungs [0.03%]
通过小鼠和人类肺单细胞RNA测序解析FOXO3a和USP18在特发性肺纤维化中的作用
Ban Wang,Jichun Pan,Zhonghui Liu
Ban Wang
Background Idiopathic pulmonary fibrosis (IPF) is identified as a chronic, progressive lung disease, predominantly marked by enhanced fibroblast proliferation and excessive deposition of extracellular matrix. The intricate interactions betw...
The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review [0.03%]
结直肠癌信号通路中微小核糖核酸的临床意义：综述
Athanasios Michas,Vasileios Michas,Evangelos Anagnostou et al.
Athanasios Michas et al.
Colorectal carcinoma (colon and rectum) is currently considered among the most prevalent malignancies of Western societies. The pathogenesis and etiological mechanisms underlying colorectal cancer (CRC) development remain complex and hetero...
Genetics and Genomics of Chronic Pancreatitis with a Focus on Disease Biology and Molecular Pathogenesis [0.03%]
慢性胰腺炎的遗传学和基因组学：重点关注疾病生物学和分子发病机制
Erum Khan,Soura Chakrabarty,Sanobar Shariff et al.
Erum Khan et al.
Chronic pancreatitis is a long-term fibroinflammatory condition of the pancreas with varying incidences across countries. The recent increase in its occurrence implies the involvement of genetic, hereditary, and unconventional risk factors....
A Di Nora,G Pellino,A Di Mari et al.
A Di Nora et al.
In the clinical practice, it is not common for pediatricians to visit children with overgrowth phenotype. When it happens, it is important to focus on the age of manifestations and research the pathogenic causes using appropriate genetic te...
Mehran Radak,Hossein Fallahi
Mehran Radak
This review article discusses the epigenetic regulation of quiescent stem cells. Quiescent stem cells are a rare population of stem cells that remain in a state of cell cycle arrest until activated to proliferate and differentiate. The mole...
The Evaluation of Prognostic Value and Immune Characteristics of Ferroptosis-Related Genes in Lung Squamous Cell Carcinoma [0.03%]
铁死亡相关基因在肺鳞癌中的预后价值及免疫特征评估
Jialin Su,Shuhua Tan,Houwu Gong et al.
Jialin Su et al.
Background The purpose of our study was to construct a prognostic model based on ferroptosis-related gene signature to improve the prognosis prediction of lung squamous carcinoma (LUSC). Methods The mRNA expression profiles and clinical dat...