Characterizing Lipid-Coated Mesoporous Silica Nanoparticles as CD169-Binding Delivery System for Rilpivirine and Cabotegravir [0.03%]
用于递送利匹韦林和卡博特格拉韦的长循环脂质涂覆介孔硅纳米粒及其特性研究
Han Zang,Josiane Fofana,Fangda Xu et al.
Han Zang et al.
Herein, lipid-coated mesoporous silica nanoparticles (LMSN) are investigated as biomimetic delivery vehicle for two antiretroviral compounds (ARVs), rilpivirine (RPV) and cabotegravir (CAB). Monosialodihexosylganglioside (GM3) is incorporat...
Antiviral Effects of Heparan Sulfate Analogue-Modified Two-Dimensional MXene Nanocomposites on PRRSV and SARS-CoV-2 [0.03%]
抗PRRSV和SARS-CoV-2硫酸肝素类似物修饰二维MXENE纳米复合材料的抗病毒效应
Ting Tong,Wantao Tang,Shaobo Xiao et al.
Ting Tong et al.
Due to the worldwide impact of viruses such as SARS-CoV-2, researchers have paid extensive attention to antiviral reagents against viruses. Despite extensive research on two-dimensional (2D) transition metal carbides (MXenes) in the field o...
Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds [0.03%]
甲基丙烯酸酯修饰的金纳米颗粒能够实现光交联水凝胶支架的非侵入式监测
Lan Li,Carmen J Gil,Tyler A Finamore et al.
Lan Li et al.
Photocrosslinked hydrogels, such as methacrylate-modified gelatin (gelMA) and hyaluronic acid (HAMA), are widely utilized as tissue engineering scaffolds and/or drug delivery vehicles, but lack a suitable means for non-invasive, longitudina...
Microscale concert hall acoustics to produce uniform ultrasound stimulation for targeted sonogenetics in hsTRPA1-transfected cells [0.03%]
微尺度音乐厅声学均匀产生超声波刺激以用于hsTRPA1转基因细胞的靶向声控遗传学研究
Aditya Vasan,Florian Allein,Marc Duque et al.
Aditya Vasan et al.
The field of ultrasound neuromodulation has rapidly developed over the past decade, a consequence of the discovery of strain-sensitive structures in the membrane and organelles of cells extending into the brain, heart, and other organs. Not...
CD36-Binding Amphiphilic Nanoparticles for Attenuation of Alpha Synuclein-Induced Microglial Activation [0.03%]
具有CD36结合位点的两亲性纳米颗粒用于减轻α-突触核蛋白诱导的小胶质细胞活化
Nanxia Zhao,Nicola L Francis,Shuang Song et al.
Nanxia Zhao et al.
Neuroinflammation is one of the hallmarks contributing to Parkinson's Disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular alpha synuclein (aSYN) binding to the CD36 receptor. ...
Nanoparticle Internalization Promotes the Survival of Primary Macrophages [0.03%]
纳米颗粒内吞作用可促进原代巨噬细胞的存活
Bader M Jarai,Catherine A Fromen
Bader M Jarai
Macrophages, a class of tissue resident innate immune cells, are responsible for sequestering foreign objects through the process of phagocytosis, making them a promising target for immune-modulation via particulate engineering. Here, we re...
Lipid Membrane-Based Antigen Presentation to B Cells Using a Fully Synthetic Ex Vivo Germinal Center Model [0.03%]
基于脂质膜的体外生发中心模型实现抗原呈递B细胞
Liana Kramer,Hannah W Song,Kaiya Mitchell et al.
Liana Kramer et al.
High-affinity antigen-specific B cells are generated within specialized structures, germinal centers (GCs), inside lymphoid organs. In GCs, follicular dendritic cells (FDCs) present antigens on their membrane surface to cognate B cells, ind...
(Bio)manufactured Solutions for Treatment of Bone Defects with Emphasis on US-FDA Regulatory Science Perspective [0.03%]
基于美国FDA监管科学视角的骨缺损治疗用生物制造产品
Pejman Ghelich,Mehdi Kazemzadeh-Narbat,Alireza Hassani Najafabadi et al.
Pejman Ghelich et al.
Bone defects, with second highest demand for surgeries around the globe, may lead to serious health issues and negatively influence patient lives. The advances in biomedical engineering and sciences have led to the development of several cr...
Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes [0.03%]
工程在体外构建模块化的三维肝细胞培养微环境以解析生物物理和生化微环境信号对肝细胞表型的影响
Alex J Wang,Allysa Allen,Marianna Sofman et al.
Alex J Wang et al.
In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. T...
Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats [0.03%]
对抗反复出现和大流行的流感威胁的工程纳米颗粒疫苗
Chunhong Dong,Bao-Zhong Wang
Chunhong Dong
Reoccurring seasonal flu epidemics and occasional pandemics are among the most severe threats to public health. Current seasonal influenza vaccines provide limited protection against drifted circulating strains and no protection against inf...