Multifunctional Nanocarriers-Mediated Synergistic Combination of Immune Checkpoint Inhibitor Cancer Immunotherapy and Interventional Oncology Therapy [0.03%]
多功能纳米载体介导的免疫检查点抑制剂癌症免疫疗法与介入放射学治疗的协同组合疗法
Bongseo Choi,Dong-Hyun Kim
Bongseo Choi
Immune checkpoint inhibitor (ICI) cancer immunotherapies are becoming one of the standard therapies for cancer patients. However, ICI cancer immunotherapy's overall response rate is still moderate and even combinational ICI cancer immunothe...
pH-EVD: A pH-Paper-Based Extraction and Visual Detection System for Instrument-Free SARS-CoV-2 Diagnostics [0.03%]
基于PH试纸的SARS-CoV-2诊断工具pH-EVD系统开发及应用研究
Xiong Ding,Ziyue Li,Lori Avery et al.
Xiong Ding et al.
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of deaths worldwide. However, most SARS-CoV-2 detection methods depend on time-consuming ...
Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective [0.03%]
声带再生生物材料的免疫学进展
Patrick T Coburn,Xuan Li,Jianyu Y Li et al.
Patrick T Coburn et al.
Vocal folds, housed in the upper respiratory tract, are important to daily breathing, speech and swallowing functions. Irreversible changes to the vocal fold mucosae, such as scarring and atrophy, require a regenerative medicine approach to...
Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina [0.03%]
视网膜神经元对刺激敏感性的形态因素
Vineeth Raghuram,Paul Werginz,Shelley I Fried et al.
Vineeth Raghuram et al.
Retinal prostheses are a promising therapeutic intervention for patients afflicted by outer retinal degenerative diseases like retinitis pigmentosa and age-related macular degeneration. While significant advances in the development of retin...
The biophysics of cancer: emerging insights from micro- and nanoscale tools [0.03%]
微纳米工具在癌症生物物理学中的应用及新见解
Peter E Beshay,Marcos G Cortes-Medina,Miles M Menyhert et al.
Peter E Beshay et al.
Cancer is a complex and dynamic disease that is aberrant both biologically and physically. There is growing appreciation that physical abnormalities with both cancer cells and their microenvironment that span multiple length scales are impo...
Extracellular Vesicles as Drug Delivery System for Treatment of Neurodegenerative Disorders: Optimization of the Cell Source [0.03%]
外泌体作为神经退行性疾病治疗的药物递送系统：细胞来源的优化
Matthew J Haney,Yuling Zhao,John K Fallon et al.
Matthew J Haney et al.
Extracellular vesicles (EVs) represent a next generation drug delivery system that combines nanoparticle size with extraordinary ability to cross biological barriers, reduced immunogenicity, and low offsite toxicity profiles. A successful a...
Elvan Dogan,Asli Kisim,Gizem Bati-Ayaz et al.
Elvan Dogan et al.
Microfluidic tumors-on-chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which...
A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine [0.03%]
心脏组织工程和再生医学中细胞外囊泡的新角色
Karl T Wagner,Milica Radisic
Karl T Wagner
Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane-b...
Esterase-activatable and GSH-responsive Triptolide Nano-prodrug for the Eradication of Pancreatic Cancer [0.03%]
厄他培非康纳米前药用于根除胰腺癌
Binglin Sui,Chen Cheng,Shanshan Shi et al.
Binglin Sui et al.
Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility and severe liver toxicity of T...
Pi-stacking Enhances Stability, Scalability of Formation, Control over Flexibility and Circulation Time of Polymeric Filaments [0.03%]
π堆积增强了聚合物丝的稳定性，形成可扩展性，控制了聚合物丝的柔韧性和循环时间
Sophia Li,Sharan Bobbala,Michael P Vincent et al.
Sophia Li et al.
Self-assembling filomicelles (FM) are of great interest to nanomedicine due to their structural flexibility, extensive systemic circulation time, and amenability to unique "cylinder-to-sphere" morphological transitions. However, current fab...