Nonviral Gold Nanoparticle-Mediated Delivery of CRISPR-Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells [0.03%]
非病毒金纳米颗粒介导CRISPR-Cas9核糖核蛋白和长DNA转基因转染到原代血细胞中
Rachel A Cunningham,Karthikeya S V Gottimukkala,Daniel D Lane et al.
Rachel A Cunningham et al.
Gene editing using CRISPR systems has gained traction for its potential to treat various diseases, but delivery remains a major challenge. We have previously reported an entirely synthetic gold nanoparticle formulation which can safely and ...
Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential [0.03%]
异质性模型揭示了胶质母细胞瘤对替莫唑胺耐药性的表型变化及迁移能力的变化
Victoria A Kriuchkovskaia,Ela K Eames,Sydney A McKee et al.
Victoria A Kriuchkovskaia et al.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with limited survival outcomes due to tumor recurrence, mainly driven by GBM cell invasion and therapy resistance. Although temozolomide (TMZ) rem...
Noninvasive Detection and Thermal Ablation Therapy of Endometriosis Using Silica-Coated Gold Nanorods [0.03%]
二氧化硅包被金纳米棒在子宫内膜异位症的非侵入式诊断及热消融治疗中的应用
Panangattukara Prabhakaran Praveen Kumar,Seock-Jin Chung,Kay Hadrick et al.
Panangattukara Prabhakaran Praveen Kumar et al.
Endometriosis (EM) is a gynecological disease where endometrial tissue grows outside the uterus. Current diagnostic methods are mainly through surgical visualization with histological verification; there's a need for noninvasive approaches....
Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production [0.03%]
连续液体界面生产生成的生物打印抗癌细胞治疗系统的特征分析
Lauren Kass,Ike Keku,Yu Zhang et al.
Lauren Kass et al.
Anticancer cell therapies have remarkable clinical potential yet fail to reach the clinic due to poor delivery. 3D bioprinting (3DBP) can be leveraged for generating cell therapy delivery devices, where the biomaterial system acts as a prot...
Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma [0.03%]
用于胶质母细胞瘤光动力学和光独立疗法的自组装Verteporfin纳米颗粒
John A Quinlan,Kaylin Baumiller,Anandita Gaur et al.
John A Quinlan et al.
Verteporfin (VP) has been used for photodynamic therapy (PDT) for over 20 years, and new applications have brought it back into the spotlight. VP is hydrophobic and requires lipid carriers for clinical delivery as Visudyne. A nanosuspension...
CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore [0.03%]
基于干细胞因子标记的荧光内镜成像技术在胃肠道间质瘤术中的应用研究
Shinsuke Nomura,Shinya Yokomizo,Zhidong Wang et al.
Shinsuke Nomura et al.
Complete resection without damaging the capsule is the gold-standard surgical approach for nonmetastatic gastrointestinal stromal tumors (GIST). However, accurately locating tumors during surgery is challenging because GIST is covered by no...
Long-Term Neural Recording Performance of PEDOT/CNT/Dexamethasone Coated Electrode Array Implanted in Visual Cortex of Rats [0.03%]
PEDOT/CNT/地塞米松涂覆电极阵列在大鼠视觉皮层的长期神经记录性能
Asiyeh Golabchi,Bingchen Wu,Zhanhong Jeff Du et al.
Asiyeh Golabchi et al.
Implantable neural electrode arrays can be inserted in the brain to provide single-cell electrophysiology recording for neuroscience research and brain-machine interface applications. However, maintaining signal quality over time is complic...
Long-Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection [0.03%]
长效循环纳米抗体对新型冠状病毒奥密克戎感染具有持久的预防作用
Geetha Jyothi Vaskuri,Gang Ye,Fan Bu et al.
Geetha Jyothi Vaskuri et al.
Breakthrough infections in vaccinated population and continuous emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants make it imperative to develop more efficacious medical countermeasures. Previously, an anti-S...
Evaluation of a Targeted Drug-Eluting Intravascular Nanotherapy to Prevent Neointimal Hyperplasia in an Atherosclerotic Rat Model [0.03%]
评估针对动脉粥样硬化 rat 模型内皮纳米治疗预防血管平滑肌细胞异位增生的效果
Emily R Newton,David C Gillis,Kui Sun et al.
Emily R Newton et al.
Objective: To test the hypothesis that nitric oxide-bearing collagen-targeted nanofibers will target vascular injury and inhibit neointimal hyperplasia in an atherosclerotic rat model. ...
Polymer design of microwell hydrogels influences epithelial-mesenchymal interactions during human bronchosphere formation [0.03%]
微波井水凝胶的聚合物设计可影响人支气管球形成的上皮-间质相互作用
Madeline K Eiken,Justin E Levine,Shinyeong Lee et al.
Madeline K Eiken et al.
Bronchospheres have emerged as a promising in vitro model towards probing questions on organ development and disease. Several organoid models, including from airway (e.g., bronchial, tracheal) cells, require 3D Matrigel, a complex mouse tum...