A Young Boy with 21q21.1 Microdeletion Showing Speech Delay, Spastic Diplegia, and MRI Abnormalities: Original Case Report [0.03%]
一项关于染色体21q21.1缺失综合征的病例报告：临床表型及父母平衡易位相关风险的遗传咨询分析
Piero Pavone,Raffaele Falsaperla,Martino Ruggieri et al.
Piero Pavone et al.
Chromosome 21q deletion syndrome is a rare disorder affecting the long arm of chromosome 21 and manifesting with wide phenotypic features depending on the size and position of the deleted region. In the syndrome, three distinct deleted regi...
Review: Advances in the Pathogenesis and Treatment of Immune Thrombocytopenia Associated with Viral Hepatitis [0.03%]
与病毒性肝炎相关的免疫性血小板减少症的发病机制和治疗进展评述
Yanmei Xu,Yunfei Chen,Lei Zhang
Yanmei Xu
Hepatitis B virus and hepatitis C virus are the hepatitis subtypes that most commonly induce immune thrombocytopenia (ITP). Although the pathogenesis of viral hepatitis-associated ITP remains unclear, it may involve antibody cross-reactivit...
Expression of CD44 in Head and Neck Squamous Cell Carcinoma-An In-Silico Study [0.03%]
头颈鳞状细胞癌中CD44的表达-一项计算机模拟研究
Loganathan Kavitha,Jayaseelan Vijayashree Priyadharsini,Deepthi Kattula et al.
Loganathan Kavitha et al.
Introduction CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers r...
Molecular Epidemiology of HCV RNA Genotype-3 in Dhaka City, Bangladesh [0.03%]
孟加拉国达卡城市抗丙型肝炎病毒rna基因3型的分子流行病学特征研究
Md Arifur Rahman,Md Monirul Islam,Md Eunus Ali et al.
Md Arifur Rahman et al.
Hepatitis C virus (HCV) is a causative agent that causes chronic liver diseases worldwide. It is a little, enclosed, single-stranded ribonucleic acid (RNA) virus. The recognition of the pathogenic HCV genotype is critical for the remedy of ...
Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies [0.03%]
菲塞汀抗肿瘤作用的机制与靶点研究及未来治疗展望
Eskandar Qaed,Bandar Al-Hamyari,Ahmed Al-Maamari et al.
Eskandar Qaed et al.
Background Cancer remains a critical global health challenge and a leading cause of mortality. Flavonoids found in fruits and vegetables have gained attention for their potential anti-cancer properties. Fisetin, abundantly present in strawb...
Identification of Plasma Thrombopoietin Level and Its Significance in Patients with Aplastic Anemia and Myelodysplastic Syndrome [0.03%]
血浆促血小板生成素水平的测定及其在再生障碍性贫血和骨髓增生异常综合征患者中的临床意义
Mengying Zhang,Gaochao Zhang,Fangfang Xu et al.
Mengying Zhang et al.
Objective Our objective was to investigate the concentration of plasma thrombopoietin (TPO) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS), as well as its relationship with patients' responses to recombined human T...
Molecular Evaluation of Joubert Syndrome and Hearing Impairment in a Patient with Ataxic Cerebral Palsy [0.03%]
乔布陈综合征和听力损伤的分子评价及共患病小脑性痴呆共济失调型脑瘫患者的分析
N Sreedevi,N Swapna,Santosh Maruthy et al.
N Sreedevi et al.
Joubert syndrome (JBTS) is a rare autosomal recessive or X-linked congenital brain malformation with strong genetic heterogeneity. Other neurological features of JBTS include hypotonia, ataxia, developmental delay, and cognitive impairment....
ADAR Expression and Single Nucleotide Variants in Multiple Sclerosis Patients Affect the Response to Interferon Beta Therapy [0.03%]
ADAR基因表达及单核苷酸变异影响多发性硬化患者对干扰素β治疗的反应
Fatemeh Fakhr,Vahid Shaygannejad,Mehdi Khorrami et al.
Fatemeh Fakhr et al.
Interferon (IFN)-β is the first-line disease management choice in multiple sclerosis (MS) with profound effects; however, in up to 50% of patients, clinical response does not occur. Ascertaining the responding state, need a long-term clini...
VEXAS Syndrome-Review [0.03%]
VEXAS综合征-综述
Yue Zhang,Xifeng Dong,Huaquan Wang
Yue Zhang
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined refractory adult-onset autoinflammatory syndrome caused by somatic mutations in the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene in hema...
IL-10 Polymorphism and Breast Cancer Risk in Georgian Women: A Case-Control Study [0.03%]
格鲁吉亚妇女中白细胞介素-10基因多态性与乳腺癌风险的病例对照研究
Saba Ahmadi,Sandro Surmava,Eka Kvaratskhelia et al.
Saba Ahmadi et al.
Background Interleukin-10 (IL-10) is a cytokine with a vast variety of functions, but its role in cancer development and progression is not yet clear. It is involved in two of the hallmarks of cancer: vascularization and immune modulation. ...