Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection-on-a-Chip Model [0.03%]
一种芯片感染模型中赖氨酰氧化酶通过减少绿脓杆菌诱导的中性粒细胞渗出发挥抗菌作用
Christopher J Calo,Tanvi Patil,Josephine Fouts et al.
Christopher J Calo et al.
Neutrophils are crucial players in the fight against infections. Unfortunately, dysregulated neutrophil function contributes to the pathogenesis of diseases, including cancer, fibrosis, and atherosclerosis, that leave those afflicted vulner...
Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine-Resistant Pancreatic Tumors [0.03%]
用于有效治疗吉西他滨耐药性胰腺肿瘤的可定制药物比例/载药量的介孔二氧化硅纳米粒子
Tamanna Binte Huq,Sudip Kumar Dam,Doaha Awad et al.
Tamanna Binte Huq et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival rate below 13% and limited treatment options due to rapid metastasis and pronounced chemoresistance. Gemcitabine (Gem) remains a first-line ch...
N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies [0.03%]
用于Tau病靶向治疗的N-氨基肽-石墨烯量子点负载小型细胞外囊泡
R Zhu,G Kim,Y Wang et al.
R Zhu et al.
Tauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of tau proteins into neurofibrillary tangles, driving synaptic dysfunction, neuronal loss, and disease progression through tau aggregate prop...
Nonviral Gold Nanoparticle-Mediated Delivery of CRISPR-Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells [0.03%]
非病毒金纳米颗粒介导CRISPR-Cas9核糖核蛋白和长DNA转基因转染到原代血细胞中
Rachel A Cunningham,Karthikeya S V Gottimukkala,Daniel D Lane et al.
Rachel A Cunningham et al.
Gene editing using CRISPR systems has gained traction for its potential to treat various diseases, but delivery remains a major challenge. We have previously reported an entirely synthetic gold nanoparticle formulation which can safely and ...
Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential [0.03%]
异质性模型揭示了胶质母细胞瘤对替莫唑胺耐药性的表型变化及迁移能力的变化
Victoria A Kriuchkovskaia,Ela K Eames,Sydney A McKee et al.
Victoria A Kriuchkovskaia et al.
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with limited survival outcomes due to tumor recurrence, mainly driven by GBM cell invasion and therapy resistance. Although temozolomide (TMZ) rem...
Noninvasive Detection and Thermal Ablation Therapy of Endometriosis Using Silica-Coated Gold Nanorods [0.03%]
二氧化硅包被金纳米棒在子宫内膜异位症的非侵入式诊断及热消融治疗中的应用
Panangattukara Prabhakaran Praveen Kumar,Seock-Jin Chung,Kay Hadrick et al.
Panangattukara Prabhakaran Praveen Kumar et al.
Endometriosis (EM) is a gynecological disease where endometrial tissue grows outside the uterus. Current diagnostic methods are mainly through surgical visualization with histological verification; there's a need for noninvasive approaches....
Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production [0.03%]
连续液体界面生产生成的生物打印抗癌细胞治疗系统的特征分析
Lauren Kass,Ike Keku,Yu Zhang et al.
Lauren Kass et al.
Anticancer cell therapies have remarkable clinical potential yet fail to reach the clinic due to poor delivery. 3D bioprinting (3DBP) can be leveraged for generating cell therapy delivery devices, where the biomaterial system acts as a prot...
Self-Assembled Verteporfin Nanoparticles for Photodynamic and Light-Independent Therapy in Glioblastoma [0.03%]
用于胶质母细胞瘤光动力学和光独立疗法的自组装Verteporfin纳米颗粒
John A Quinlan,Kaylin Baumiller,Anandita Gaur et al.
John A Quinlan et al.
Verteporfin (VP) has been used for photodynamic therapy (PDT) for over 20 years, and new applications have brought it back into the spotlight. VP is hydrophobic and requires lipid carriers for clinical delivery as Visudyne. A nanosuspension...
CD117-Targeted Intraoperative Imaging of Gastrointestinal Stromal Tumor Using a Stem-Cell-Factor-Labeled Fluorophore [0.03%]
基于干细胞因子标记的荧光内镜成像技术在胃肠道间质瘤术中的应用研究
Shinsuke Nomura,Shinya Yokomizo,Zhidong Wang et al.
Shinsuke Nomura et al.
Complete resection without damaging the capsule is the gold-standard surgical approach for nonmetastatic gastrointestinal stromal tumors (GIST). However, accurately locating tumors during surgery is challenging because GIST is covered by no...
Long-Term Neural Recording Performance of PEDOT/CNT/Dexamethasone Coated Electrode Array Implanted in Visual Cortex of Rats [0.03%]
PEDOT/CNT/地塞米松涂覆电极阵列在大鼠视觉皮层的长期神经记录性能
Asiyeh Golabchi,Bingchen Wu,Zhanhong Jeff Du et al.
Asiyeh Golabchi et al.
Implantable neural electrode arrays can be inserted in the brain to provide single-cell electrophysiology recording for neuroscience research and brain-machine interface applications. However, maintaining signal quality over time is complic...